Erratum: Connor RM, Allen CL, Devine CA, Claxton C, Key B. 2005. BOC, brother of CDO, is a dorsoventral axon-guidance molecule in the embryonic vertebrate brain. J Comp Neurol 485:32-42

A scaffold of axons consisting of a pair of longitudinal tracts and several commissures is established during early development of the vertebrate brain. We report here that NOC-2, a cell surface carbohydrate, is selectively expressed by a subpopulation of growing axons in this scaffold in Xenopus. NOC-2 is present on two glycoproteins, one of which is a novel glycoform of the neural cell adhesion molecule N-CAM. When the function of NOC-2 was perturbed using either soluble carbohydrates or anti-NOC-2 antibodies, axons expressing NOC-2 exhibited aberrant growth at specific points in their pathway. NOC-2 is the first-identified axon guidance molecule essential for development of the axon scaffold in the embryonic vertebrate brain.

Download Full-text

BOC, brother of CDO, is a dorsoventral axon-guidance molecule in the embryonic vertebrate brain

The Journal of Comparative Neurology ◽

10.1002/cne.20503 ◽

2005 ◽

Vol 485 (1) ◽

pp. 32-42 ◽

Cited By ~ 18

Author(s):

Robin M. Connor ◽

Chelsea L. Allen ◽

Christine A. Devine ◽

Christina Claxton ◽

Brian Key

Keyword(s):

Axon Guidance ◽

Vertebrate Brain ◽

Axon Guidance Molecule ◽

Guidance Molecule

Download Full-text

3GnT2 Maintains Adenylyl Cyclase-3 Signaling and Axon Guidance Molecule Expression in the Olfactory Epithelium

Journal of Neuroscience ◽

10.1523/jneurosci.0224-11.2011 ◽

2011 ◽

Vol 31 (17) ◽

pp. 6576-6586 ◽

Cited By ~ 16

Author(s):

T. R. Henion ◽

A. A. Faden ◽

T. K. Knott ◽

G. A. Schwarting

Keyword(s):

Axon Guidance ◽

Adenylyl Cyclase ◽

Olfactory Epithelium ◽

Axon Guidance Molecule ◽

Guidance Molecule

Download Full-text

The Beat generation: a multigene family encoding IgSF proteins related to the Beat axon guidance molecule in Drosophila

Development ◽

10.1242/dev.128.22.4545 ◽

2001 ◽

Vol 128 (22) ◽

pp. 4545-4552 ◽

Cited By ~ 1

Author(s):

G. C. Teg Pipes ◽

Qing Lin ◽

Stephanie E. Riley ◽

Corey S. Goodman

Keyword(s):

Axon Guidance ◽

Specific Growth ◽

Growth Cones ◽

Beat Generation ◽

Genetic Screen ◽

Genetic Interactions ◽

Membrane Bound ◽

Adhesive Factor ◽

Axon Guidance Molecule ◽

Guidance Molecule

A previous genetic screen led to the identification of the beaten path (beat Ia) gene in Drosophila. Beat Ia contains two immunoglobulin (Ig) domains and appears to function as an anti-adhesive factor secreted by specific growth cones to promote axon defasciculation. We identify a family of 14 beat-like genes in Drosophila. In contrast to beat Ia, four novel Beat-family genes encode membrane-bound proteins. Moreover, mutations in each gene lead to much more subtle guidance phenotypes than observed in beat Ia. Genetic interactions between beat Ic and beat Ia reveal complementary functions. Our data suggest a model whereby Beat Ic (and perhaps other membrane-bound family members) functions in a pro-adhesive fashion to regulate fasciculation, while Beat Ia (the original secreted Beat) functions in an anti-adhesive fashion to regulate defasciculation.

Download Full-text