Paralysis elicited by spinal cord injury evokes selective disassembly of neuromuscular synapses with and without terminal sprouting in ankle flexors of the adult rat

2006 ◽  
Vol 500 (1) ◽  
pp. 116-133 ◽  
Author(s):  
Anthony S. Burns ◽  
Sabiha Jawaid ◽  
Hui Zhong ◽  
Hiroyuki Yoshihara ◽  
Srishti Bhagat ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Adult Rat ◽  
Neuromuscular Synapses ◽  
Cord Injury ◽  
Selective Disassembly

scholarly journals Intraspinal Transplantation of hNT Neurons in the Lesioned Adult Rat Spinal Cord

2004 ◽  
Vol 31 (1) ◽  
pp. 87-96 ◽  
Author(s):  
Sean Dennis Christie ◽  
Damaso Sadi ◽  
Ivar Mendez
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuron Specific Enolase ◽  
Neural Transplantation ◽  
Adult Rat ◽  
Tissue Source ◽  
Human Neurons ◽  
Cord Injury ◽  
Female Wistar Rats ◽  
Immunohistochemical Studies

Background:The role of neural transplantation as a restorative strategy for spinal cord injury continues to be intensely investigated. Ideally, the tissue source for transplantation must be readily available, free of disease and able to survive and mature following implantation into the adverse environment created by the injury. We have studied the use of a commercially available cell line of cultured human neurons (hNT neurons) as a tissue source for neural transplantation in spinal cord injury.Methods:Following a left lateral thoracic hemisection, 54 immunosuppressed, female Wistar rats were randomly allocated into different treatment groups; hemisection only or hemisection and hNT cell transplantation (via a bridge, double or triple graft). Grafting occurred three days after spinal cord injury. After thirteen weeks the animals were sacrificed and tissue sections were stained with human neuron specific enolase and human specific neural cell adhesion molecule.Results:Immunohistochemical evidence of graft survival was displayed in 66.7% of the surviving, grafted animals. Fibre outgrowth, greatest in the bridge and triple grafts, was observed in both rostral and caudal directions essentially bridging the lesion. Double grafts were smaller, displaying less fibre outgrowth, which did not cross the lesion. Long fibre outgrowth was evident up to 2 cm from the graft as assessed by tracing and immunohistochemical studies.Conclusion:Bridge and triple grafts displayed greater growth and enabled the hNT graft to essentially bridge the lesion. This suggests that hNT neurons have the potential to structurally reconnect the proximal and distal spinal cord across the region of injury.

scholarly journals Single pellet grasping following cervical spinal cord injury in adult rat using an automated full-time training robot

2016 ◽  
Vol 299 ◽  
pp. 59-71 ◽  
Author(s):  
Keith K. Fenrich ◽  
Zacincte May ◽  
Abel Torres-Espín ◽  
Juan Forero ◽  
David J. Bennett ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Full Time ◽  
Adult Rat ◽  
Single Pellet ◽  
Cord Injury

PRDM5 Expression and Essential Role After Acute Spinal Cord Injury in Adult Rat

2016 ◽  
Vol 41 (12) ◽  
pp. 3333-3343 ◽  
Author(s):  
Jie Liu ◽  
Weijie Wu ◽  
Jie Hao ◽  
Mingchen Yu ◽  
Jin Liu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Essential Role ◽  
Acute Spinal Cord Injury ◽  
Adult Rat ◽  
Cord Injury

scholarly journals Comprehensive locomotor outcomes correlate to hyperacute diffusion tensor measures after spinal cord injury in the adult rat

2012 ◽  
Vol 235 (1) ◽  
pp. 188-196 ◽  
Author(s):  
Joong H. Kim ◽  
Sheng-Kwei Song ◽  
Darlene A. Burke ◽  
David S.K. Magnuson
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor ◽  
Adult Rat ◽  
Cord Injury

Expression of G-protein-coupled receptor kinase 6 (GRK6) after acute spinal cord injury in adult rat

2013 ◽  
Vol 44 (3) ◽  
pp. 259-270 ◽  
Author(s):  
Binbin Sun ◽  
Yilu Gao ◽  
Dong Lou ◽  
Xiujie Wu ◽  
Haixiang Wei ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
G Protein ◽  
Acute Spinal Cord Injury ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Adult Rat ◽  
Cord Injury ◽  
G Protein Coupled

FOXO3a/p27kip1expression and essential role after acute spinal cord injury in adult rat

2012 ◽  
Vol 114 (2) ◽  
pp. 354-365 ◽  
Author(s):  
Shuangwei Zhang ◽  
Weipeng Huan ◽  
Haixiang Wei ◽  
Jinlong Shi ◽  
Jinpeng Fan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Essential Role ◽  
Acute Spinal Cord Injury ◽  
Adult Rat ◽  
Cord Injury
Sign in / Sign up

Export Citation Format

Share Document