Cocaine abuse out of competition: Occasional or chronic user in sport—Case report

2021 ◽  
Author(s):  
Dorota Kwiatkowska ◽  
Ruta Banyte ◽  
Krzysztof Grucza ◽  
Aleksandra Drapała ◽  
Mariola Wicka

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Anett Illés ◽  
Péter Balicza ◽  
Viktor Molnár ◽  
Renáta Bencsik ◽  
István Szilvási ◽  
...  

Abstract Background Parkinsonism is a complex multifactorial neurodegenerative disorder, in which genetic and environmental risk factors may both play a role. Among environmental risk factors cocaine was earlier ambiguously linked to Parkinsonism. Former single case reports described Parkinsonism in chronic cocaine users, but an epidemiological study did not confirm an increased risk of Parkinson’s disease. Here we report a patient, who developed Parkinsonism in young age after chronic cocaine use, in whom a homozygous LRRK2 risk variant was also detected. Case presentation The patient was investigated because of hand tremor, which started after a 1.5-year period of cocaine abuse. Neurological examination suggested Parkinsonism, and asymmetrical pathology was confirmed by the dopamine transporter imaging study. The genetic investigations revealed a homozygous risk allele in the LRRK2 gene. After a period of cocaine abstinence, the patient’s symptoms spontaneously regressed, and the dopamine transporter imaging also returned to near-normal. Conclusions This case report suggests that cocaine abuse indeed might be linked to secondary Parkinsonism and serves as an example of a potential gene-environmental interaction between the detected LRRK2 risk variant and cocaine abuse. The reversible nature of the DaTscan pathology is a unique feature of this case, and needs further evaluation, whether this is incidental or can be a feature of cocaine related Parkinsonism.



2013 ◽  
Vol 6 (1) ◽  
pp. 536 ◽  
Author(s):  
Chad J Cooper ◽  
Sarmad Said ◽  
Haider Alkhateeb ◽  
Emmanuel Rodriguez ◽  
Remi Trien ◽  
...  


Epilepsia ◽  
1991 ◽  
Vol 32 (6) ◽  
pp. 890-894 ◽  
Author(s):  
Anil Dhuna ◽  
Alvaro Pascual-Leone ◽  
Frederick Langendorf
Keyword(s):  


2018 ◽  
Vol 29 (3) ◽  
pp. NP5-NP8 ◽  
Author(s):  
Evdoxia-Maria A Karasavvidou ◽  
Georgios P Athanasopoulos ◽  
Anastasios G Konstas ◽  
Eleni A Tsirampidou ◽  
Paris G Tranos

Introduction: The purpose of this report is to describe a case of Valsalva retinopathy in an intranasal cocaine user. Case report: A 49-year-old male presented with a history of sudden loss of vision and inferior visual field defect in his left eye. Clinical evaluation of the affected eye showed best corrected visual acuity of 20/25 and fundus examination revealed a preretinal hemorrhage superior to the disk with multiple intraretinal hemorrhages in and around the posterior pole. On further questioning, the patient revealed intranasal cocaine use the day before the onset of his visual symptoms. Blood tests were requested to exclude blood dyscrasias or predisposition to vascular occlusive disorders and no further treatment measures were taken. The patient was reviewed a month later when his hemorrhages had completely resolved and his visual acuity had improved to 20/20. His blood results were within normal limits. Conclusion: Although never been reported before, Valsalva retinopathy can be associated with intranasal cocaine abuse and should be considered in the differential diagnosis of visual reduction in such population.



2020 ◽  
pp. 1-2
Author(s):  
Amin N A Soofi ◽  
◽  
Ola Abdelhadi ◽  
Abdelhadi Abdelhadi ◽  
◽  
...  

Congenital Acromial or Shoulder dimples are cutaneous depressions overlying the acromial process of the scapula. They are usually bilateral and symmetrical. Isolated biacromial dimples are usually benign and warrant no further investigations. Family history in an autosomal dominant pattern, as in our case, is frequently obtainable but the majority of isolated bilateral shoulder dimples are sporadic. There are few reports of syndromic associations as well as two cases of associated maternal cocaine abuse. Our case is a term female neonate who was noted on routine new-born check to have bilateral symmetrical shoulder dimples. She was otherwise healthy, had normal range of shoulder movements and was not dysmorphic. On further assessment it transpired the father has the same bilateral shoulder dimples but was not aware of their existence. No further investigations were carried out. This case add to the few reported cases of Biacromial Dimples with autosomal pattern of inheritance in an otherwise normal baby



2007 ◽  
Vol 107 (6) ◽  
pp. 690-692
Author(s):  
C. de Magnée ◽  
P. Feron ◽  
A. Mehdi
Keyword(s):  


2002 ◽  
Vol 6 (4) ◽  
pp. 217-219 ◽  
Author(s):  
I.A Liappas ◽  
P.N Malitas ◽  
N.P Dimopoulos ◽  
O.E Gitsa ◽  
A.I Liappas ◽  
...  
Keyword(s):  


2016 ◽  
Vol 61 (6) ◽  
pp. 1681-1685 ◽  
Author(s):  
Erwan Le Garff ◽  
Gilles Tournel ◽  
Coralie Becquart ◽  
Olivier Cottencin ◽  
Nicolas Dupin ◽  
...  
Keyword(s):  




2002 ◽  
Vol 127 (6) ◽  
pp. 572-574 ◽  
Author(s):  
Carlos Ayala ◽  
Lynnette Watkins ◽  
Daniel G. Deschler


Sign in / Sign up

Export Citation Format

Share Document