Identification of equine in vitro metabolites of seven non‐steroidal selective androgen receptor modulators for doping control purposes

2021 ◽  
Author(s):  
Charlotte Cutler ◽  
Marjaana Viljanto ◽  
Polly Taylor ◽  
Pamela Hincks ◽  
Simon Biddle ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Doping Control ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

In vitro metabolic studies of novel selective androgen receptor modulators and their use for doping control analysis

2021 ◽  
Author(s):  
Katarzyna Kowalczyk ◽  
Julio César Torres‐Elguera ◽  
Anna Jarek ◽  
Anna Konopka ◽  
Dorota Kwiatkowska ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Doping Control ◽  
Control Analysis ◽  
Metabolic Studies ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes

2015 ◽  
Vol 7 (8) ◽  
pp. 673-683 ◽  
Author(s):  
Annelie Hansson ◽  
Heather Knych ◽  
Scott Stanley ◽  
Mario Thevis ◽  
Ulf Bondesson ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Urinary Metabolites ◽  
Doping Control ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Characterization of In Vitro Synthesized Equine Metabolites of the Selective Androgen Receptor Modulators S24 and S4

2012 ◽  
Vol 32 (9) ◽  
pp. 562-568 ◽  
Author(s):  
Oliver Krug ◽  
Andreas Thomas ◽  
Simon Beuck ◽  
Ina Schenk ◽  
Marc Machnik ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

scholarly journals Synthesis of Aryl Propionamide Scaffold Containing a Pentafluorosulfanyl Moiety as SARMs

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4227
Author(s):  
Shao ◽  
Zhou ◽  
Yang ◽  
Wang ◽  
Lu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Androgen Receptor ◽  
Medicinal Chemistry ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

The pentafluorosulfane (SF5) group, as a more electronegative bioisostere than the trifluoromethyl (CF3) group, has been gaining greater attention and increasingly reported usage in medicinal chemistry. Ostarine is the selective androgen receptor modulators (SARMs) containing a CF3 group in clinical trial III. In this study, 21 ostarine derivatives for replacing the CF3 group with SF5 substituents were synthesized. Some SF5-derivatives showed androgen receptor (AR) agonistic activities in vitro. The results pointed to the potential of using this scaffold to develop new AR agonists.

scholarly journals Novel Protective Group Synthesis of Androgen Receptor Modulators with Steroidal and Nonsteroidal Scaffolds

2019 ◽  
Author(s):  
Matthias Grill ◽  
Melanie Patt ◽  
Alex Odermatt
Keyword(s):  
Androgen Receptor ◽  
Molecular Mechanisms ◽  
Anabolic Androgenic Steroids ◽  
Protective Group ◽  
Mood Changes ◽  
Selective Androgen Receptor Modulators ◽  
And Performance ◽  
Androgenic Steroids ◽  
Receptor Modulators

Anabolic androgenic steroids (AAS) are frequently used either clinically, by athletes, or for body shaping due to their muscle building and performance enhancing properties. AAS misuse is associated with cardiovascular diseases, mood changes and endocrine issues. Despite the recognition of the severe adverse effects of AAS misuse, the underlying molecular mechanisms are insufficiently understood. Selective androgen receptor modulators (SARMs) are supposed to diminish the adverse androgenic AAS effects while maximizing anabolic effects. In order to obtain androgen receptor modulating compounds of high purity for mechanistic in vitro investigations, this study summarizes protocols of optimized chemical synthesis for five AAS and two SARMs.

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