ChemInform Abstract: An Efficient Synthesis of 3,4-Dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine Derivatives Catalyzed by Zirconyl(IV) Chloride and Evaluation of Its Biological Activities.

Background:A wide variety of biological activities are exhibited by N, O and S containing heterocycles and recently, many reports appeared for the synthesis of these heterocycles. The synthesis of heterocycles with the help of metal and non-metal catalyst has become a highly rewarding and important method in organic synthesis. This review article concentrated on the synthesis of S-heterocylces in the presence of metal and non-metal catalyst. The synthesis of five-membered S-heterocycles is described here.Objective:There is a need for the development of rapid, efficient and versatile strategy for the synthesis of heterocyclic rings. Metal, non-metal and organocatalysis involving methods have gained prominence because traditional conditions have disadvantages such as long reaction times, harsh conditions and limited substrate scope.Conclusion:The metal-, non-metal-, and organocatalyst assisted organic synthesis is a highly dynamic research field. For ßthe chemoselective and efficient synthesis of heterocyclic molecules, this protocol has emerged as a powerful route. Various methodologies in the past few years have been pointed out to pursue more sustainable, efficient and environmentally benign procedures and products. Among these processes, the development of new protocols (catalysis), which avoided the use of toxic reagents, are the focus of intense research.

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An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives

Organic & Biomolecular Chemistry ◽

10.1039/c4ob00679h ◽

2014 ◽

Vol 12 (28) ◽

pp. 5192-5200 ◽

Cited By ~ 6

Author(s):

Liangfeng Fu ◽

Qi-Xian Lin ◽

Karen T. Liby ◽

Michael B. Sporn ◽

Gordon W. Gribble

Keyword(s):

Methyl Ester ◽

Oleanolic Acid ◽

Biological Activities ◽

Efficient Synthesis

An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester).

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ChemInform Abstract: An Efficient Synthesis of Benzimidazoles via a Microwave Technique and Evaluation of Their Biological Activities.

ChemInform ◽

10.1002/chin.201341139 ◽

2013 ◽

Vol 44 (41) ◽

pp. no-no

Author(s):

Bahittin Kahveci ◽

Emre Mentese ◽

Musa Oezil ◽

Serdar Uelker ◽

Murat Ertuerk

Keyword(s):

Biological Activities ◽

Efficient Synthesis ◽

Microwave Technique

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An Efficient Synthesis of Phthalimides and Their Biological Activities

Polycyclic Aromatic Compounds ◽

10.1080/10406638.2020.1809468 ◽

2020 ◽

pp. 1-8

Author(s):

H. Jelali ◽

L. Mansour ◽

E. Deniau ◽

M. Sauthier ◽

N. Hamdi

Keyword(s):

Biological Activities ◽

Efficient Synthesis

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A Facile and Efficient Synthesis of Diaryl Amines or Ethers under Microwave Irradiation at Presence of KF/Al2O3 without Solvent and Their Anti-Fungal Biological Activities against Six Phytopathogens

International Journal of Molecular Sciences ◽

10.3390/ijms140918850 ◽

2013 ◽

Vol 14 (9) ◽

pp. 18850-18860 ◽

Cited By ~ 10

Author(s):

Liang-Zhu Huang ◽

Pan Han ◽

You-Qiang Li ◽

Ying-Meng Xu ◽

Tao Zhang ◽

...

Keyword(s):

Microwave Irradiation ◽

Biological Activities ◽

Efficient Synthesis ◽

Anti Fungal ◽

Diaryl Amines

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Synthesis of novel carbohydrate mimetics via 1,2-oxazines

Pure and Applied Chemistry ◽

10.1351/pac-con-11-09-20 ◽

2011 ◽

Vol 84 (1) ◽

pp. 23-36 ◽

Cited By ~ 32

Author(s):

Léa Bouché ◽

Hans-Ulrich Reissig

Keyword(s):

Lewis Acid ◽

Good Yield ◽

Biological Activities ◽

Amino Sugar ◽

Sugar Alcohols ◽

Bicyclic Compounds ◽

Efficient Route ◽

Oxazine Derivatives

The combination of lithiated alkoxyallenes with carbohydrate-derived nitrones constitutes a flexible entry to highly functionalized enantiopure 1,2-oxazine derivatives. They can be used as precursors for acyclic and cyclic carbohydrate-like products such as amino sugar alcohols, azetidine and pyrrolidine derivatives. The Lewis acid-promoted rearrangement of 1,3-dioxolanyl-substituted 1,2-oxazines to bicyclic compounds allows an efficient route to novel amino pyran and oxepane derivatives. After subsequent transformations, new carbohydrate mimetics or “real” carbohydrates were obtained in good yield and often in a stereodivergent fashion. These compounds have already been employed for the preparation of unusual di- and trisaccharide derivatives. Several of the products prepared showed interesting biological activities, e.g., as L- and P-selectin inhibitors with IC50 values in the subnanomolar range.

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