scholarly journals A different pattern of cytotoxic T lymphocyte recognition against primary and metastatic tumor cells in a patient with nonsmall cell lung carcinoma

Cancer ◽  
2004 ◽  
Vol 103 (1) ◽  
pp. 200-208 ◽  
Author(s):  
Tetsuya So ◽  
Mitsuhiro Takenoyama ◽  
Yoshinobu Ichiki ◽  
Makiko Mizukami ◽  
Tomoko So ◽  
...  
Keyword(s):  
Tumor Cells ◽  
T Lymphocyte ◽  
Lung Carcinoma ◽  
Cytotoxic T Lymphocyte ◽  
Metastatic Tumor ◽  
Cell Lung Carcinoma ◽  
Nonsmall Cell Lung Carcinoma

scholarly journals Nonsmall Cell Lung Carcinoma with Giant Cell Features Expressing Programmed Death-Ligand 1: A Report of a Patient Successfully Treated with Pembrolizumab

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Shingo Nakayama ◽  
Mamoru Sasaki ◽  
Shojiroh Morinaga ◽  
Naoto Minematsu
Keyword(s):  
Brain Metastases ◽  
Cell Carcinoma ◽  
Giant Cell ◽  
Tumor Cells ◽  
Lung Carcinoma ◽  
Cell Lung Carcinoma ◽  
Programmed Death Ligand 1 ◽  
Giant Cell Carcinoma ◽  
Nonsmall Cell Lung Carcinoma ◽  
Programmed Death

Giant cell carcinoma, a rare variant of nonsmall cell lung carcinoma (NSCLC), is characterized by aggressive progression and poor response to conventional chemotherapy. This report is the first to describe a patient with NSCLC and giant cell features who was successfully treated with pembrolizumab, an antibody targeting programmed death-1 (PD-1). A 69-year-old woman was diagnosed with NSCLC with multiple brain metastases. Histological evaluation of lung biopsy specimens revealed proliferation of pleomorphic giant tumor cells with poor cohesiveness, findings consistent with giant cell carcinoma. Immunostaining showed that a high proportion of the tumor cells were positive for expression of programmed death-ligand 1 (PD-L1). The patient received stereotactic radiotherapy for the brain metastases, followed by administration of pembrolizumab. Treatment with pembrolizumab resulted in the rapid regression of the primary lung nodule, with the progression-free period maintained for at least four treatment cycles. Immunotherapy targeting PD-1/PD-L1 may be an option for patients with PD-L1-positive NSCLC with giant cell features.

scholarly journals Patterns of relapse of N2 nonsmall-cell lung carcinoma patients treated with preoperative chemotherapy

Cancer ◽  
2001 ◽  
Vol 91 (12) ◽  
pp. 2394-2400 ◽  
Author(s):  
F. Andre ◽  
D. Grunenwald ◽  
J. L. Pujol ◽  
P. Girard ◽  
A. Dujon ◽  
...  
Keyword(s):  
Preoperative Chemotherapy ◽  
Lung Carcinoma ◽  
Cell Lung Carcinoma ◽  
Nonsmall Cell Lung Carcinoma

scholarly journals Cytokeratin-positive interstitial reticulum cell (CIRC) tumor in the lymph node: a case report of the transformation from the epithelioid cell type to the spindle cell type

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Sachiko Kaji ◽  
Nobuyuki Hiruta ◽  
Daisuke Sasai ◽  
Makoto Nagashima ◽  
Rintaro Ohe ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Lung Carcinoma ◽  
Spindle Cell ◽  
Small Cell Lung Carcinoma ◽  
Epithelioid Cell ◽  
Small Cell ◽  
Cell Type ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Spindle Cell Type

