Preparation and characterization of chitosan microparticles for oral sustained delivery of gliclazide: in vitro/in vivo evaluation

2010 ◽  
Vol 72 (3) ◽  
pp. 235-246 ◽  
Author(s):  
Nahla S. Barakat ◽  
Alanood S. Almurshedi
Keyword(s):  
Sustained Delivery ◽  
In Vivo Evaluation ◽  
Chitosan Microparticles

Synthesis, Characterization and in vivo Evaluation of PEGylated PPI Dendrimer for Safe and Prolonged Delivery of Insulin

2019 ◽  
Vol 9 (3) ◽  
pp. 248-263 ◽  
Author(s):  
Ashish K. Parashar ◽  
Preeti Patel ◽  
Arun K. Gupta ◽  
Neetesh K. Jain ◽  
Balak Das Kurmi
Keyword(s):  
Blood Glucose ◽  
Drug Release ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Albino Rats ◽  
Sustained Delivery ◽  
In Vivo Evaluation ◽  
Hemolytic Toxicity

Background: The present study was aimed at developing and exploring the use of PEGylated Poly (propyleneimine) dendrimers for the delivery of an anti-diabetic drug, insulin. Methods: For this study, 4.0G PPI dendrimer was synthesized by successive Michael addition and exhaustive amidation reactions, using ethylenediamine as the core and acrylonitrile as the propagating agent. Two different activated PEG moieties were employed for PEGylation of PPI dendrimers. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release, hemolytic toxicity and blood glucose level studies of both PEGylated and non- PEGylated dendritic systems were determined and compared. Results: PEGylation of PPI dendrimers caused increased solubilization of insulin in the dendritic framework as well as in PEG layers, reduced drug release and hemolytic toxicity as well as increased therapeutic efficacy with reduced side effects of insulin. These systems were found to be suitable for sustained delivery of insulin by in vitro and blood glucose-level studies in albino rats, without producing any significant hematological disturbances. Conclusion: Thus, surface modification of PPI dendrimers with PEG molecules has been found to be a suitable approach to utilize it as a safe and effective nano-carrier for drug delivery.

Dual-energy CT for the characterization of urinary calculi: In vitro and in vivo evaluation of a low-dose scanning protocol

2009 ◽  
Vol 19 (6) ◽  
pp. 1553-1559 ◽  
Author(s):  
C. Thomas ◽  
O. Patschan ◽  
D. Ketelsen ◽  
I. Tsiflikas ◽  
A. Reimann ◽  
...  
Keyword(s):  
Low Dose ◽  
Urinary Calculi ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
In Vivo Evaluation ◽  
Scanning Protocol

In vitro and in vivo characterization of a novel biocompatible polymer–lipid implant system for the sustained delivery of paclitaxel

2005 ◽  
Vol 104 (1) ◽  
pp. 181-191 ◽  
Author(s):  
Emmanuel A. Ho ◽  
Vessela Vassileva ◽  
Christine Allen ◽  
Micheline Piquette-Miller
Keyword(s):  
Sustained Delivery ◽  
Biocompatible Polymer ◽  
Implant System ◽  
In Vivo Characterization

Liposomal Gels for Site-Specific, Sustained Delivery of Celecoxib: In Vitro and In Vivo Evaluation

2014 ◽  
Vol 75 (4) ◽  
pp. 257-266 ◽  
Author(s):  
Gihan Fetih ◽  
Dina Fathalla ◽  
Mahmoud El-Badry
Keyword(s):  
Sustained Delivery ◽  
In Vivo Evaluation ◽  
Site Specific

Endovascular Shear Strain Elastography for the Detection and Characterization of the Severity of Atherosclerotic Plaques: In Vitro Validation and In Vivo Evaluation

2014 ◽  
Vol 40 (5) ◽  
pp. 890-903 ◽  
Author(s):  
Younes Majdouline ◽  
Jacques Ohayon ◽  
Zahra Keshavarz-Motamed ◽  
Marie-Hélène Roy Cardinal ◽  
Damien Garcia ◽  
...  
Keyword(s):  
Shear Strain ◽  
Atherosclerotic Plaques ◽  
In Vivo Evaluation ◽  
Strain Elastography
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