scholarly journals Trophic effects of multiple administration of mesenchymal stem cells in children with osteogenesis imperfecta

2021 ◽  
Vol 11 (4) ◽  
Author(s):  
Sowmya Ramesh ◽  
Dolly Daniel ◽  
Cecilia Götherström ◽  
Vrisha Madhuri
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenesis Imperfecta ◽  
Trophic Effects ◽  
Multiple Administration

scholarly journals Human mesenchymal stem cells provide protection against radiation-induced liver injury by antioxidative process, vasculature protection, hepatocyte differentiation and trophic effects

Cytotherapy ◽  
2014 ◽  
Vol 16 (4) ◽  
pp. S35-S36 ◽  
Author(s):  
S. Francois ◽  
M. Mouiseddine ◽  
B. Allenet-Lepage ◽  
J. Voswinkel ◽  
L. Douay ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Injury ◽  
Human Mesenchymal Stem Cells ◽  
Hepatocyte Differentiation ◽  
Trophic Effects ◽  
Radiation Induced

scholarly journals Prenatal transplantation of mesenchymal stem cells to treat osteogenesis imperfecta

2014 ◽  
Vol 5 ◽  
Author(s):  
Jerry K. Y. Chan ◽  
Cecilia Götherström
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenesis Imperfecta

Gene expression profiling of bone marrow mesenchymal stem cells from Osteogenesis Imperfecta patients during osteoblast differentiation

2017 ◽  
Vol 60 (6) ◽  
pp. 326-334 ◽  
Author(s):  
Carla Martins Kaneto ◽  
Patrícia S. Pereira Lima ◽  
Karen Lima Prata ◽  
Jane Lima dos Santos ◽  
João Monteiro de Pina Neto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Osteogenesis Imperfecta ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Osteoblast Differentiation ◽  
Marrow Mesenchymal Stem Cells

scholarly journals Gene Targeting of Mutant COL1A2 Alleles in Mesenchymal Stem Cells From Individuals With Osteogenesis Imperfecta

2008 ◽  
Vol 16 (1) ◽  
pp. 187-193 ◽  
Author(s):  
Joel R Chamberlain ◽  
David R Deyle ◽  
Ulrike Schwarze ◽  
Peirong Wang ◽  
Roli K Hirata ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenesis Imperfecta ◽  
Gene Targeting

scholarly journals Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0190744 ◽  
Author(s):  
M. M. Pleumeekers ◽  
L. Nimeskern ◽  
J. L. M. Koevoet ◽  
M. Karperien ◽  
K. S. Stok ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Trophic Effects

scholarly journals Upregulating CXCR4 in Human Fetal Mesenchymal Stem Cells Enhances Engraftment and Bone Mechanics in a Mouse Model of Osteogenesis Imperfecta

2011 ◽  
Vol 1 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Gemma N. Jones ◽  
Dafni Moschidou ◽  
Kenneth Lay ◽  
Hassan Abdulrazzak ◽  
Maximilien Vanleene ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Osteogenesis Imperfecta ◽  
Bone Mechanics

scholarly journals 213 TROPHIC EFFECTS OF MESENCHYMAL STEM CELLS INCREASE CHONDROCYTE PROLIFERATION AND MATRIX FORMATION

2011 ◽  
Vol 19 ◽  
pp. S105 ◽  
Author(s):  
L. Wu ◽  
J. Leijten ◽  
N. Georgi ◽  
C.A. van Blitterswijk ◽  
M. Karperien
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Chondrocyte Proliferation ◽  
Trophic Effects

scholarly journals Hypoxic preconditioning potentiates the trophic effects of mesenchymal stem cells on co-cultured human primary hepatocytes

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Harry H. Qin ◽  
Céline Filippi ◽  
Song Sun ◽  
Sharon Lehec ◽  
Anil Dhawan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hypoxic Preconditioning ◽  
Primary Hepatocytes ◽  
Trophic Effects ◽  
Human Primary Hepatocytes

Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice

Blood ◽  
2008 ◽  
Vol 111 (3) ◽  
pp. 1717-1725 ◽  
Author(s):  
Pascale V. Guillot ◽  
Oyebode Abass ◽  
J. H. Duncan Bassett ◽  
Sandra J. Shefelbine ◽  
George Bou-Gharios ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenesis Imperfecta ◽  
Bone Fractures ◽  
First Trimester ◽  
Long Bone ◽  
Structural Protein ◽  
Plate Height ◽  
Multiple Fractures ◽  
Donor Cells

Abstract The inherited skeletal dysplasia osteogenesis imperfecta (OI) results in multiple fractures and is currently treated empirically. We transplanted human first-trimester fetal blood mesenchymal stem cells (MSCs) into homozygous oim mice in utero. This resulted in a two-thirds reduction in long bone fractures (P < .01), with fewer fractures per mouse (median 1, range 0-2 in mice that received transplants vs median 3, range 1-5 in mice that did not receive transplants by 12 weeks, P < .01). Nearly all mice that did not receive transplants had fractures (47 [97.9%] of 48), in contrast to 17 (58.6%) of 29 4- to 12-week-old mice that received transplants (P < .01). Transplantation was associated with increased bone strength (P < .01), thickness (P < .01), and length (P < .01), and normalization/reduction of growth plate height in 4- to 12-week-old oim was reduced in mice that underwent transplantion (P < .001). More donor cells were found in bone tissues compared with other organs (P < .001), with cells clustered in areas of active bone formation and remodeling, and at sites of fracture healing. Donor cells found in the bone expressed osteoblast lineage genes, and produced the extracellular bone structural protein osteopontin. Finally, MSC transplantation decreased bone hydroxyproline content. In conclusion, intrauterine transplantation of fetal MSCs markedly reduced fracture rates and skeletal abnormalities in a mouse model of the intermediate severity type III OI, suggesting a scientific basis for MSC treatment of affected human fetuses.

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