scholarly journals Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Lyduine E. Collij ◽  
Sophie E. Mastenbroek ◽  
Gemma Salvadó ◽  
Alle Meije Wink ◽  
Pieter Jelle Visser ◽  
...  
Keyword(s):  
Memory Decline ◽  
Amyloid Accumulation

scholarly journals Memory decline accompanies subthreshold amyloid accumulation

Neurology ◽  
2018 ◽  
Vol 90 (17) ◽  
pp. e1452-e1460 ◽  
Author(s):  
Susan M. Landau ◽  
Andy Horng ◽  
William J. Jagust ◽  
Keyword(s):  
Executive Function ◽  
Sex Education ◽  
Memory Performance ◽  
Standardized Uptake Value ◽  
Hippocampal Volume ◽  
Older Individuals ◽  
Memory Decline ◽  
Domain Specific ◽  
Amyloid Accumulation ◽  
Amyloid Aβ

ObjectiveExtensive cortical β-amyloid (Aβ positivity) has been linked to cognitive decline, but the clinical significance of elevations in Aβ within the negative range is unknown.MethodsWe examined amyloid and cognitive trajectories (memory, executive function) in 142 cognitively normal older individuals enrolled in the Alzheimer's Disease Neuroimaging Initiative who were Aβ-negative at baseline and who had at least 2 [18F]-florbetapir PET scans over 3.9 ± 1.4 years. We determined whether Aβ accumulation was associated with longitudinal changes in memory or executive function.ResultsAmong baseline-negative individuals, florbetapir slope (mean annual increase 0.002 ± 0.008 standardized uptake value ratio units/y) was not related to age, sex, education, APOE4 status, baseline memory or executive function, temporoparietal glucose metabolism, baseline hippocampal volume, or hippocampal volume change; but it was related to higher baseline cortical florbetapir, indicating that Aβ accumulation was ongoing at baseline in those who accumulated during the study. Over the course of follow-up, 13 individuals converted to florbetapir+ and 14 nearly nonoverlapping individuals converted to mild cognitive impairment or Alzheimer disease. Amyloid accumulation among baseline-negative individuals was associated with poorer longitudinal memory performance (p = 0.019), but it was not associated with changes in executive function. Reducing the sample to individuals with at least 3 timepoints to estimate the florbetapir slope strengthened the relationship further between florbetapir accumulation and memory decline (p = 0.007).ConclusionsMemory decline accompanies Aβ accumulation in otherwise healthy, Aβ-negative older adults. Amyloid increases within the negative range may represent the earliest detectable indication of pathology with domain-specific cognitive consequences.

O4-01-04: Episodic memory decline is associated with cortical amyloid accumulation in healthy community-dwelling, non demented older adults

2011 ◽  
Vol 7 ◽  
pp. S682-S682
Author(s):  
David Darby ◽  
Amy Brodtmann ◽  
Robert Pietrzak ◽  
Michael Woodward ◽  
Victor Villemagne ◽  
...  
Keyword(s):  
Older Adults ◽  
Episodic Memory ◽  
Community Dwelling ◽  
Memory Decline ◽  
Amyloid Accumulation ◽  
Healthy Community

CHOLINERGIC DEFICIT AS A PREDICTOR OF DISEASE PROGRESSION: AMYLOID ACCUMULATION AND EPISODIC MEMORY DECLINE IN A 27-MONTH PRECLINICAL AD STUDY

2017 ◽  
Vol 13 (7) ◽  
pp. P1232-P1233 ◽  
Author(s):  
Peter J. Snyder ◽  
Cláudia Y. Santos ◽  
Christine Getter ◽  
Rachel Schindler ◽  
Brian R. Ott ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Disease Progression ◽  
Memory Decline ◽  
Cholinergic Deficit ◽  
Preclinical Ad ◽  
Amyloid Accumulation

I Rate My Memory Quite Similar at Age 40 and at Age 70

GeroPsych ◽  
2020 ◽  
Vol 33 (4) ◽  
pp. 235-244
Author(s):  
Boo Johansson ◽  
Marcus Praetorius Björk ◽  
Valgeir Thorvaldsson
Keyword(s):  
Change Score ◽  
Subjective Memory ◽  
Memory Decline ◽  
Memory Factor ◽  
Invariance Testing ◽  
Adult Lifespan ◽  
Memory Functioning ◽  
Acceptable Model ◽  
Score Model ◽  
Old Men

