In vitro metabolic studies of novel selective androgen receptor modulators and their use for doping control analysis

2021 ◽  
Author(s):  
Katarzyna Kowalczyk ◽  
Julio César Torres‐Elguera ◽  
Anna Jarek ◽  
Anna Konopka ◽  
Dorota Kwiatkowska ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Doping Control ◽  
Control Analysis ◽  
Metabolic Studies ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Identification of equine in vitro metabolites of seven non‐steroidal selective androgen receptor modulators for doping control purposes

2021 ◽  
Author(s):  
Charlotte Cutler ◽  
Marjaana Viljanto ◽  
Polly Taylor ◽  
Pamela Hincks ◽  
Simon Biddle ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Doping Control ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

scholarly journals Validation of a GC/MS method for the detection of two quinolinone-derived selective androgen receptor modulators in doping control analysis

2010 ◽  
Vol 400 (1) ◽  
pp. 137-144 ◽  
Author(s):  
E. Gerace ◽  
A. Salomone ◽  
F. Fasano ◽  
R. Costa ◽  
D. Boschi ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Doping Control ◽  
Control Analysis ◽  
In Doping ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes

2015 ◽  
Vol 7 (8) ◽  
pp. 673-683 ◽  
Author(s):  
Annelie Hansson ◽  
Heather Knych ◽  
Scott Stanley ◽  
Mario Thevis ◽  
Ulf Bondesson ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Urinary Metabolites ◽  
Doping Control ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Screening for metabolically stable aryl-propionamide-derived selective androgen receptor modulators for doping control purposes

2006 ◽  
Vol 20 (5) ◽  
pp. 870-876 ◽  
Author(s):  
Mario Thevis ◽  
Matthias Kamber ◽  
Wilhelm Schänzer
Keyword(s):  
Androgen Receptor ◽  
Doping Control ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Characterization of In Vitro Synthesized Equine Metabolites of the Selective Androgen Receptor Modulators S24 and S4

2012 ◽  
Vol 32 (9) ◽  
pp. 562-568 ◽  
Author(s):  
Oliver Krug ◽  
Andreas Thomas ◽  
Simon Beuck ◽  
Ina Schenk ◽  
Marc Machnik ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Characterization of in vitro generated metabolites of the selective androgen receptor modulators S-22 and S-23 and in vivo comparison to post-administration canine urine specimens

2010 ◽  
Vol 2 (11-12) ◽  
pp. 589-598 ◽  
Author(s):  
Mario Thevis ◽  
Enrico Gerace ◽  
Andreas Thomas ◽  
Simon Beuck ◽  
Hans Geyer ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators ◽  
Urine Specimens

scholarly journals Synthesis of Aryl Propionamide Scaffold Containing a Pentafluorosulfanyl Moiety as SARMs

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4227
Author(s):  
Shao ◽  
Zhou ◽  
Yang ◽  
Wang ◽  
Lu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Androgen Receptor ◽  
Medicinal Chemistry ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

The pentafluorosulfane (SF5) group, as a more electronegative bioisostere than the trifluoromethyl (CF3) group, has been gaining greater attention and increasingly reported usage in medicinal chemistry. Ostarine is the selective androgen receptor modulators (SARMs) containing a CF3 group in clinical trial III. In this study, 21 ostarine derivatives for replacing the CF3 group with SF5 substituents were synthesized. Some SF5-derivatives showed androgen receptor (AR) agonistic activities in vitro. The results pointed to the potential of using this scaffold to develop new AR agonists.

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