Comprehensive characterization of the peroxisome proliferator activated receptor‐δ agonist GW501516 for horse doping control analysis

2021 ◽  
Author(s):  
Stéphane Trevisiol ◽  
Yves Moulard ◽  
Vivian Delcourt ◽  
Murielle Jaubert ◽  
Sophie Boyer ◽  
...  
Keyword(s):  
Doping Control ◽  
Peroxisome Proliferator ◽  
Control Analysis ◽  
Peroxisome Proliferator Activated Receptor ◽  
Comprehensive Characterization

scholarly journals PRIC295, a Nuclear Receptor Coactivator, Identified from PPAR-Interacting Cofactor Complex

PPAR Research ◽  
2010 ◽  
Vol 2010 ◽  
pp. 1-16 ◽  
Author(s):  
Sean R. Pyper ◽  
Navin Viswakarma ◽  
Yuzhi Jia ◽  
Yi-Jun Zhu ◽  
Joseph D. Fondell ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Target Genes ◽  
Peroxisome Proliferator ◽  
Dependent Manner ◽  
Peroxisome Proliferator Activated Receptor ◽  
Nuclear Receptor Coactivator ◽  
Evolutionarily Conserved

The peroxisome proliferator-activated receptor- (PPAR) plays a key role in lipid metabolism and energy combustion. Chronic activation of PPAR in rodents leads to the development of hepatocellular carcinomas. The ability of PPAR to induce expression of its target genes depends on Mediator, an evolutionarily conserved complex of cofactors and, in particular, the subunit 1 (Med1) of this complex. Here, we report the identification and characterization of PPAR-interacting cofactor (PRIC)-295 (PRIC295), a novel coactivator protein, and show that it interacts with the Med1 and Med24 subunits of the Mediator complex. PRIC295 contains 10 LXXLL signature motifs that facilitate nuclear receptor binding and interacts with PPAR and five other members of the nuclear receptor superfamily in a ligand-dependent manner. PRIC295 enhances the transactivation function of PPAR, PPAR, and ER. These data demonstrate that PRIC295 interacts with nuclear receptors such as PPAR and functions as a transcription coactivator underin vitroconditions and may play an important role in mediating the effectsin vivoas a member of the PRIC complex with Med1 and Med24.

scholarly journals Characterization of Novel Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) Isoform in Human Liver

2011 ◽  
Vol 286 (50) ◽  
pp. 42923-42936 ◽  
Author(s):  
Thomas K. Felder ◽  
Selma M. Soyal ◽  
Hannes Oberkofler ◽  
Penelope Hahne ◽  
Simon Auer ◽  
...  
Keyword(s):  
Human Liver ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor

Cloning and Characterization of Goose PPARγ Gene Comparison with other Vertebrates

2011 ◽  
Vol 343-344 ◽  
pp. 820-825
Author(s):  
H.L. Wu ◽  
Fan Li Kong ◽  
M.H. Qiu ◽  
Bo Zhou ◽  
J. Luo ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Transcriptional Control ◽  
Peroxisome Proliferator ◽  
Coding Region ◽  
Peroxisome Proliferator Activated Receptor ◽  
Gene Comparison ◽  
Pparγ Gene ◽  
Molecular Nature

The peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor involved in the transcriptional control of energy, lipid, and glucose homeostasis. In this study, we cloned goose PPARγ gene. The amplified fragment contains coding region sequence with 1731 nucleotides, which putatively codes for 453 amino acids (AA). The homology of nucleotide sequences is from 81.4% to 99.9% among the twelve vertebrates, while the similarity of amino acid sequence ranged from 91.8% to 99.8%. Results showed that the PPARγ gene is conservative among different species. This work constructed the basis for further research on the molecular nature and genetic markers of PPARγ for metabolism traits in goose.

scholarly journals Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene

2000 ◽  
Vol 275 (37) ◽  
pp. 28488-28493 ◽  
Author(s):  
Sander Kersten ◽  
Stéphane Mandard ◽  
Nguan Soon Tan ◽  
Pascal Escher ◽  
Daniel Metzger ◽  
...  
Keyword(s):  
Target Gene ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor
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