ChemInform Abstract: One-Pot Multicomponent Condensation Reaction of Aldehydes with Cyclic Ketones.

ChemInform ◽  
2011 ◽  
Vol 42 (32) ◽  
pp. no-no
Author(s):  
Ping Wu ◽  
Xi-Mei Cai ◽  
Qi-Fang Wang ◽  
Chao-Guo Yan
Keyword(s):  
Condensation Reaction ◽  
Cyclic Ketones ◽  
One Pot ◽  
Multicomponent Condensation

One-Pot Multicomponent Condensation Reaction of Aldehydes with Cyclic Ketones

2011 ◽  
Vol 41 (6) ◽  
pp. 841-850 ◽  
Author(s):  
Ping Wu ◽  
Xi-Mei Cai ◽  
Qi-Fang Wang ◽  
Chao-Guo Yan
Keyword(s):  
Condensation Reaction ◽  
Cyclic Ketones ◽  
One Pot ◽  
Multicomponent Condensation

scholarly journals Solvent-free preparation of amidoalkyl phenols catalyzed by trityl chloride under neutral media

2015 ◽  
Vol 93 (11) ◽  
pp. 1245-1248 ◽  
Author(s):  
Ahmad Reza Moosavi-Zare ◽  
Mohammad Ali Zolfigol ◽  
Fateme Derakhshan-Panah ◽  
Masoume Daraei
Keyword(s):  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Solvent Free ◽  
One Pot ◽  
Multicomponent Condensation ◽  
Solvent Free Condition ◽  
Neutral Media ◽  
In Situ Generation

A one-pot, multicomponent condensation reaction of phenols, aromatic aldehydes, and amides in the presence of catalytic amount of trityl chloride as a homogeneous organocatalyst under solvent-free condition to prepare amidoalkyl phenols has been reported. It is interesting that trityl chloride by in situ generation of trityl carbocation with inherent instability catalyzes the reaction.

scholarly journals Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and Evaluation of Cytotoxic Effects

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Harshita Sachdeva ◽  
Rekha Saroj ◽  
Sarita Khaturia ◽  
Diksha Dwivedi ◽  
Om Prakash Chauhan
Keyword(s):  
Schiff Bases ◽  
Micrococcus Luteus ◽  
Condensation Reaction ◽  
Cancer Cell Line ◽  
Lemon Juice ◽  
Alternaria Brassicicola ◽  
Human Colon Cancer ◽  
One Pot ◽  
Cytotoxic Effects ◽  
Multicomponent Condensation

Green chemical one-pot multicomponent condensation reaction of substituted 1H-indole-2,3-diones (1), various amino acids (2), and thiosemicarbazide (3) is found to be catalyzed by lemon juice as natural acid using water as a green solvent to give the corresponding Schiff bases (4) in good to excellent yields. This method is experimentally simple, clean, high yielding, and green, with reduced reaction times. The product is purified by simple filtration followed by washing with water and drying process. The synthesized compounds are characterized by FT-IR,13CNMR, and1HNMR spectroscopy and are screened for their antifungal activity againstAspergillus niger,Penicillium notatum,Fusarium oxysporum,Alternaria brassicicola,Chaetomium orium, andLycopodium sp.and antibacterial activity against Gram-positive bacteria,Bacillus licheniformis,Staphylococcus aureus, andMicrococcus luteus,and Gram-negative bacteria,Pseudomonas aeruginosaandEscherichia coli. Compounds have also been evaluated for cytotoxic effects against human colon cancer cell line Colo205.

Heterogeneous recyclable nano-CeO2 catalyst: efficient and eco-friendly synthesis of novel fused triazolo and tetrazolo pyrimidine derivatives in aqueous medium

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 68788-68797 ◽  
Author(s):  
Lingala Suresh ◽  
P. Sagar Vijay Kumar ◽  
T. Vinodkumar ◽  
G. V. P. Chandramouli
Keyword(s):  
Aqueous Medium ◽  
Condensation Reaction ◽  
Bond Formation ◽  
Aromatic Aldehydes ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Multicomponent Condensation ◽  
The One

A ceria nanocatalyst was used for the one-pot, multicomponent condensation reaction of benzoylacetonitrile, aromatic aldehydes and 5-amino-triazole/tetrazole proceeding via C–C and C–N bond formation to deliver triazolo/tetrazolo[1,5-a]pyrimidines.

scholarly journals Design, synthesis and cytotoxic evaluation of 2-amino-4- aryl-6-substituted pyridine-3,5-dicarbonitrile derivatives

2021 ◽  
Vol 20 (10) ◽  
pp. 2127-2133
Author(s):  
Amr S. Abu Lila ◽  
Marwa H. Abdallah ◽  
El-Sayed Khafagy ◽  
Tamer M. Shehata ◽  
Mahmoud S. Soliman ◽  
...  
Keyword(s):  
Cell Lines ◽  
Condensation Reaction ◽  
In Vitro Cytotoxicity ◽  
In Vivo Studies ◽  
Primary Amines ◽  
Binding Modes ◽  
One Pot ◽  
Multicomponent Condensation

Purpose: To synthesize novel pyridine derivatives and evaluate their efficiency as potent inhibitors of cyclin dependent kinase 2 (CDK2) enzyme for cancer therapy.Methods: Pyridine scaffold were synthesized using one-pot multicomponent condensation reaction of arylidine with different primary amines. The cytotoxic potential of the new compounds was assessed using various cell lines. Furthermore, molecular docking studies based on the crystal structure of CDK2 was carried out to determine the possible binding modes that influence the anticancer activities.Results: The results indicate that one-pot multicomponent reaction generated a series of functionalized pyridines with good yield. In vitro cytotoxicity study revealed superior cytotoxicity of the designed compounds against prostate and cervical cancer cell lines compared to 5-fluorouracil (standard anticancer compound) with half-maximal inhibitory concentration (IC50) values of 0.1 – 0.85 and 1.2 –74.1 μM, respectively. Finally, molecular modeling simulation of the newly synthesized compounds showed that they fit well and are stabilized into CDK2 active site via hydrogen bonding and hydrophobic interactions.Conclusion: The results indicate that the newly synthesized pyridine can exert potent anticancer activity presumably via inhibition of CDK2. However, this will need to be confirmed in in vivo studies.

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