Direct synthesis of amphiphilic block copolymers from glycidyl methacrylate and poly(ethylene glycol) by cationic ring-opening polymerization and supramolecular self-assembly thereof

Abstract:: Polysarcosine (psar) is a non-ionic hydrophilic polypeptoid with numerous biologically relevant properties. Polysarcosine is poly (n-methylated glycine) and has been reported first by wesley and co-workers in the 1920s. Polysarcosine was first synthesized via ring-opening polymerization (rop) of sarcosine n-carboxyanhydride, using high-vacuum techniques. Overall, findings highlight the potential of poly(sarcosine) as an alternative corona-forming polymer to poly (ethylene glycol)-based analogues of (polymerization-induced self-assembly) pisa assemblies for use in various pharmaceutical and biomedical applications. Numerous studies suggested that such polypeptoids hold enormous potential for many biomedical applications, including protein delivery, colloidal stabilization, and nanomedicine.

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Synthesis of Poly(ethylene glycol)-Block-Poly(lactide) via Sequential Ring-Opening Polymerization Technique for Preparing Micellar Carriers

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.749.433 ◽

2015 ◽

Vol 749 ◽

pp. 433-436

Author(s):

Chih Kuang Chen ◽

Wen Jen Lin ◽

Guan You Chen ◽

Yu Te Lin ◽

Rong Siou Jhu ◽

...

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Chain Length ◽

Self Assembly ◽

Ring Opening ◽

Ring Opening Polymerization ◽

Poly Ethylene Glycol ◽

Anticancer Drug Delivery ◽

Material Chemistry ◽

Poly Ethylene

With the advancement of nanotechnology and material chemistry, micelles have emerged as one of the most attractive carriers for anticancer drug delivery. In this study, a newly developed polymerization technique termed as “sequential ring-opening polymerization (SROP)“ was used to synthesize poly (ethylene glycol)-block-polylactide-block-polylactide (PEG-PLA-PLAs). Utilizing the features of SROP, well-controlled chain length of two different PLA blocks by using PEG as initiator can be achieved. Two types of PEG-PLA-PLAs, PEG-PLA11-PLA11 and PEG-PLA18-PLA18, were successfully synthesized and characterized. Having amphiphilic properties, PEG-PLA-PLAs were used to form micelles through self-assembly. The effects of PLA length on the resultant micelles were thoroughly investigated.

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Synthesis and sequence-controlled self-assembly of amphiphilic triblock copolymers based on functional poly(ethylene glycol)

Polymer Chemistry ◽

10.1039/c7py01680h ◽

2017 ◽

Vol 8 (45) ◽

pp. 6964-6971 ◽

Cited By ~ 11

Author(s):

Yanxin Qi ◽

Bin Li ◽

Yupeng Wang ◽

Yubin Huang

Keyword(s):

Ethylene Glycol ◽

Self Assembly ◽

Ring Opening ◽

Glycidyl Ether ◽

Ring Opening Polymerization ◽

Poly Ethylene Glycol ◽

Amphiphilic Triblock Copolymer ◽

Allyl Glycidyl Ether ◽

Poly Ethylene ◽

Copolymer Poly

Given the increasing prosperity of multifunctional poly(ethylene glycol) (mf-PEG), an amphiphilic triblock copolymer, poly(ethylene glycol)-block-poly(ε-caprolactone)-block-poly(allyl glycidyl ether) (mPEG-PCL-PAGE), was synthesized by a combination of living ring-opening polymerization (ROP) and click chemistry.

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Comparison of poly(ethylene glycol)-based networks obtained by cationic ring opening polymerization of neutral and 1,2,3-triazolium diepoxy monomers

Polymer Chemistry ◽

10.1039/c9py01923e ◽

2020 ◽

Vol 11 (11) ◽

pp. 1894-1905

Author(s):

Antoine Jourdain ◽

Mona M. Obadia ◽

Jannick Duchet-Rumeau ◽

Julien Bernard ◽

Anatoli Serghei ◽

...

Keyword(s):

Ethylene Glycol ◽

Ring Opening ◽

Ring Opening Polymerization ◽

Diglycidyl Ether ◽

Poly Ethylene Glycol ◽

Epoxy Networks ◽

Poly Ethylene ◽

Cationic Ring Opening Polymerization

The properties of two cross-linked epoxy networks obtained by ring opening polymerization of a synthetic diepoxy 1,2,3-triazolium and a commercial poly(ethylene glycol)diglycidyl ether using benzylamine trifluoroborate as cationic initiator are compared.

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