Novel Synthetic Methodologies. Part 103. Catalyst-Free Highly Regio- and Stereoselective Ring Opening of Epoxides and Aziridines with Sodium Azide Using Poly(ethylene glycol) as an Efficient Reaction Medium.

ChemInform ◽  
2007 ◽  
Vol 38 (28) ◽  
Author(s):  
Biswanath Das ◽  
Vtukuri Saidi Reddy ◽  
Fouzia Tehseen ◽  
Maddeboina Krishnaiah
Keyword(s):  
Ethylene Glycol ◽  
Sodium Azide ◽  
Ring Opening ◽  
Reaction Medium ◽  
Poly Ethylene Glycol ◽  
Catalyst Free ◽  
Ring Opening Of Epoxides ◽  
Synthetic Methodologies ◽  
Poly Ethylene

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1438
Author(s):  
Silvio Curia ◽  
Feifei Ng ◽  
Marie-Emérentienne Cagnon ◽  
Victor Nicoulin ◽  
Adolfo Lopez-Noriega
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Gel Chromatography ◽  
Amphiphilic Copolymers ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Acting ◽  
In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.

Direct Synthesis of Deep Cavity p-Phenylcalix[4]arene in Poly(Ethylene Glycol), and its Self-Association in the Solid State

2006 ◽  
Vol 59 (4) ◽  
pp. 260 ◽  
Author(s):  
Mohamed Makha ◽  
Colin L. Raston ◽  
Alexandre N. Sobolev
Keyword(s):  
Solid State ◽  
Ethylene Glycol ◽  
Direct Synthesis ◽  
Reaction Medium ◽  
State Structure ◽  
Poly Ethylene Glycol ◽  
Solid State Structure ◽  
Deep Cavity ◽  
Self Association ◽  
Poly Ethylene

p-Phenylcalix[4]arene is formed directly from p-phenylphenol in 66% yield (50% isolated yield) using poly(ethylene glycol) as the reaction medium, with crystallization of the pure cavitand from toluene mediated by p-carborane. The solid-state structure comprises interlocking columnar arrays.

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