An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives

2014 ◽  
Vol 12 (28) ◽  
pp. 5192-5200 ◽  
Author(s):  
Liangfeng Fu ◽  
Qi-Xian Lin ◽  
Karen T. Liby ◽  
Michael B. Sporn ◽  
Gordon W. Gribble
Keyword(s):  
Methyl Ester ◽  
Oleanolic Acid ◽  
Biological Activities ◽  
Efficient Synthesis

An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester).

Metal and Non-Metal Catalysts in the Synthesis of Five-Membered S-Heterocycles

2019 ◽  
Vol 16 (2) ◽  
pp. 258-275 ◽  
Author(s):  
Navjeet Kaur
Keyword(s):  
Organic Synthesis ◽  
Biological Activities ◽  
Reaction Times ◽  
Research Field ◽  
Environmentally Benign ◽  
Metal Catalyst ◽  
Efficient Synthesis ◽  
Heterocyclic Molecules ◽  
The Past ◽  
Harsh Conditions

Background:A wide variety of biological activities are exhibited by N, O and S containing heterocycles and recently, many reports appeared for the synthesis of these heterocycles. The synthesis of heterocycles with the help of metal and non-metal catalyst has become a highly rewarding and important method in organic synthesis. This review article concentrated on the synthesis of S-heterocylces in the presence of metal and non-metal catalyst. The synthesis of five-membered S-heterocycles is described here.Objective:There is a need for the development of rapid, efficient and versatile strategy for the synthesis of heterocyclic rings. Metal, non-metal and organocatalysis involving methods have gained prominence because traditional conditions have disadvantages such as long reaction times, harsh conditions and limited substrate scope.Conclusion:The metal-, non-metal-, and organocatalyst assisted organic synthesis is a highly dynamic research field. For ßthe chemoselective and efficient synthesis of heterocyclic molecules, this protocol has emerged as a powerful route. Various methodologies in the past few years have been pointed out to pursue more sustainable, efficient and environmentally benign procedures and products. Among these processes, the development of new protocols (catalysis), which avoided the use of toxic reagents, are the focus of intense research.

ChemInform Abstract: An Efficient Synthesis of Benzimidazoles via a Microwave Technique and Evaluation of Their Biological Activities.

ChemInform ◽  
2013 ◽  
Vol 44 (41) ◽  
pp. no-no
Author(s):  
Bahittin Kahveci ◽  
Emre Mentese ◽  
Musa Oezil ◽  
Serdar Uelker ◽  
Murat Ertuerk
Keyword(s):  
Biological Activities ◽  
Efficient Synthesis ◽  
Microwave Technique

scholarly journals Synthesis and antitumor activity of fluorouracil – oleanolic acid/ursolic acid/glycyrrhetinic acid conjugates

MedChemComm ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 1370-1378 ◽  
Author(s):  
Chun-Mei Liu ◽  
Jia-Yan Huang ◽  
Li-Xin Sheng ◽  
Xiao-An Wen ◽  
Ke-Guang Cheng
Keyword(s):  
Antitumor Activity ◽  
Adverse Effects ◽  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Biological Activities ◽  
Glycyrrhetinic Acid ◽  
Antitumor Activities ◽  
Pentacyclic Triterpene ◽  
Pentacyclic Triterpenes

Due to the obvious adverse effects of 5-fluorouracil and considering the diverse biological activities of pentacyclic triterpenes, twelve pentacyclic triterpene-5-fluorouracil conjugates were synthesized and their antitumor activities were evaluated.

An Efficient Synthesis of Phthalimides and Their Biological Activities

2020 ◽  
pp. 1-8
Author(s):  
H. Jelali ◽  
L. Mansour ◽  
E. Deniau ◽  
M. Sauthier ◽  
N. Hamdi
Keyword(s):  
Biological Activities ◽  
Efficient Synthesis

ChemInform Abstract: Oleanolic Acid Synthetic Oligoglycosides: A Review on Recent Progress in Biological Activities

ChemInform ◽  
2014 ◽  
Vol 45 (39) ◽  
pp. no-no ◽  
Author(s):  
Kuo Xu ◽  
Fuhao Chu ◽  
Guoliang Li ◽  
Xin Xu ◽  
Penglong Wang ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Recent Progress ◽  
Biological Activities

scholarly journals Efficient Synthesis and Anti-Fungal Activity of Oleanolic Acid Oxime Esters

Molecules ◽  
2013 ◽  
Vol 18 (3) ◽  
pp. 3615-3629 ◽  
Author(s):  
Hanqing Zhao ◽  
Minjie Zhou ◽  
Lifeng Duan ◽  
Wei Wang ◽  
Jianjun Zhang ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Efficient Synthesis ◽  
Fungal Activity ◽  
Anti Fungal
Sign in / Sign up

Export Citation Format

Share Document