Applications and Limitations of Noninvasive Methods for Evaluating Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of elevated liver function tests results, after the commonly investigated causes have been excluded, and frequently coexists with type 2 diabetes mellitus (T2DM) because the conditions have common risk factors. As both T2DM and NAFLD are related to adverse outcomes of the other, diagnosis and valuation of fatty liver is an important part of the management of diabetes. Although noninvasive methods, such as biomarkers, panel markers, and imaging, may support a diagnostic evaluation of NAFLD patients, accurate histopathological findings cannot be achieved without a liver biopsy. As it is important to know whether steatohepatitis and liver fibrosis are present for the management of NAFLD, liver biopsy remains the gold standard for NAFLD diagnosis and evaluation. Therefore, new investigations of the pathogenesis of NAFLD are necessary to develop useful biomarkers that could provide a reliable noninvasive alternative to liver biopsy.

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Su1553 – Oral and Gut Microbiome Diversity in Patients with Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Fibrosis

Gastroenterology ◽

10.1016/s0016-5085(19)40247-3 ◽

2019 ◽

Vol 156 (6) ◽

pp. S-1295-S-1296

Author(s):

Rohini Mehta ◽

James Paik ◽

Sean C. Felix ◽

Hussain Allawi ◽

Ingrid Schneider ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Hepatic Fibrosis ◽

Gut Microbiome ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver ◽

Microbiome Diversity

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Dietary patterns in relation to hepatic fibrosis among patients with nonalcoholic fatty liver disease

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s198744 ◽

2019 ◽

Vol Volume 12 ◽

pp. 315-324 ◽

Cited By ~ 11

Author(s):

Davood Soleimani ◽

Golnaz Ranjbar ◽

Reza Rezvani ◽

Ladan Goshayeshi ◽

Farkhonde Razmpour ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Hepatic Fibrosis ◽

Dietary Patterns ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver

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Glycemic Variability Is an Independent Predictive Factor for Development of Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease

PLoS ONE ◽

10.1371/journal.pone.0076161 ◽

2013 ◽

Vol 8 (11) ◽

pp. e76161 ◽

Cited By ~ 27

Author(s):

Motoi Hashiba ◽

Masafumi Ono ◽

Hideyuki Hyogo ◽

Yukio Ikeda ◽

Kosei Masuda ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Hepatic Fibrosis ◽

Predictive Factor ◽

Fatty Liver Disease ◽

Glycemic Variability ◽

Independent Predictive Factor ◽

Nonalcoholic Fatty Liver

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The Role of Long Non-Coding RNAs (lncRNAs) in the Development and Progression of Fibrosis Associated with Nonalcoholic Fatty Liver Disease (NAFLD)

Non-Coding RNA ◽

10.3390/ncrna4030018 ◽

2018 ◽

Vol 4 (3) ◽

pp. 18 ◽

Cited By ~ 5

Author(s):

Amanda Hanson ◽

Danielle Wilhelmsen ◽

Johanna DiStefano

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Molecular Mechanisms ◽

Disease Diagnosis ◽

Noninvasive Methods ◽

Nonalcoholic Fatty Liver ◽

Potential Applicability ◽

Non Coding Rnas

Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of conditions ranging from hepatic steatosis to inflammation (nonalcoholic steatohepatitis or NASH) with or without fibrosis, in the absence of significant alcohol consumption. The presence of fibrosis in NASH patients is associated with greater liver-related morbidity and mortality; however, the molecular mechanisms underlying the development of fibrosis and cirrhosis in NAFLD patients remain poorly understood. Long non-coding RNAs (lncRNAs) are emerging as key contributors to biological processes that are underpinning the initiation and progression of NAFLD fibrosis. This review summarizes the experimental findings that have been obtained to date in animal models of liver fibrosis and NAFLD patients with fibrosis. We also discuss the potential applicability of circulating lncRNAs to serve as biomarkers for the diagnosis and prognosis of NAFLD fibrosis. A better understanding of the role played by lncRNAs in NAFLD fibrosis is critical for the identification of novel therapeutic targets for drug development and improved, noninvasive methods for disease diagnosis.

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