Bone quality assessed by trabecular bone score in severe anorexia nervosa: A brief report

ObjectiveIn primary hyperparathyroidism (PHPT), vertebral fractures (VFx) occur regardless of bone mineral density (BMD) and may depend on decreased bone quality. Trabecular bone score (TBS) is a texture measurement acquired during a spinal dual-energy X-ray absorptiometry (DXA). Recently, TBS has been proposed as an index of bone micro-architecture.DesignWe studied 92 PHPT patients (74 females, age 62.1±9.7 years) and 98 control subjects. In all patients at baseline, in 20 surgically treated patients and in 10 conservatively treated patients after 24 months, TBS, spinal (lumbar spine (LS)) and femoral (total hip (TH) and femoral neck (FN)) BMD were assessed by DXA and VFx by spinal radiograph.ResultsPHPT patients had lower TBS (−2.39±1.8) and higher VFx prevalence (43.5%) than controls (−0.98±1.07 and 8.2% respectively, bothP<0.0001). TBS was associated with VFx (odds ratio 1.4, 95% CI 1.1–1.9,P=0.02), regardless of LS-BMD, age, BMI and gender, and showed a better compromise between sensitivity (75%) and specificity (61.5%) for detecting VFx than LS-BMD, TH-BMD and FN-BMD (31 and 75%, 72 and 44.2%, and 64 and 65% respectively). In surgically treated patients, TBS, LS-BMD, TH-BMD and FN-BMD increased (+47±44.8,+29.2±34.1,+49.4±48.7 and +30.2±39.3% respectively, allP<0.0001). Among patients treated conservatively, TBS decreased significantly in those (n=3) with incident VFx (−1.3±0.3) compared with those without (−0.01±0.9,P=0.048), while BMD changes were not statistically different (LS 0.3±1.2 vs −0.8±0.9 respectively,P=0.19; TH 0.4±0.8 vs −0.8±1.4 respectively,P=0.13 and FN 0.4±0.9 vs −0.8±1.4 respectively,P=0.14).ConclusionsIn PHPT, bone quality, as measured by TBS, is reduced and associated with VFx and improves after surgery.

Download Full-text

Bone quality, as measured by trabecular bone score (TBS), in patients with primary hyperparathyroidism

Endocrine Abstracts ◽

10.1530/endoabs.32.p74 ◽

2013 ◽

Author(s):

Cristina Eller-Vainicher ◽

Marcello Filopanti ◽

Serena Palmieri ◽

Fabio Massimo Ulivieri ◽

Valentina Morelli ◽

...

Keyword(s):

Primary Hyperparathyroidism ◽

Trabecular Bone ◽

Bone Quality ◽

Trabecular Bone Score

Download Full-text

Similarities and differences between bone quality parameters, trabecular bone score and femur geometry

PLoS ONE ◽

10.1371/journal.pone.0260924 ◽

2022 ◽

Vol 17 (1) ◽

pp. e0260924

Author(s):

Kyong Young Kim ◽

Kyoung Min Kim

Keyword(s):

Trabecular Bone ◽

Cortical Bone ◽

Bone Quality ◽

Cortical Thickness ◽

Trabecular Bone Score ◽

Quality Parameters ◽

Mineral Density ◽

Men And Women ◽

Similarities And Differences ◽

Femur Geometry

Bone quality is a critical factor that, along with bone quantity, determines bone strength. Image-based parameters are used for assessing bone quality non-invasively. The trabecular bone score (TBS) is used to assess quality of trabecular bone and femur geometry for cortical bone. Little is known about the associations between these two bone quality parameters and whether they show differences in the relationships with age and body mass index (BMI). We investigated the associations between the trabecular bone score (TBS) and femur cortical geometry. Areal bone mineral density (BMD) was assessed using dual energy X-ray absorptiometry (DXA) and the TBS was assessed using iNsight software and, femur geometry using APEX (Hologic). A total of 452 men and 517 women aged 50 years and older with no medical history of a condition affecting bone metabolism were included. Z-scores for TBS and cortical thickness were calculated using the age-specific mean and SD for each parameter. A ‘discrepancy group’ was defined as patients whose absolute Z-score difference between TBS and cortical thickness was > 1 point. TBS and cortical thickness correlated negatively with age both in men and women, but the associations were stronger in women. Regarding the associations with BMI, TBS provided significant negative correlation with BMI in the range of BMI > 25 kg/m2. By contrast, cortical thickness correlated positively with BMI for all BMI ranges. These bone quality-related parameters, TBS and cortical thickness, significantly correlated, but discordance between these two parameters was observed in about one-third of the men and women (32.7% and 33.4%, respectively). Conclusively, image-based bone quality parameters for trabecular and cortical bone exhibit both similarities and differences in terms of their associations with age and BMI. These different profiles in TBS and FN cortical thickness might results in different risk profiles for the vertebral fractures or hip fractures in a certain percentage of people.

