Fabrication and Characterization of Surface Engineered Rifampicin Loaded Lipid Nanoparticulate Systems for the Potential Treatment of Tuberculosis: An In Vitro and In Vivo Evaluation

2021 ◽  
Vol 110 (5) ◽  
pp. 2221-2232
Author(s):  
Nimitt V. Chokshi ◽  
Shruti Rawal ◽  
Dhruvi Solanki ◽  
Saumitra Gajjar ◽  
Vivek Bora ◽  
...  
Keyword(s):  
Potential Treatment ◽  
In Vivo Evaluation ◽  
Fabrication And Characterization ◽  
Nanoparticulate Systems

Fabrication and characterization of nifedipine loaded β-cyclodextrin nanosponges: An in vitro and in vivo evaluation

2017 ◽  
Vol 41 ◽  
pp. 344-350 ◽  
Author(s):  
Madhuri Shringirishi ◽  
Alok Mahor ◽  
Rishikesh Gupta ◽  
Sunil Kumar Prajapati ◽  
Kuldeep Bansal ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Cyclodextrin Nanosponges ◽  
Fabrication And Characterization

Dual-energy CT for the characterization of urinary calculi: In vitro and in vivo evaluation of a low-dose scanning protocol

2009 ◽  
Vol 19 (6) ◽  
pp. 1553-1559 ◽  
Author(s):  
C. Thomas ◽  
O. Patschan ◽  
D. Ketelsen ◽  
I. Tsiflikas ◽  
A. Reimann ◽  
...  
Keyword(s):  
Low Dose ◽  
Urinary Calculi ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
In Vivo Evaluation ◽  
Scanning Protocol

Development of bozepinib-loaded nanocapsules for nose-to-brain delivery: preclinical evaluation in glioblastoma

Nanomedicine ◽  
2021 ◽  
Author(s):  
Amanda de Fraga Dias ◽  
Danieli Rosane Dallemole ◽  
Franciele Aline Bruinsmann ◽  
Luiz Fernando Lopes Silva ◽  
Olga Cruz-López ◽  
...  
Keyword(s):  
Zeta Potential ◽  
Encapsulation Efficiency ◽  
Brain Delivery ◽  
Particle Sizes ◽  
Potential Treatment ◽  
Preclinical Evaluation ◽  
Glioma Growth

Aim: To develop and characterize bozepinib-loaded lipid-core nanocapsules (BZP-LNC+) as a potential treatment for glioblastoma (GBM). Methods: Characterization of nanocapsules was performed by diameter, polydispersity index, zeta potential, pH and encapsulation efficiency. GBM cell viability, cell cycle and Annexin/PI were evaluated after BZP-LNC+ treatment. Synergism between BZP-LNC+ and temozolomide (TMZ) was performed by CompuSyn software and confirmed in vitro and in vivo. Results: BZP-LNC+ showed adequate particle sizes, positive zeta potential, narrow size distribution and high encapsulation efficiency. BZP-LNC+ reduces GBM growth by inducing apoptosis. BZP-LNC+ and TMZ showed synergistic effect in vitro and reduced the in vivo glioma growth by approximately 81%. Conclusion: The present study provides proof-of-principle insights for the combination of these drugs for GBM treatment.

Endovascular Shear Strain Elastography for the Detection and Characterization of the Severity of Atherosclerotic Plaques: In Vitro Validation and In Vivo Evaluation

2014 ◽  
Vol 40 (5) ◽  
pp. 890-903 ◽  
Author(s):  
Younes Majdouline ◽  
Jacques Ohayon ◽  
Zahra Keshavarz-Motamed ◽  
Marie-Hélène Roy Cardinal ◽  
Damien Garcia ◽  
...  
Keyword(s):  
Shear Strain ◽  
Atherosclerotic Plaques ◽  
In Vivo Evaluation ◽  
Strain Elastography

Spectroscopic Characterization of a Polycaprolactone-Chitosan Electrospun Scaffold Modified with Photocatalytic TiO2 Nanoparticles for Improved Wound Healing: A Complete In Vivo Evaluation

2021 ◽  
Vol 17 (5) ◽  
pp. 889-900
Author(s):  
Cuizhen Sun ◽  
Dianju He ◽  
Yonghua Qi ◽  
Guiqin Zhang ◽  
Qiujin Huang
Keyword(s):  
Wound Healing ◽  
Lattice Structure ◽  
Spectroscopic Characterization ◽  
Electrospun Scaffold ◽  
Zone Of Inhibition ◽  
In Vivo Evaluation ◽  
Electrospinning Technique

In the current study, we hypothesized that the electrospun scaffold chitosan (CS)/polycaprolactone (PCL)/titanium dioxide (TiO2) could be prepared by combining CS, PCL, and TiO2 nanoparticles (TiO2 NPs) using an electrospinning technique for wound dressing applications. The CS/PCL/TiO2 electrospun scaffold was prepared and characterized by UV-Vis, SEM, TEM, FTIR, and XRD analyses. Based on the UV-Vis analysis, the incorporation of CS/PCL on the surface of TiO2 NPs affected their optical properties. Further, CS/PCL and CS/PCL/TiO2 were found to have uniform distribution in fiber diameter with no bead morphology, as confirmed by SEM. The XRD spectrum of the CS/PCL/TiO2 revealed that the TiO2 NPs were adequately mixed with the CS/PCL solution, exhibiting the planes of TiO2 peaks (112), (105), (204), (116), and (301), which aligned well with the lattice structure. The antibacterial activity of CS/PCL/TiO2 against Staphylococcus aureus and Escherichia coli was evaluated using the zone of inhibition method. By testing the cytocompatibility of CS/PCL/TiO2 in vitro, this dressing was found to have a less toxic nature. In addition, In Vivo wound healing studies showed that the dressing prepared with the CS/PCL/TiO2 electrospun scaffold improved wound healing compared to that prepared with CS/PCL alone. The above results strongly support the use of CS/PCL/TiO2 electrospun scaffold as an effective dressing for wound healing.

scholarly journals Characterization of Soy Polysaccharide and Its In Vitro and In Vivo Evaluation for Application in Colon Drug Delivery

2012 ◽  
Vol 13 (3) ◽  
pp. 934-943 ◽  
Author(s):  
B. M. Ursekar ◽  
P. S. Soni ◽  
Abhijit A. Date ◽  
M. S. Nagarsenker
Keyword(s):  
Drug Delivery ◽  
In Vivo Evaluation ◽  
Colon Drug Delivery

scholarly journals In vitro characterization of SynthoPlate™ (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice

2017 ◽  
Vol 15 (2) ◽  
pp. 375-387 ◽  
Author(s):  
M. Shukla ◽  
U. D. S. Sekhon ◽  
V. Betapudi ◽  
W. Li ◽  
D. A. Hickman ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
In Vitro Characterization
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