ChemInform Abstract: Discovery of BI 99179, a Potent and Selective Inhibitor of Type I Fatty Acid Synthase with Central Exposure.

ChemInform ◽  
2012 ◽  
Vol 43 (8) ◽  
pp. no-no
Author(s):  
Joerg T. Kley ◽  
Juergen Mack ◽  
Bradford Hamilton ◽  
Stefan Scheuerer ◽  
Norbert Redemann
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Selective Inhibitor ◽  
Type I

scholarly journals Production of long chain alcohols and alkanes upon coexpression of an acyl-ACP reductase and aldehyde-deformylating oxygenase with a bacterial type-I fatty acid synthase in E. coli

2015 ◽  
Vol 11 (9) ◽  
pp. 2464-2472 ◽  
Author(s):  
Dan Coursolle ◽  
Jiazhang Lian ◽  
John Shanklin ◽  
Huimin Zhao
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Type I ◽  
E Coli ◽  
Bacterial Type ◽  
Long Chain

An orthogonal type I FAS was introduced into E. coli to increase the production of long chain alcohols and alkanes.

3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors

2006 ◽  
Vol 16 (17) ◽  
pp. 4620-4623 ◽  
Author(s):  
Alexey Rivkin ◽  
Yoona R. Kim ◽  
Mark T. Goulet ◽  
Nathan Bays ◽  
Armetta D. Hill ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Type I

scholarly journals Type I fatty acid synthase trapped in the octanoyl‐bound state

2020 ◽  
Vol 29 (2) ◽  
pp. 589-605 ◽  
Author(s):  
Alexander Rittner ◽  
Karthik S. Paithankar ◽  
Aaron Himmler ◽  
Martin Grininger
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Bound State ◽  
Type I

Structural Similarities between 6-Methylsalicylic Acid Synthase fromPenicillium patulumand Vertebrate Type I Fatty Acid Synthase:  Evidence from Thiol Modification Studies†

Biochemistry ◽  
1996 ◽  
Vol 35 (38) ◽  
pp. 12267-12274 ◽  
Author(s):  
Christopher J. Child ◽  
Jonathan B. Spencer ◽  
Pamela Bhogal ◽  
Peter M. Shoolingin-Jordan
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Type I ◽  
Methylsalicylic Acid Synthase

Molecular analysis of a Type I fatty acid synthase in Cryptosporidium parvum

2000 ◽  
Vol 105 (2) ◽  
pp. 253-260 ◽  
Author(s):  
Guan Zhu ◽  
Mary J Marchewka ◽  
Keith M Woods ◽  
Steve J Upton ◽  
Janet S Keithly
Keyword(s):  
Fatty Acid ◽  
Molecular Analysis ◽  
Cryptosporidium Parvum ◽  
Fatty Acid Synthase ◽  
Type I

scholarly journals A Mammalian Type I Fatty Acid Synthase Acyl Carrier Protein Domain Does Not Sequester Acyl Chains

2007 ◽  
Vol 283 (1) ◽  
pp. 518-528 ◽  
Author(s):  
Eliza Ploskoń ◽  
Christopher J. Arthur ◽  
Simon E. Evans ◽  
Christopher Williams ◽  
John Crosby ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Acyl Carrier Protein ◽  
Protein Domain ◽  
Carrier Protein ◽  
Type I ◽  
Acyl Chains
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