Drug‐derived surface‐active ionic liquids: a cost‐effective way to expressively increase blood‐stage antimalarial activity of primaquine

ChemMedChem ◽  
2021 ◽  
Author(s):  
Ana Teresa Silva ◽  
Isabel S. Oliveira ◽  
Joana Gomes ◽  
Luísa Aguiar ◽  
Diana Fontinha ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Antimalarial Activity ◽  
Cost Effective ◽  
Blood Stage ◽  
Surface Active

scholarly journals Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine

2020 ◽  
Vol 21 (15) ◽  
pp. 5334 ◽  
Author(s):  
Ana Teresa Silva ◽  
Lis Lobo ◽  
Isabel S. Oliveira ◽  
Joana Gomes ◽  
Cátia Teixeira ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Antimalarial Activity ◽  
Parent Drug ◽  
Cost Effective ◽  
Fold Increase ◽  
Pharmaceutical Ingredients ◽  
Ic50 Values ◽  
Surface Active ◽  
The Cost

Ionic liquids derived from classical antimalarials are emerging as a new approach towards the cost-effective rescuing of those drugs. Herein, we disclose novel surface-active ionic liquids derived from chloroquine and natural fatty acids whose antimalarial activity in vitro was found to be superior to that of the parent drug. The most potent ionic liquid was the laurate salt of chloroquine, which presented IC50 values of 4 and 110 nM against a chloroquine-sensitive and a chloroquine-resistant strain of Plasmodium falciparum, respectively, corresponding to an 11- and 6-fold increase in potency as compared to the reference chloroquine bisphosphate salt against the same strains. This unprecedented report opens new perspectives in both the fields of malaria chemotherapy and of surface-active ionic liquids derived from active pharmaceutical ingredients.

scholarly journals Chlorophylls Extraction from Spinach Leaves Using Aqueous Solutions of Surface-Active Ionic Liquids

2021 ◽  
Vol 2 (4) ◽  
pp. 764-777
Author(s):  
Ana M. Ferreira ◽  
Ana Cláudia Leite ◽  
João A. P. Coutinho ◽  
Mara G. Freire
Keyword(s):  
Ionic Liquids ◽  
Aqueous Solutions ◽  
Chlorophyll A ◽  
Cost Effective ◽  
Selective Extraction ◽  
Operating Conditions ◽  
Pure Ethanol ◽  
Pure Compounds ◽  
Surface Active ◽  
Spinach Leaves

Chlorophylls and their derivatives have been extensively studied due to their unique and valuable properties, including their anti-mutagenic and anti-carcinogenic features. Nevertheless, high-purity-level chlorophylls extracted from natural sources are quite expensive because the methods used for their extraction have low selectivity and result in low yields. This study aimed to develop a “greener” and cost-effective technology for the extraction of chlorophylls from biomass using aqueous solutions of ionic liquids (ILs). Several aqueous solutions of ILs, with hydrotropic and surface-active effects were evaluated, demonstrating that aqueous solutions of surface-active ILs are enhanced solvents for the extraction of chlorophylls from spinach leaves. Operating conditions, such as the IL concentration and solid–liquid ratio, were optimized by a response surface methodology. Outstanding extraction yields (0.104 and 0.022 wt.% for chlorophyll a and b, respectively, obtained simultaneously) and selectivity (chlorophyll a/b ratio of 4.79) were obtained with aqueous solutions of hexadecylpyridinium chloride ([C16py]Cl) at moderate conditions of temperature and time. These extraction yields are similar to those obtained with pure ethanol. However, the chlorophyll a/b ratio achieved with the IL aqueous solution is higher than with pure ethanol (3.92), reinforcing the higher selectivity afforded by IL aqueous solutions as viable replacements to volatile organic compounds and allowing the obtainment of more pure compounds. Finally, the recovery and reuse of the solvent were evaluated by using a back-extraction step of chlorophylls using ethyl acetate. The results disclosed here bring new perspectives into the design of new approaches for the selective extraction of chlorophylls from biomass using aqueous solutions of surface-active ILs.