Download Full-text

Evaluation of bone quality in acromegaly and thyrotoxicosis using trabecular bone score

Endocrine Abstracts ◽

10.1530/endoabs.63.p109 ◽

2019 ◽

Author(s):

Madalina Sorohan ◽

Roxana Dusceac ◽

Bogdan Sorohan ◽

Catalina Poiana

Keyword(s):

Trabecular Bone ◽

Bone Quality ◽

Trabecular Bone Score

Download Full-text

Low trabecular bone score in adolescent female inpatients with anorexia nervosa

Clinical Nutrition ◽

10.1016/j.clnu.2018.04.013 ◽

2019 ◽

Vol 38 (3) ◽

pp. 1166-1170 ◽

Cited By ~ 4

Author(s):

Yael Levy-Shraga ◽

Liana Tripto-Shkolnik ◽

Dana David ◽

Iris Vered ◽

Daniel Stein ◽

...

Keyword(s):

Anorexia Nervosa ◽

Trabecular Bone ◽

Trabecular Bone Score ◽

Adolescent Female

Download Full-text

Bone density, microarchitecture and tissue quality after 1 year of treatment with dolutegravir/abacavir/lamivudine

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/dkaa254 ◽

2020 ◽

Vol 75 (10) ◽

pp. 2998-3003

Author(s):

Jade Soldado-Folgado ◽

Elisabeth Lerma-Chippirraz ◽

Itziar Arrieta-Aldea ◽

Daniel Bujosa ◽

Natalia García-Giralt ◽

...

Keyword(s):

Trabecular Bone ◽

Bone Tissue ◽

Bone Quality ◽

Bone Health ◽

Trabecular Bone Score ◽

Bone Microarchitecture ◽

Tissue Quality ◽

Art Initiation ◽

The Impact ◽

Health Parameters

Abstract Background Bone mineral density (BMD) decreases with ART initiation with a tenofovir disoproxil fumarate-containing regimen, although bone tissue quality increases. The impact of dolutegravir (DTG)/abacavir (ABC)/lamivudine (3TC)-based ART initiation on bone health parameters is not clear. Objectives To study the impact of DTG/ABC/3TC-based therapy on bone health parameters in ART-naive individuals with HIV after 48 weeks of treatment. Methods An observational, prospective and analytical study of treatment-naive patients with HIV undergoing a DTG/ABC/3TC-based regimen at 48 week follow-up. Changes in bone strength parameters (BMD, bone microarchitecture and bone tissue quality) were assessed with non-parametric methods. Results Sixteen HIV-infected ART-naive patients starting DTG/ABC/3TC were included. BMD in the lumbar spine showed a significant decrease of −2.25% (P = 0.007) and −4.1% in the femoral neck (P = 0.007). Bone microarchitecture, as measured by trabecular bone score, also decreased significantly by −2.5% (P = 0.03). In contrast, bone quality [bone material strength index (BMi)], as measured by microindentation, significantly increased with respect to baseline after 48 weeks of treatment, showing better bone properties of +6.53% (P < 0.001). No significant changes were found in bone turnover markers. In addition, a positive significant correlation between the CD4/CD8 cell count ratio at baseline and changes in BMSi after 48 weeks of treatment was observed (Spearman’s rho = 0.4974; P = 0.04). Conclusions After a 48 week treatment with DTG/ABC/3TC-based ART, BMD and trabecular bone score decreased while bone tissue quality, as measured by microindentation, improved significantly. The state of the immune system at ART initiation is related to bone quality recovery. An overarching approach to assess bone toxicity in ART-treated patients is needed.

Download Full-text