In the present study, a rapid, simple and an efficient procedure for the Knoevenagel condensation of
various carbonyl and active methylene compounds in ethanol at a moderate temperature in the presence
of a catalytic amount of an efficient, environmentally benign and inexpensive ammonium chloride is
reported. Simple reaction procedure, economic and ecofriendly catalyst, mild reaction conditions and
good to excellent yield of the products are the characteristic features of this study. The non-extractive
workup/purification, economic and environmentally benign catalyst make this operationally
straightforward procedure affordable for large scale.
Ammonium Chloride: An Efficient and Environmentally benign Catalyst for
Knoevenagel Condensation of Carbonyl and Active Methylene Compounds