Abstract. In 1987, we administered a subjective memory questionnaire to 143 40-year-old men, and 30 years later 67 of them again responded to the same questionnaire at age 70. At the follow-up, we also instructed participants to answer the questionnaire in the same manner as they thought they did at age 40 and to perform a picture recognition and a public event test. We employed confirmatory factor analysis to model a latent subjective memory construct. A single-factor solution provided acceptable model fit to data (χ2(12) = 9.33, p = .68; χ2(12) = 10.48, p = .57) and a decent reliability at both ages for the subjective memory measurements (omega = .82 and .93, respectively). Our longitudinal invariance testing revealed only a partial weak invariance. We also fitted a latent change-score model to the data. As expected, participants on average rated their memory as poorer at age 70 than at 40. Those who reported better overall health and less anxiety reported less memory decline up to age 70. Notably, this was also the case for those who rated memory as worse at age 40. Higher stress and depression at age 70, however, were associated with worse subjective memory already at age 40. The correspondences between memory ratings and tests were low. The correlation between the subjective memory factors at age 40 and 70 was 0.58, while the correlation between the memory factor at age 70 and the retrospective subjective memory factor was 0.87. Our findings suggest that subjective memory is quite consistent, and that we are inclined to preserve the continuity of our own memory functioning over the adult lifespan.

Combined genetic influences on episodic memory decline in older adults without dementia.

2020 ◽  
Vol 34 (6) ◽  
pp. 654-666 ◽  
Author(s):  
Erika J. Laukka ◽  
Ylva Köhncke ◽  
Goran Papenberg ◽  
Laura Fratiglioni ◽  
Lars Bäckman
Keyword(s):  
Older Adults ◽  
Episodic Memory ◽  
Genetic Influences ◽  
Memory Decline

Centella asiatica Protects Against the Toxic Effects of Intracellular beta-amyloid Accumulation

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
N Gray ◽  
J Morré ◽  
J Kelley ◽  
C Maier ◽  
F Stevens ◽  
...  
Keyword(s):  
Centella Asiatica ◽  
Beta Amyloid ◽  
Toxic Effects ◽  
Amyloid Accumulation

Fear of memory decline predicts lower quality of life and increased memory failures in older adults: Preliminary findings from a novel fear-avoidance of memory decline scale.

2020 ◽  
Author(s):  
Francesca Farina ◽  
Marc Patrick Bennett ◽  
James William Griffith ◽  
Bert Lenaert
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Memory Performance ◽  
Fear Avoidance ◽  
Subjective Memory ◽  
Memory Decline ◽  
General Anxiety ◽  
Quality Of Life Scale ◽  
The Impact

Evidence concerning the impact of fear of memory decline on health-related outcomes is limited. To determine the relationship between fear-avoidance of memory decline, quality of life and subjective memory in older adults using a novel scale to measure fear of memory decline. Sixty-seven older adults (59-81 years) completed a 23-item self-report questionnaire designed to capture experiential, cognitive and behavioral components of fear of memory decline, known as the fear and avoidance of memory decline (FAM) scale. Memory performance was assessed using the Wechsler Memory Scale (WMS-IV) and the Memory Failures Scale (MFS). General anxiety was assessed using the Depression, Anxiety and Stress Scales (DASS) and the Geriatric Anxiety Inventory (GAI). Quality of life was assessed using the Older Person’s Quality of Life scale (OPQOL-35). The FAM scale demonstrated good reliability and validity. Three latent factors were observed including: (1) fear-avoidance, (2) problematic beliefs and (3) resilience. After adjusting for age, education, memory performance and general anxiety, higher fear-avoidance predicted lower quality of life (p=.021) and increased memory failures (p=.022). Increased fear of memory decline predicts lower quality of life and subjective memory failures in healthy older adults. Based on these findings, we propose a preliminary fear-avoidance model that explains the development and maintenance of dementia-related functional disability in terms of psychological processes.

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