scholarly journals Quo vadis: Advanced prostate cancer-clinical care and clinical research in the era of multiple androgen receptor-directed therapies

Cancer ◽  
2014 ◽  
Vol 121 (3) ◽  
pp. 361-371 ◽  
Author(s):  
Won Kim ◽  
Charles J. Ryan
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Clinical Research ◽  
Advanced Prostate Cancer ◽  
Clinical Care ◽  
Quo Vadis

scholarly journals Quo Vadis Advanced Prostate Cancer Therapy? Novel Treatment Perspectives and Possible Future Directions

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2228
Author(s):  
Jana Kvízová ◽  
Vladimíra Pavlíčková ◽  
Eva Kmoníčková ◽  
Tomáš Ruml ◽  
Silvie Rimpelová
Keyword(s):  
Prostate Cancer ◽  
Advanced Prostate Cancer ◽  
Kinase Inhibitors ◽  
Diagnostic Methods ◽  
Common Disease ◽  
Cyclin Dependent Kinase ◽  
Future Directions ◽  
Prostate Cancer Therapy ◽  
Quo Vadis ◽  
Antiandrogen Therapy

Prostate cancer is a very common disease, which is, unfortunately, often the cause of many male deaths. This is underlined by the fact that the early stages of prostate cancer are often asymptomatic. Therefore, the disease is usually detected and diagnosed at late advanced or even metastasized stages, which are already difficult to treat. Hence, it is important to pursue research and development not only in terms of novel diagnostic methods but also of therapeutic ones, as well as to increase the effectiveness of the treatment by combinational medicinal approach. Therefore, in this review article, we focus on recent approaches and novel potential tools for the treatment of advanced prostate cancer; these include not only androgen deprivation therapy, antiandrogen therapy, photodynamic therapy, photothermal therapy, immunotherapy, multimodal therapy, but also poly(ADP-ribose) polymerase, Akt and cyclin-dependent kinase inhibitors.

scholarly journals A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer

Cell ◽  
2018 ◽  
Vol 174 (2) ◽  
pp. 422-432.e13 ◽  
Author(s):  
David Y. Takeda ◽  
Sándor Spisák ◽  
Ji-Heui Seo ◽  
Connor Bell ◽  
Edward O’Connor ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Advanced Prostate Cancer

Abstract B14: Developing small-molecule inhibitors to the androgen receptor N-terminus domain for the treatment of advanced prostate cancer

2012 ◽  
Vol 72 (4 Supplement) ◽  
pp. B14-B14
Author(s):  
Marianne D. Sadar ◽  
Jae-Kyung Myung ◽  
Iain McEwan ◽  
Stephen Plymate ◽  
Raymond J. Andersen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Small Molecule ◽  
Advanced Prostate Cancer ◽  
Small Molecule Inhibitors ◽  
N Terminus

scholarly journals Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer

2019 ◽  
Vol 145 (2) ◽  
pp. 415-426 ◽  
Author(s):  
Qipeng Liu ◽  
Guangyu Wang ◽  
Qiaqia Li ◽  
Weihua Jiang ◽  
Jung‐Sun Kim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Advanced Prostate Cancer ◽  
Polycomb Group ◽  
Polycomb Group Proteins
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