Ultrasensitive Detection and Binding Mechanism of Cocaine in an Aptamer‐based Single‐molecule Device

2019 ◽  
Vol 37 (9) ◽  
pp. 897-902 ◽  
Author(s):  
Xinjiani Chen ◽  
Chenguang Zhou ◽  
Xuefeng Guo
Keyword(s):  
Single Molecule ◽  
Ultrasensitive Detection ◽  
Binding Mechanism

Single-molecule FRET for Ultrasensitive Detection of Biomolecules

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Kun Yang ◽  
Yong Yang ◽  
Chun-yang Zhang
Keyword(s):  
Single Molecule ◽  
New Technologies ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Molecular Probes ◽  
Ultrasensitive Detection ◽  
Single Molecule Fret ◽  
Biological Reaction ◽  
Spatio Temporal ◽  
Detection Of Biomolecules

AbstractSingle-molecule Förster resonance energy transfer (sm- FRET) has been widely employed to detect biomarkers and to probe the structure and dynamics of biomolecules. By monitoring the biological reaction in a spatio-temporal manner, smFRET can reveal the transient intermediates of biological processes that cannot be obtained by conventional ensemble measurements. This review provides an overview of singlemolecule FRET and its applications in ultrasensitive detection of biomolecules, including the major techniques and the molecular probes used for smFRET as well as the biomedical applications of smFRET. Especially, the combination of sm- FRET with new technologies might expand its applications in clinical diagnosis and biomedical research

scholarly journals Ultrasensitive Detection of Attomolar Protein Concentrations by Dropcast Single Molecule Assays

2020 ◽  
Vol 142 (28) ◽  
pp. 12314-12323 ◽  
Author(s):  
Connie Wu ◽  
Padric M. Garden ◽  
David R. Walt
Keyword(s):  
Single Molecule ◽  
Ultrasensitive Detection

scholarly journals Ultrasensitive Detection of Enzymatic Activity Using Single Molecule Arrays

2020 ◽  
Vol 142 (35) ◽  
pp. 15098-15106
Author(s):  
Xu Wang ◽  
Alana F. Ogata ◽  
David R. Walt
Keyword(s):  
Enzymatic Activity ◽  
Single Molecule ◽  
Ultrasensitive Detection

Single-molecule atomic force microscopy unravels the binding mechanism of aBurkholderia cenocepaciatrimeric autotransporter adhesin

2013 ◽  
Vol 89 (4) ◽  
pp. 649-659 ◽  
Author(s):  
Sofiane El-Kirat-Chatel ◽  
Dalila Mil-Homens ◽  
Audrey Beaussart ◽  
Arsenio M. Fialho ◽  
Yves F. Dufrêne
Keyword(s):  
Atomic Force Microscopy ◽  
Single Molecule ◽  
Binding Mechanism ◽  
Force Microscopy ◽  
Atomic Force

scholarly journals Simultaneous and ultrasensitive detection of multiple microRNAs by single-molecule fluorescence imaging

2020 ◽  
Vol 11 (15) ◽  
pp. 3812-3819 ◽  
Author(s):  
Hongding Zhang ◽  
Xuedong Huang ◽  
Jianwei Liu ◽  
Baohong Liu
Keyword(s):  
Fluorescence Imaging ◽  
Single Molecule ◽  
Ultrasensitive Detection ◽  
Single Molecule Fluorescence ◽  
Microrna Detection

A single-molecule assay for multiple microRNA detection.

pH-Activated Single Molecule Conductance and Binding Mechanism of Imidazole on Gold

Nano Letters ◽  
2020 ◽  
Vol 20 (6) ◽  
pp. 4687-4692 ◽  
Author(s):  
Xiaoyun Pan ◽  
Brent Lawson ◽  
Andrea M. Rustad ◽  
Maria Kamenetska
Keyword(s):  
Single Molecule ◽  
Binding Mechanism

A single molecule assay for ultrasensitive detection of Fn14 in human serum

2019 ◽  
Vol 587 ◽  
pp. 113467 ◽  
Author(s):  
Yichen Chen ◽  
Qiyong Cai ◽  
Song Liu
Keyword(s):  
Human Serum ◽  
Single Molecule ◽  
Ultrasensitive Detection
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