Abstract Background Cytokeratin-positive interstitial reticulum cells (CIRCs), which are a subgroup of fibroblastic reticular cells (FRCs), are known to be present in the lymph nodes. There have been only a few cases of tumors derived from CIRCs. Case presentation We have reported a new case involving a CIRC tumor in a 75-year-old man and reviewed the literature. The resected mediastinal lymph nodes showed epithelial-like proliferation of large atypical round and polygonal epithelioid cells. The tumor cells expressed CK8, CK18, CAM5.2, AE1/AE3, epithelial membrane antigen, vimentin, fascin, and some FRC markers, which is consistent with the diagnosis of a CIRC tumor. Following chemotherapy, the CIRC tumor was observed to have responded very well and became difficult to confirm on imaging, but a small cell lung carcinoma developed 12 months later. Chemoradiotherapy was performed, but the patient passed away 29 months after the initial diagnosis. The autopsy revealed the recurrence of the CIRC tumor, residual small cell lung carcinoma, and a very small latent carcinoma of the prostate. The relapsed CIRC tumor cells had a spindle shape; they were highly pleomorphic and had invaded the superior vena cava. Conclusion We first reported autopsy findings of CIRC tumors and demonstrated the transformation of the tumor from the epithelioid cell type to the spindle cell type.

scholarly journals Is quality of life predictive of the survival of patients with advanced nonsmall cell lung carcinoma?

Cancer ◽  
1999 ◽  
Vol 85 (2) ◽  
pp. 333-340 ◽  
Author(s):  
James E. Herndon ◽  
Stewart Fleishman ◽  
Alice B. Kornblith ◽  
Michael Kosty ◽  
Mark R. Green ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Carcinoma ◽  
Cell Lung Carcinoma ◽  
Nonsmall Cell Lung Carcinoma

Analysis of Young and Elderly Advanced Stage Nonsmall-Cell Lung Carcinoma Cases

2009 ◽  
Vol 102 (10) ◽  
pp. 1019-1022 ◽  
Author(s):  
Sibel Arinc ◽  
Ferah Ece ◽  
Muyesser Ertugrul ◽  
Nuray Erdal ◽  
Ozlem Oruc ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Advanced Stage ◽  
Cell Lung Carcinoma ◽  
Nonsmall Cell Lung Carcinoma

Interaction Of Platelets And Tumor Cells: Differentiation Between Nine Human Tumor Cell Lines Based On Aggregation And Effects Of Apyrase, Hirudin And Phospholipase D

1981 ◽  
Author(s):  
G A Jamieson ◽  
Eva Bastida ◽  
Antonio Ordinas
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Cell Lines ◽  
Phospholipase D ◽  
Lung Carcinoma ◽  
Platelet Rich Plasma ◽  
Human Tumor ◽  
Clotting System ◽  
Cell Lung Carcinoma ◽  
Aggregation Pattern

Aggregation mechanisms have been examined in a homologous system using heparinized human platelet-rich plasma with cell lines derived from human tumors. The A549 (epithelial lung carcinoma) and Hut23 (adenocarcinoma) did not aggregate platelets at 107 cells/ml. Other cell lines could not be classified by aggregation pattern alone since all gave biphasic or quasibiphasic patterns. HT 29 (adenocarcinoma) , SKBR3 (adenocarcinoma), HT 144 (melanoma) and Hut 20 (large cell lung carcinoma) were inhibited by apyrase and phospholipase D but not by hirudin: aggregation induced by this group is probably primarily dependent on ADP. Aggregation by SKNMC (mesothelioma) and Hut 28 (mesothelioma) was inhibited by hirudin and phospholipase D but not by apyrase. Aggregation by this second group probably involves activation of the clotting system in the early stages but can be differentiated from a similar mechanism with U87MG since thq latter is not inhibited by phospholipase D. Phospholipase C had no effect on any cell line and phospholipase A2 inhibited all cell lines, as did its hydrolytic product, lysolecthin. Platelet aggregating material (PAM) could not be isolated by urea extraction of any of these human tumor cells. These results suggest that various inhibitors are necessary to allow classification of mechanisms of tumor cell-induced platelet aggregation.

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