scholarly journals Isometric handgrip exercise during dobutamine-atropine stress echocardiography increases heart rate acceleration and decreases study duration and dobutamine and atropine dosage

2003 ◽  
Vol 26 (5) ◽  
pp. 238-242 ◽  
Author(s):  
Siu-Sun Yao ◽  
Sonja Moldenhauer ◽  
Mark V. Sherrid
Keyword(s):  
Heart Rate ◽  
Stress Echocardiography ◽  
Handgrip Exercise ◽  
Heart Rate Acceleration ◽  
Isometric Handgrip ◽  
Study Duration ◽  
Rate Acceleration ◽  
Isometric Handgrip Exercise

Chemoreflex and metaboreflex control during static hypoxic exercise

2005 ◽  
Vol 288 (4) ◽  
pp. H1724-H1729 ◽  
Author(s):  
Anne Houssiere ◽  
Boutaina Najem ◽  
Agniezka Ciarka ◽  
Sonia Velez-Roa ◽  
Robert Naeije ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Circulatory Arrest ◽  
Handgrip Exercise ◽  
Isometric Handgrip ◽  
Isometric Handgrip Exercise ◽  
Baseline Values ◽  
Hypoxic Exercise

To investigate the effects of muscle metaboreceptor activation during hypoxic static exercise, we recorded muscle sympathetic nerve activity (MSNA), heart rate, blood pressure, ventilation, and blood lactate in 13 healthy subjects (22 ± 2 yr) during 3 min of three randomized interventions: isocapnic hypoxia (10% O2) (chemoreflex activation), isometric handgrip exercise in normoxia (metaboreflex activation), and isometric handgrip exercise during isocapnic hypoxia (concomitant metaboreflex and chemoreflex activation). Each intervention was followed by a forearm circulatory arrest to allow persistent metaboreflex activation in the absence of exercise and chemoreflex activation. Handgrip increased blood pressure, MSNA, heart rate, ventilation, and lactate (all P < 0.001). Hypoxia without handgrip increased MSNA, heart rate, and ventilation (all P < 0.001), but it did not change blood pressure and lactate. Handgrip enhanced blood pressure, heart rate, MSNA, and ventilation responses to hypoxia (all P < 0.05). During circulatory arrest after handgrip in hypoxia, heart rate returned promptly to baseline values, whereas ventilation decreased but remained elevated ( P < 0.05). In contrast, MSNA, blood pressure, and lactate returned to baseline values during circulatory arrest after hypoxia without exercise but remained markedly increased after handgrip in hypoxia ( P < 0.05). We conclude that metaboreceptors and chemoreceptors exert differential effects on the cardiorespiratory and sympathetic responses during exercise in hypoxia.

scholarly journals Effect of age on the hemodynamic and sympathetic responses at the onset of isometric handgrip exercise

2014 ◽  
Vol 116 (2) ◽  
pp. 222-227 ◽  
Author(s):  
Sophie Lalande ◽  
Carolyn P. Sawicki ◽  
Jacquie R. Baker ◽  
J.Kevin Shoemaker
Keyword(s):  
Heart Rate ◽  
Total Peripheral Resistance ◽  
Pressor Response ◽  
Muscle Sympathetic Nerve Activity ◽  
Peripheral Resistance ◽  
Older Individuals ◽  
Handgrip Exercise ◽  
Isometric Handgrip ◽  
Vasoconstrictor Response ◽  
Isometric Handgrip Exercise

Cardiac and peripheral vasomotor factors contribute to the rapid pressor response at the onset of isometric handgrip exercise. We tested the hypothesis that age enhances the sympathetic and vasoconstrictor response at the onset of isometric handgrip exercise so that the pressor response is maintained, despite a diminished cardiac function. Twelve young and twelve older (24 ± 3 and 63 ± 8 yr) individuals performed 20-s isometric handgrip exercise at 30, 40, or 50% of maximal voluntary contraction force. Muscle sympathetic nerve activity (MSNA) was measured using microneurography. Mean arterial pressure (MAP) and cardiac output (Q̇) were assessed continuously by finger plethysmography and total peripheral resistance was calculated. MAP increased with the onset of handgrip; this increase was associated with handgrip intensity and was similar in both groups. Heart rate and Q̇ increased with increasing handgrip intensity in both groups, but increases were greater in young vs. older individuals (age × handgrip intensity interaction, P < 0.05). MSNA burst frequency increased ( P < 0.01), while MSNA burst incidence tended to increase ( P = 0.06) with increasing handgrip intensity in both groups. The change in MSNA between baseline and handgrip, for both frequency and incidence, increased with increasing handgrip intensity for both groups. There was no effect of handgrip intensity or age on total peripheral resistance. The smaller heart rate and Q̇ response during the first 20 s of handgrip exercise in older individuals was not accompanied by a greater sympathetic activation or vasoconstrictor response. However, increases in MAP were similar between groups, indicating that the pressor response at the onset of handgrip exercise is preserved with aging.

