Characterization of in vitro generated metabolites of the selective androgen receptor modulators S-22 and S-23 and in vivo comparison to post-administration canine urine specimens

2010 ◽  
Vol 2 (11-12) ◽  
pp. 589-598 ◽  
Author(s):  
Mario Thevis ◽  
Enrico Gerace ◽  
Andreas Thomas ◽  
Simon Beuck ◽  
Hans Geyer ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators ◽  
Urine Specimens

Characterization of In Vitro Synthesized Equine Metabolites of the Selective Androgen Receptor Modulators S24 and S4

2012 ◽  
Vol 32 (9) ◽  
pp. 562-568 ◽  
Author(s):  
Oliver Krug ◽  
Andreas Thomas ◽  
Simon Beuck ◽  
Ina Schenk ◽  
Marc Machnik ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

In vivo characterization of estrogen receptor modulators with reduced genomic versus nongenomic activity in vitro

2008 ◽  
Vol 111 (1-2) ◽  
pp. 95-100 ◽  
Author(s):  
Christiane Otto ◽  
Iris Fuchs ◽  
Helga Altmann ◽  
Mario Klewer ◽  
Gilda Schwarz ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Modulators ◽  
In Vivo Characterization ◽  
Receptor Modulators

Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes

2015 ◽  
Vol 7 (8) ◽  
pp. 673-683 ◽  
Author(s):  
Annelie Hansson ◽  
Heather Knych ◽  
Scott Stanley ◽  
Mario Thevis ◽  
Ulf Bondesson ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Urinary Metabolites ◽  
Doping Control ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Design, Synthesis, and in Vivo SAR of a Novel Series of Pyrazolines as Potent Selective Androgen Receptor Modulators

2007 ◽  
Vol 50 (16) ◽  
pp. 3857-3869 ◽  
Author(s):  
Xuqing Zhang ◽  
Xiaojie Li ◽  
George F. Allan ◽  
Tifanie Sbriscia ◽  
Olivia Linton ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Design Synthesis ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Development of an Analytical Methodology for the Qualitative and Quantitative Characterization of Capsules with Andarine, in Order to Use them to Investigate the Pharmacotoxicological Profile of the Substance

2019 ◽  
Vol 70 (8) ◽  
pp. 2759-2763
Author(s):  
Amalia Miklos ◽  
Amelia Tero Vescan ◽  
Lenard Farczadi ◽  
Silvia Imre ◽  
Camil Eugen Vari ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
The Internet ◽  
Mass Content ◽  
European Pharmacopoeia ◽  
Quantitative Characterization ◽  
Analytical Methodology ◽  
Qualitative And Quantitative ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Andarine is one of the most commonly used doping substance between selective androgen receptor modulators (SARMs). The purpose of our study is to characterize qualitatively and quantitatively andarine capsules purchased legally via the Internet through a rapid and precise UHPLC method and the uniformity of mass, content and dissolution assays were determined following the methodology of the European Pharmacopoeia 8th Ed. Regarding the uniformity of mass, the capsules are within the permissible limits, but regarding the active substance content, an average of 4.99 mg of andarine/capsule was obtained (with an RSD of 5.41%) from the 25 mg/capsule declared by the manufacturer.

In vitro metabolic studies of novel selective androgen receptor modulators and their use for doping control analysis

2021 ◽  
Author(s):  
Katarzyna Kowalczyk ◽  
Julio César Torres‐Elguera ◽  
Anna Jarek ◽  
Anna Konopka ◽  
Dorota Kwiatkowska ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Doping Control ◽  
Control Analysis ◽  
Metabolic Studies ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators
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