Ex Vivo Whole Nerve Electrophysiology Setup, Action Potential Recording, and Data Analyses in a Rodent Model

2020 ◽  
Vol 93 (1) ◽  
Author(s):  
Sharon Sun ◽  
Jorge Delgado ◽  
Negin Behzadian ◽  
David Yeomans ◽  
Thomas Anthony Anderson
Keyword(s):  
Action Potential ◽  
Ex Vivo ◽  
Rodent Model ◽  
Data Analyses ◽  
Potential Recording

In Vivo Whole‐Nerve Electrophysiology Setup, Action Potential Recording, and Data Analyses in a Rodent Model

2021 ◽  
Vol 1 (11) ◽  
Author(s):  
Diane Zhao ◽  
Negin Behzadian ◽  
David Yeomans ◽  
T. Anthony Anderson
Keyword(s):  
Action Potential ◽  
Rodent Model ◽  
Data Analyses ◽  
Potential Recording

Change of propagation speed of action potential in axons bunch of frog"s somatic nerve ex vivo and processes of inactivation under local laser influence

2005 ◽  
Author(s):  
Alexander G. Akchurin ◽  
Garif G. Akchurin ◽  
Roman P. Gorshkov ◽  
Leonid A. Melnikov ◽  
Vyacheslav G. Ninel ◽  
...  
Keyword(s):  
Action Potential ◽  
Ex Vivo ◽  
Propagation Speed ◽  
Somatic Nerve

Evidence for electrical remodelling of the atrial myocardium in patients with atrial fibrillation. A study using the monophasic action potential recording technique

2002 ◽  
Vol 22 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Eva J. Hertervig ◽  
Shiwen Yuan ◽  
Jonas Carlson ◽  
Ole Kongstad-Rasmussen ◽  
S. Bertil Olsson
Keyword(s):  
Atrial Fibrillation ◽  
Action Potential ◽  
Monophasic Action Potential ◽  
Atrial Myocardium ◽  
Recording Technique ◽  
Potential Recording

An organic transistor matrix for multipoint intracellular action potential recording

2021 ◽  
Vol 118 (39) ◽  
pp. e2022300118
Author(s):  
Yasutoshi Jimbo ◽  
Daisuke Sasaki ◽  
Takashi Ohya ◽  
Sunghoon Lee ◽  
Wonryung Lee ◽  
...  
Keyword(s):  
Action Potential ◽  
Organic Electronics ◽  
Field Potential ◽  
Driving Voltage ◽  
Electrode Arrays ◽  
Access Methods ◽  
Intracellular Action Potential ◽  
Electrochemical Transistor ◽  
Potential Recording ◽  
Intracellular Action

Electrode arrays are widely used for multipoint recording of electrophysiological activities, and organic electronics have been utilized to achieve both high performance and biocompatibility. However, extracellular electrode arrays record the field potential instead of the membrane potential itself, resulting in the loss of information and signal amplitude. Although much effort has been dedicated to developing intracellular access methods, their three-dimensional structures and advanced protocols prohibited implementation with organic electronics. Here, we show an organic electrochemical transistor (OECT) matrix for the intracellular action potential recording. The driving voltage of sensor matrix simultaneously causes electroporation so that intracellular action potentials are recorded with simple equipment. The amplitude of the recorded peaks was larger than that of an extracellular field potential recording, and it was further enhanced by tuning the driving voltage and geometry of OECTs. The capability of miniaturization and multiplexed recording was demonstrated through a 4 × 4 action potential mapping using a matrix of 5- × 5-μm2 OECTs. Those features are realized using a mild fabrication process and a simple circuit without limiting the potential applications of functional organic electronics.

Verification of a Rapidly Multiplexed Circuit for Scalable Action Potential Recording

2020 ◽  
Author(s):  
Mohit Sharma ◽  
Hunter J. Strathman ◽  
Ross M. Walker
Keyword(s):  
Action Potential ◽  
Potential Recording

scholarly journals A minimally invasive catheter-based ultrasound technology for therapeutic interventions in brain: initial preclinical studies

2018 ◽  
Vol 44 (2) ◽  
pp. E13 ◽  
Author(s):  
Goutam Ghoshal ◽  
Lucy Gee ◽  
Tamas Heffter ◽  
Emery Williams ◽  
Corinne Bromfield ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Minimally Invasive ◽  
Focused Ultrasound ◽  
Ex Vivo ◽  
Experimental Studies ◽  
Rodent Model ◽  
Therapeutic Interventions ◽  
Porcine Liver

OBJECTIVEMinimally invasive procedures may allow surgeons to avoid conventional open surgical procedures for certain neurological disorders. This paper describes the iterative process for development of a catheter-based ultrasound thermal therapy applicator.METHODSUsing an ultrasound applicator with an array of longitudinally stacked and angularly sectored tubular transducers within a catheter, the authors conducted experimental studies in porcine liver, in vivo and ex vivo, in order to characterize the device performance and lesion patterns. In addition, they applied the technique in a rodent model of Parkinson’s disease to investigate the feasibility of its application in brain.RESULTSThermal lesions with multiple shapes and sizes were readily achieved in porcine liver. The feasibility of catheter-based focused ultrasound in the treatment of brain conditions was demonstrated in a rodent model of Parkinson’s disease.CONCLUSIONSThe authors show proof of principle of a catheter-based ultrasound system that can create lesions with concurrent thermode-based measurements.

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