Relationship between structure and biodegradability of gemini imidazolium surface active ionic liquids

2019 ◽  
Vol 278 ◽  
pp. 145-155 ◽  
Author(s):  
Guowei Wang ◽  
Xiaoqing Xu ◽  
Yu Sun ◽  
Linghua Zhuang ◽  
Cheng Yao
Keyword(s):  
Ionic Liquids ◽  
Surface Active ◽  
Gemini Imidazolium

scholarly journals Ecotoxicity profiling of a library of 24 l-phenylalanine derived surface-active ionic liquids (SAILs)

2021 ◽  
Vol 19 ◽  
pp. 100369
Author(s):  
Dewi K.A. Kusumahastuti ◽  
Mariliis Sihtmäe ◽  
Villem Aruoja ◽  
Nicholas Gathergood ◽  
Anne Kahru
Keyword(s):  
Ionic Liquids ◽  
Surface Active

Herbicidal ionic liquids derived from renewable sources

RSC Advances ◽  
2016 ◽  
Vol 6 (58) ◽  
pp. 52781-52789 ◽  
Author(s):  
Juliusz Pernak ◽  
Kamil Czerniak ◽  
Agnieszka Biedziak ◽  
Katarzyna Marcinkowska ◽  
Tadeusz Praczyk ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Renewable Sources ◽  
New Family ◽  
Surface Active

A new family of herbicidal ionic liquids based on d-glucose and MCPA or 2,4-D anions has been synthesized and the physicochemical, surface active and herbicidal properties of the obtained salts were characterized.

Aggregation Behaviours of Surface-Active Ionic Liquids 1-Alkyl-3-methylimidazolium Bis(2-ethylhexyl)sulfosuccinate

2016 ◽  
Vol 69 (11) ◽  
pp. 1254 ◽  
Author(s):  
Jiequn Wu ◽  
Tianxiang Yin ◽  
Shaoxiong Shi ◽  
Weiguo Shen
Keyword(s):  
Ionic Liquids ◽  
Self Assembly ◽  
Alkyl Chain ◽  
Systematic Investigation ◽  
Bulk Solution ◽  
Free Energies ◽  
Imidazolium Cation ◽  
Structure Transition ◽  
Surface Active ◽  
Counter Ion Binding

The systematic investigation of the aggregation behaviours of newly synthesised surface-active ionic liquids 1-alkyl-3-methylimidazolium bis(2-ethylhexyl)sulfosuccinate ([Cnmim][AOT], n = 2, 3, 5, 6, 7) by various techniques is reported. The critical aggregation concentrations (CACs) and the standard Gibbs free energies of aggregation () were determined from measurements on conductivity, fluorescence, and surface tension, which suggested a stronger self-assembly ability in the bulk solution for [Cnmim][AOT] surfactants with longer alkyl chain cations. An interesting structure transition driven by the penetration of the imidazolium cation into the aggregate when n > 4 was found by analysis of the variations of the values of CAC, , the degree of counter ion binding (β), and the micropolarity (I1/I3) immediately after the CAC with changing alkyl chain length of the imidazolium cation, which was further confirmed by 1H NMR measurements.

Impact of Surface Active Ionic Liquids on the Cloud Points of Nonionic Surfactants and the Formation of Aqueous Micellar Two-Phase Systems

2017 ◽  
Vol 121 (37) ◽  
pp. 8742-8755 ◽  
Author(s):  
Filipa A. Vicente ◽  
Inês S. Cardoso ◽  
Tânia E. Sintra ◽  
Jesus Lemus ◽  
Eduardo F. Marques ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Nonionic Surfactants ◽  
Two Phase ◽  
Cloud Points ◽  
Surface Active ◽  
Phase Systems
Sign in / Sign up

Export Citation Format

Share Document