In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild-type p53

1993 ◽  
Vol 23 (9) ◽  
pp. 2072-2077 ◽  
Author(s):  
Jos G. A. Houbiers ◽  
Hans W. Nijman ◽  
Sjoerd H. Van Der Burg ◽  
Jan Wouter Drijfhout ◽  
Peter Kenemans ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Wild Type ◽  
Wild Type P53 ◽  
Lymphocyte Responses ◽  
In Vitro Induction

scholarly journals Sendai virus-specific, H-2-restricted cytotoxic T lymphocyte responses of nude mice grafted with allogeneic or semi-allogeneic thymus glands.

1980 ◽  
Vol 152 (6) ◽  
pp. 1805-1810 ◽  
Author(s):  
J P Lake ◽  
M E Andrew ◽  
C W Pierce ◽  
T J Braciale
Keyword(s):  
T Lymphocyte ◽  
Nude Mice ◽  
Sendai Virus ◽  
Cytotoxic T Lymphocyte ◽  
Target Cells ◽  
Self Recognition ◽  
Parental Haplotype ◽  
Lymphocyte Responses ◽  
Ctl Responses

The in vitro secondary cytotoxic T lymphocyte (CTL) response to Sendai virus-treated stimulator cells by primed spleen cells from thymus gland-grafted nude mice was examined. BALB/c (H-2d) nude mice grafted with allogeneic C57BL/10 (H-2b) thymus glands developed CTL responses directed exclusively to Sendai virus-infected H-2d target cells. (C57BL/6 X BALB/c)F1 nude mice grafted with thymus glands of either parent developed CTL responses preferentially against infected target cells expressing the MHC antigens present in the parental thymus graft, but also had detectable activity for infected target cells of the parental haplotype not expressed in the thymus. These results provide evidence against the concept that self recognition by MHC-restricted CTL is directed exclusively by the MCH type of the thymus.

In vitro effects of malathion and O,O,S-trimethyl phosphorothioate on cytotoxic T-lymphocyte responses

1985 ◽  
Vol 24 (2) ◽  
pp. 260-266 ◽  
Author(s):  
Kathleen E. Rodgers ◽  
Marcia H. Grayson ◽  
Toshiko Imamura ◽  
Bruce H. Devens
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
In Vitro Effects ◽  
Lymphocyte Responses

scholarly journals Accelerated tumor growth in mice deficient in DNAM-1 receptor

2008 ◽  
Vol 205 (13) ◽  
pp. 2959-2964 ◽  
Author(s):  
Akiko Iguchi-Manaka ◽  
Hirayasu Kai ◽  
Yumi Yamashita ◽  
Kai Shibata ◽  
Satoko Tahara-Hanaoka ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Nk Cell ◽  
Cytotoxic T Lymphocyte ◽  
Immune Surveillance ◽  
Tumor Development ◽  
Wild Type ◽  
Human And Mouse ◽  
Deficient Mice

Since the identification of ligands for human and mouse DNAM-1, emerging evidence has suggested that DNAM-1 plays an important role in the T cell– and natural killer (NK) cell–mediated recognition and lysis of tumor cells. However, it remains undetermined whether DNAM-1 is involved in tumor immune surveillance in vivo. We addressed this question by using DNAM-1–deficient mice. DNAM-1–deficient cytotoxic T lymphocyte (CTL) and NK cells showed significantly less cytotoxic activity against DNAM-1 ligand-expressing tumors in vitro than wild-type (WT) cells. The methylcholanthrene (MCA)-induced fibrosarcoma cell line Meth A expressed the DNAM-1 ligand CD155, and DNAM-1–deficient mice showed increased tumor development and mortality after transplantation of Meth A cells. Moreover, the DNAM-1–deficient mice developed significantly more DNAM-1 ligand-expressing fibrosarcoma and papilloma cells in response to the chemical carcinogens MCA and 7,12-dimethylbenz[a]anthracene (DMBA), respectively, than did WT mice. These results indicate that DNAM-1 plays an important role in immune surveillance of tumor development.

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