scholarly journals Chemical and Structural Strategies to Selectively Target mTOR Kinase

ChemMedChem ◽  
2021 ◽  
Author(s):  
Chiara Borsari ◽  
Martina De Pascale ◽  
Matthias P. Wymann
Keyword(s):  
Mtor Kinase

mTOR kinase activity disrupts a phosphorylation signaling network in schizophrenia brain

2021 ◽  
Author(s):  
Radhika Chadha ◽  
Khaled Alganem ◽  
Robert E. Mccullumsmith ◽  
James H. Meador-Woodruff
Keyword(s):  
Kinase Activity ◽  
Signaling Network ◽  
Mtor Kinase

scholarly journals mTOR kinase inhibitors as potential cancer therapeutic drugs

2013 ◽  
Vol 340 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Shi-Yong Sun
Keyword(s):  
Kinase Inhibitors ◽  
Mtor Kinase ◽  
Therapeutic Drugs ◽  
Potential Cancer

Generation and Characterization of Monoclonal Antibodies to mTOR Kinase

Hybridoma ◽  
2008 ◽  
Vol 27 (5) ◽  
pp. 395-399 ◽  
Author(s):  
Ivan Nemazanyy ◽  
Oksana Breus ◽  
Ivan Gout ◽  
Valeriy Filonenko ◽  
Ganna Panasyuk
Keyword(s):  
Monoclonal Antibodies ◽  
Mtor Kinase

scholarly journals Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasis

2018 ◽  
Vol 10 (1) ◽  
pp. 35-53 ◽  
Author(s):  
Qing Zhang ◽  
Agnès Duplany ◽  
Vincent Moncollin ◽  
Sandrine Mouradian ◽  
Evelyne Goillot ◽  
...  
Keyword(s):  
Early Onset ◽  
Kinase Activity ◽  
Whole Body ◽  
Mtor Kinase

scholarly journals HIF-mediated Suppression of DEPTOR Confers Resistance to mTOR Kinase Inhibition in Renal Cancer

iScience ◽  
2019 ◽  
Vol 21 ◽  
pp. 509-520 ◽  
Author(s):  
Hong Doan ◽  
Alexander Parsons ◽  
Shruthi Devkumar ◽  
Jogitha Selvarajah ◽  
Francesc Miralles ◽  
...  
Keyword(s):  
Renal Cancer ◽  
Kinase Inhibition ◽  
Mtor Kinase

mTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations

2012 ◽  
Vol 326 (2) ◽  
pp. 168-175 ◽  
Author(s):  
Ulka Vijapurkar ◽  
Liliane Robillard ◽  
Siqun Zhou ◽  
Michael Degtyarev ◽  
Kui Lin ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Mek Inhibitors ◽  
Mtor Kinase

Morphological Observation of the Cashmere Goat Fetal Fibroblasts after mTOR Kinase Inhibition with Combination of Fluorescent Dyes and Confocal Cell Imaging

2011 ◽  
Vol 343-344 ◽  
pp. 590-593
Author(s):  
Yan Liang ◽  
Xiao Jing Wang ◽  
Shu Yu Li ◽  
Cheberi ◽  
Zhi Gang Wang ◽  
...  
Keyword(s):  
Inner Mongolia ◽  
Mammalian Cells ◽  
Fluorescent Dyes ◽  
Cell Structure ◽  
Critical Role ◽  
Laser Scanning Microscopy ◽  
Morphological Observation ◽  
Cashmere Goat ◽  
Mtor Kinase ◽  
Fetal Fibroblasts

The mammalian target of rapamycin（mTOR）is a kind of Ser/Thr kinase in mammalian cells. It can recruit and integrate input signals from nutrients, growth factors, energy and environmental stress to regulate cell growth and proliferation via different cellular processes. This study uses the fetal fibroblasts of Inner Mongolia Cashmere goat (Capra hircas) to prove that the mTOR plays a critical role in formation of the cell cytoskeleton structure. The mTOR kinase activity was inhibited in Inner Mongolia Cashmere goat fetal fibroblasts (GFb) after treatment with CCI-779 (temsirolimus), an mTOR specific inhibitor for 48 h. The results showed that GFb cells were sensitive to CCI-779. GFb cells morphology and its cytoskeleton structure changed under confocal laser scanning microscopy stained with the Fluorescent phalloidin (50µg/ml, Phalloidin-FITC5282) which combines with F-actin. In summary, mTOR signaling pathway was proved to be functional in GFb cells and acts as a key regulator to form cell structure. The Morphological results indicated that perhaps the synthesis of microfilament or organization of cytoskeleton was disrupted in GFb cells when mTOR was inhibited.

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