Simultaneous Determination of Uranium and Depleted Uranium Isotopic Ratio Using Inductively Coupled Mass Spectrometry

2018 ◽  
Vol 78 (1) ◽  
pp. e59
Author(s):  
Maria A. Velez-Quinones ◽  
Hanna Xu ◽  
Nhu Vo ◽  
Joanna M. Gaitens ◽  
Melissa A. McDiarmid ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Simultaneous Determination ◽  
Isotopic Ratio ◽  
Depleted Uranium ◽  
Inductively Coupled ◽  
Inductively Coupled Mass Spectrometry

scholarly journals tudy on the determination of ¹⁰B/¹¹B isotope ratio in water samples by isotope dilution – inductively coupled plasma mass spectrometry (ID-ICPMS)

2021 ◽  
Vol 7 (3) ◽  
pp. 8-16
Author(s):  
Kim Dung Nguyen Thi ◽  
Thi Lien Nguyen
Keyword(s):  
Mass Spectrometry ◽  
Isotope Dilution ◽  
Water Samples ◽  
Inductively Coupled Plasma ◽  
Isotope Ratio ◽  
Isotopic Ratio ◽  
Primary Coolant ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

The determination of 10B/11B isotope ratio and boron concentration in various watersamples using isotope dilution technique with inductively coupled plasma mass spectrometry (ICPMS) was studied. The interferences on precision and accuracy in isotopic ratio determination by ICPMS such as memory effects, dead time, spectral overlap of 12C were investigated for the selection of optimum conditions. By the addition of certain amounts of enriched 10B into samples, the 10B/11B ratio was determined through ICP-MS signal of 10B and 11B. The detection limit for 10B and 11B was experimentally obtained as 0.26 µg/L and 0.92 µg/L, respectively. The ratios of 10B/11B in measured water samples varied in the ranged between 0.1905 and 0.2484 for different matrices. This method has been then applied for the determination of boron isotopic ratio in VVER-1000 reactor-type simulated primary coolant water and in some environmental water samples.

scholarly journals Simultaneous Determination of α-Fetoprotein and Free β-Human Chorionic Gonadotropin by Element-Tagged Immunoassay with Detection by Inductively Coupled Plasma Mass Spectrometry

2004 ◽  
Vol 50 (7) ◽  
pp. 1214-1221 ◽  
Author(s):  
Sichun Zhang ◽  
Chao Zhang ◽  
Zhi Xing ◽  
Xinrong Zhang
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibodies ◽  
Simultaneous Determination ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Inductively Coupled Plasma ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Abstract Background: An inductively coupled plasma mass spectrometry (ICP-MS)-based immunoassay has been proposed independently by Baranov et al. (Anal Chem 2002;74:1629–36) and our group, but the applicability of this method for multianalyte analysis in clinical samples has not been fully illustrated. We developed a dual-label immunoassay method for the simultaneous determination of α-fetoprotein (AFP) and free β-human chorionic gonadotropin (hCGβ) in human serum. Methods: Monoclonal antibodies immobilized on microtiter plates captured AFP and hCGβ, which were detected by use of Eu3+-labeled anti-AFP and Sm3+-labeled anti-hCGβ monoclonal antibodies. Eu3+ and Sm3+ were dissociated from the immunocomplex with HNO3 solution (10 mL/L) and delivered by peristaltic pump to the ICP mass spectrometer. Results: The measurable ranges of AFP and hCGβ were 4.6–500 and 5.0–170 μg/L, respectively, with detection limits of 1.2 and 1.7 μg/L (3 SD above mean of zero calibrator), respectively. The intraassay imprecision (CV) for AFP was 8.3%, 4.0%, and 2.7% at 16.3, 86, and 354 μg/L, respectively, and the interassay CV was 10%, 5.7%, and 3.5%. For hCGβ, the intraassay CV was 5.4%, 6.4%, and 3.1%, respectively, at 10.5, 45.2, and 105 μg/L, and the interassay CV was 7.2%, 8.0%, and 3.7%. Comparison with IRMAs for AFP and hCGβ yielded correlation coefficients (r2) of 0.97 and 0.95. Conclusions: Two proteins can be measured simultaneously by immunoassays using two rare earth elemental tags (Eu3+ and Sm3+) and ICP-MS detection. The multielement capability and the multiple potential elemental labels make ICP-MS attractive for multianalyte immunoassays. Implementation of ICP-MS-linked immunoassays may be relatively straightforward because the labeling and immunoreaction procedures have been well developed for clinical time-resolved immunofluorometric assays.

Simultaneous determination of arsenic and selenium species in fish tissues using microwave-assisted enzymatic extraction and ion chromatography–inductively coupled plasma mass spectrometry

Talanta ◽  
2009 ◽  
Vol 78 (3) ◽  
pp. 983-990 ◽  
Author(s):  
Laura Hinojosa Reyes ◽  
Jorge L. Guzmán Mar ◽  
G.M. Mizanur Rahman ◽  
Bryan Seybert ◽  
Timothy Fahrenholz ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Simultaneous Determination ◽  
Ion Chromatography ◽  
Inductively Coupled Plasma ◽  
Enzymatic Extraction ◽  
Fish Tissues ◽  
Inductively Coupled ◽  
Microwave Assisted ◽  
Plasma Mass Spectrometry
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