Regulatory Considerations and Streamlined Development Programs for Antibacterial Drugs for Serious Bacterial Diseases

2021 ◽  
Author(s):  
Seong H. Jang
Keyword(s):  
Development Programs ◽  
Antibacterial Drugs ◽  
Bacterial Diseases

scholarly journals Bactericidal Potential of Local Medicinal Plants of Kashmir Valley in Fishes: A Review

2021 ◽  
pp. 21-27
Author(s):  
Inain Jaies ◽  
Feroz Ahmad Shah ◽  
Shabir Ahmad Dar ◽  
Syed Shariq Nazir Qadiri ◽  
Asifa Wali ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Bacterial Infections ◽  
Antibacterial Activities ◽  
Significant Loss ◽  
Human Consumption ◽  
Kashmir Valley ◽  
Antibacterial Drugs ◽  
Bacterial Diseases ◽  
Natural Herb

Bacterial diseases in fishes create one of the alarming situations that render significant loss to the fishing industries and aquacultural farm units worldwide. Various drugs have been formulated, standardized, and used in the industry to combat bacterial infections. However, non-judicious drugs can lead to pharmacological problems and induction of toxicity in fishes, leaving them less suitable for human consumption. These drugs can be supplemented with the natural herb plants having antibacterial activities, although they cannot be used solely to curb the menace. Therefore, the review put forth an idea, which plant herbs can be used as antibacterial drugs in fishes.

scholarly journals An Analysis of Antibacterial Drug Development Trends in the United States, 1980–2019

2020 ◽  
Author(s):  
Nidhi Dheman ◽  
Nicole Mahoney ◽  
Edward M Cox ◽  
John J Farley ◽  
Thushi Amini ◽  
...  
Keyword(s):  
Drug Development ◽  
The United States ◽  
Marketing Approval ◽  
Pharmaceutical Companies ◽  
Antibacterial Drug ◽  
Development Programs ◽  
Success Rates ◽  
Development Activity ◽  
Antibacterial Drugs ◽  
Drug Classes

Abstract We present a longitudinal analysis of investigational new drug applications (INDs) for new, systemic antibacterial drugs under active development between 1980 and 2019, evaluating the characteristics of these investigational drugs and the outcomes of these drug development programs. The number of INDs in active development declined by two-thirds, from 39 active INDs at its peak in 1987 to a low 13 in 2001, with decreased development of new cephalosporin, quinolone, and macrolide drugs and reduced participation from large pharmaceutical firms. Antibacterial drug development activity rebounded substantially from 2002 to 2009, primarily led by involvement of small pharmaceutical companies. As of 31 December 2019, the number of active INDs has declined to an 11-year low, and the number of antibacterial INDs initiated with the US Food and Drug Administration during 2010–2019 was lower than any of the previous 3 decades. Antibacterial drug development programs initiated in the 1980s and 1990s had high success rates, with >40% of INDs obtaining marketing approval, in a median time of about 6 years from IND receipt to approval. For drug development programs initiated between 2000 and 2009, we found that IND-to-approval rates reduced to 23%, with median development times for approved antibacterial drugs increasing to 8.2 years. The majority of INDs in development as of 31 December 2019 come from already established drug classes, most in early stages of development, and few are sponsored by large pharmaceutical companies.

A survey of dental faculty development programs

1986 ◽  
Vol 50 (12) ◽  
pp. 728-730 ◽  
Author(s):  
WH Garbee ◽  
EA Strother ◽  
E Ferraro
Keyword(s):  
Faculty Development ◽  
Development Programs

Most Antibacterial Drugs Not Associated With Birth Defects

2010 ◽  
Vol 44 (2) ◽  
pp. 20
Author(s):  
MARY ANN MOON
Keyword(s):  
Birth Defects ◽  
Antibacterial Drugs

A review of career interventions from an educational perspective: Have investigations shed any light?

2000 ◽  
Vol 59 (4) ◽  
pp. 227-239 ◽  
Author(s):  
Lee-Ann Prideaux ◽  
Peter A. Creed ◽  
Juanita Muller ◽  
Wendy Patton
Keyword(s):  
Career Development ◽  
Intervention Studies ◽  
Future Research ◽  
Development Programs ◽  
Career Intervention ◽  
Career Interventions ◽  
International Trends ◽  
Specific Career ◽  
Education Interventions ◽  
Development Literature

Despite widespread acknowledgement of the importance of career development programs to assist students in their complex transition from school to work, very few specific career education interventions have been objectively evaluated. The aim of this paper is to highlight what the authors consider to be a conspicuous shortfall in the career development literature to date, that is, reports of methodologically sound career intervention studies carried out in actual high school settings. International trends in the world of work are briefly discussed in association with the repercussions these changes are producing for today's youth. The major portion of this article is devoted to a comprehensive review of career intervention studies with particular attention paid to the methodological and theoretical issues that resonate from this review process. Recommendations for future research are proposed.

Sign in / Sign up

Export Citation Format

Share Document