Effects of Chronic Atenolol Therapy on Cardiovascular Response to Isometric Exercise in Essential Hypertension

1989 ◽  
Vol 17 (2) ◽  
pp. 125-131
Author(s):  
Y. Kobayashi ◽  
K. Kuniyoshi ◽  
H. Miyata ◽  
S. Kawata ◽  
N. Kajiwara
Keyword(s):  
Heart Rate ◽  
Cardiovascular Response ◽  
Isometric Exercise ◽  
Peripheral Resistance ◽  
Posterior Wall ◽  
Triple Product ◽  
Handgrip Exercise ◽  
Isometric Handgrip ◽  
Mean Velocity ◽  
Isometric Handgrip Exercise

Cardiovascular response to 2 min of isometric handgrip exercise at 50% of maximum voluntary contraction was studied echocardiographically in 10 essential hypertensives, before and during treatment with atenolol for a mean of 2 months. The patients responded with increases in heart rate, systolic and diastolic blood pressures, cardiac output and calculated triple product, no changes in stroke volume and total peripheral resistance, and decreases in ejection fraction, mean velocity of circumferential shortening and mean diastolic posterior wall velocity of the left ventricle before treatment. Chronic atenolol therapy attenuated the increases in heart rate, blood pressure and triple product, and the decreases in ejection fraction, mean velocity of circumferential shortening and mean diastolic posterior wall velocity of the left ventricle but resulted in a marked increase in total peripheral resistance. The pressure response and triple product rise in response to isometric handgrip exercise were also decreased. This suggests an obvious advantage to hypertensive patients who may, therefore, be protected from the risk of cardiovascular complications following isometric exercise.

Sympathetic neural reactivity to stress does not increase with age in healthy humans

1994 ◽  
Vol 267 (1) ◽  
pp. H344-H353 ◽  
Author(s):  
A. V. Ng ◽  
R. Callister ◽  
D. G. Johnson ◽  
D. R. Seals
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Arterial Pressure ◽  
Cold Pressor Test ◽  
Cold Pressor ◽  
Handgrip Exercise ◽  
Isometric Handgrip ◽  
Isometric Handgrip Exercise ◽  
Sympathetic Nervous ◽  
Older Subjects

Sympathetic nervous system reactivity to stress is though to increase with age in humans. We tested this hypothesis by recording postganglionic sympathetic nerve activity to skeletal muscle (MSNA) (peroneal microneurography) and by measuring plasma norepinephrine concentrations (PNE), heart rate, and arterial pressure before (prestress control) and during cognitive challenge (mental arithmetic and colored word test), thermal stress (i.e., the cold pressor test), and exhaustive isometric handgrip exercise (40% of maximum voluntary force)/postexercise ischemia in 15 older (60-74 yr, mean +/- SE = 64 +/- 1) and 15 young (19–30 yr, mean +/- SE = 25 +/- 1) healthy men and women (8 males, 7 females each). The initial prestress control level of MSNA was higher in the older subjects (P < 0.01 vs. young), but there were no significant differences for PNE, heart rate, or arterial pressure. The MSNA and PNE responses to mental stress were small and not different in the two groups. MSNA and PNE increased markedly in response to the cold pressor test and isometric handgrip exercise/post exercise ischemia in both groups. The absolute unit increases in MSNA were similar in the two groups, but the relative (percentage) increases were actually smaller in the older subjects (P < 0.05 vs. young) due to their elevated baseline levels. The stress-evoked increases in arterial pressure were similar in the groups, but the older subjects tended to demonstrate smaller increases in heart rate. In general, no gender differences were noted in either age group. These findings fail to support the long-held concept that stress-induced sympathetic nervous system stimulation becomes exaggerated with age. Thus, sympathetic neural hyperreactivity does not appear to be a fundamental property of the aging process in humans.

scholarly journals Impact of age, sex and heart rate variability on the acute cardiovascular response to isometric handgrip exercise

2020 ◽  
Author(s):  
Nicholas Cauwenberghs ◽  
Véronique Cornelissen ◽  
Jeffrey W. Christle ◽  
Kristofer Hedman ◽  
Jonathan Myers ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cardiovascular Response ◽  
Handgrip Exercise ◽  
Isometric Handgrip ◽  
Isometric Handgrip Exercise
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