In Vitro Permeation Test (IVPT) for Pharmacokinetic Assessment of Topical Dermatological Formulations

2020 ◽  
Vol 91 (1) ◽  
Author(s):  
Leandro L. Santos ◽  
Nathaniel J. Swofford ◽  
Brandon G. Santiago
Keyword(s):  
In Vitro Permeation ◽  
Pharmacokinetic Assessment ◽  
In Vitro Permeation Test ◽  
Permeation Test

scholarly journals Permeability of Ibuprofen in the Form of Free Acid and Salts of L-Valine Alkyl Esters from a Hydrogel Formulation through Strat-M™ Membrane and Human Skin

Materials ◽  
2021 ◽  
Vol 14 (21) ◽  
pp. 6678
Author(s):  
Joanna Klebeko ◽  
Paula Ossowicz-Rupniewska ◽  
Anna Nowak ◽  
Ewa Janus ◽  
Wiktoria Duchnik ◽  
...  
Keyword(s):  
Human Skin ◽  
Free Acid ◽  
Skin Permeation ◽  
Skin Penetration ◽  
Hplc Method ◽  
Penetration Enhancers ◽  
In Vitro Permeation ◽  
Cumulative Mass ◽  
Permeation Test

This paper aimed to evaluate the effect of vehicle and chemical modifications of the structure of active compounds on the skin permeation and accumulation of ibuprofen [IBU]. In vitro permeation experiments were performed using human abdominal skin and Strat-M™ membrane. The HPLC method was used for quantitative determinations. The formulations tested were hydrogels containing IBU and its derivatives and commercial gel with ibuprofen. The results obtained indicate that Celugel® had an enhancing effect on the skin penetration of IBU. The average cumulative mass of [IBU] after 24 h permeation test from Celugel® formulation through human skin was over 3 times higher than for the commercial product. Three ibuprofen derivatives containing [ValOiPr][IBU], [ValOPr][IBU], and [ValOBu][IBU] cation were evaluated as chemical penetration enhancers. The cumulative mass after 24 h of penetration was 790.526 ± 41.426, 682.201 ± 29.910, and 684.538 ± 5.599 μg IBU cm−2, respectively, compared to the formulation containing unmodified IBU-429.672 ± 60.151 μg IBU cm−2. This study demonstrates the perspective of the transdermal hydrogel vehicle in conjunction with the modification of the drug as a potential faster drug delivery system.

scholarly journals Formulation and Evaluation of Ketoprofen Gel Preparations, Sesami Oil Soybean Oil and Oleic Acid as Enhancers

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Rugun Clara Samosir ◽  
Iyan Sopyan ◽  
Dolih Gozali
Keyword(s):  
Oleic Acid ◽  
Soybean Oil ◽  
Sesame Oil ◽  
Drug Formulation ◽  
Diffusion Cell ◽  
Drug Penetration ◽  
Franz Diffusion Cell ◽  
In Vitro Permeation ◽  
Permeation Test

Permeation is a measurable profile in drug penetration in skin. Adding increasing permeation substance (enhancer) in drug formulation is an important thing in pharmaceutical and toxicology in nowadays. The purpose of this research was to evaluate the effect of sesame oil, soybean oil, and oleic acid as enhancer in ketoprofen gel permeation. Six formula were prepared by varying concentration of sesame oil, soybean oil, and oleic acid respectively 5% and 10% and one blank, without enhancer. Permeation test was evaluated by in vitro permeation test using Franz diffusion cell method and shed snake skin of reticulated python as a membrane. Permeation test were carried out for 6 hours. The result showed that sesame oil, soybean oil, and oleic acid were able to increase ketoprofen permeation. B1 formula that contain 5% sesame oil had greatest percent permeation after 6 hours is 5.913%, while blank that contain no enhancer is 0.623%.Keywords: ketoprofen, permeation, enhancer, soybean oil, sesame oil, oleic acid.

In vitro permeation, skin-layers distribution and environmental emission of bioactive Tea Tree essential oil components from topic formulations

2019 ◽  
Author(s):  
B Sgorbini ◽  
F Capetti ◽  
C Cagliero ◽  
A Marengo ◽  
M Argenziano ◽  
...  
Keyword(s):  
Essential Oil ◽  
Tea Tree ◽  
In Vitro Permeation ◽  
Oil Components

Formulation and Evaluation of Carbopol Gel Containing Liposomes of Ketoconazole. (Part-II)

2009 ◽  
Vol 1 (2) ◽  
Author(s):  
Rakesh Patel ◽  
Hardik Patel ◽  
Ashok Baria
Keyword(s):  
Antifungal Activity ◽  
Rat Skin ◽  
Albino Rat ◽  
In Vitro Drug Release ◽  
Carbopol Gel ◽  
Liposomal Formulations ◽  
Release Drug ◽  
In Vitro Permeation ◽  
In Vitro Antifungal Activity

The aim of this work was to prepare and evaluate the topical carbopol gel formulation containing ketoconazole encapsulated liposomes. Ketoconazole loaded liposomes were prepared by thin film hydration technique. The prepared liposomes were incorporated into 1% carbopol gel, and the systems were evaluated for in-vitro drug release, drug retention into skin and in-vitro antifungal activity. The in-vitro permeation of ketoconazole using wistar albino rat skin from liposomal gel was compared with that of plain drug gel and also with plain drug cream containing 2% w/w of ketoconazole. The release of ketoconazole from liposomal gel was much slower than from non liposomal formulations. Gel containing liposomal ketoconazole showed maximum antifungal activity after 30 hours over plain ketoconazole gel and cream formulations.

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