CD4-dependent and -independent association of protein tyrosine kinases to the T cell receptor/CD3 complex of CD4+ mouse T lymphocytes

1996 ◽  
Vol 26 (6) ◽  
pp. 1228-1234 ◽  
Author(s):  
Gabriel Criado ◽  
Maria José Feito ◽  
José M. Rojo
2014 ◽  
Vol 6 (12) ◽  
pp. 1183-1195
Author(s):  
Barbara Szomolay ◽  
Hugo A. van den Berg

We extend the kinetic proofreading model of TCR triggering to show how phosphatase activity can modulate the TCR's sensitivity and specificity.


1995 ◽  
Vol 182 (5) ◽  
pp. 1585-1590 ◽  
Author(s):  
N S van Oers ◽  
H von Boehmer ◽  
A Weiss

The pre-T cell receptor (TCR) complex regulates early T cell development and consists of a heterodimer of the TCR-beta subunit in association with the pre-TCR-alpha chain. Notably, in contrast to alpha/beta-expressing T cells, several studies suggested that the TCR-zeta chain is not stably associated with this pre-TCR complex. To examine the proximal signaling processes mediated by the pre-TCR complex and the role of the TCR-zeta chain in these processes, we stimulated pre-TCR-expressing cells and analyzed the interactions of the TCR/CD3 invariant chains with the Syk/ZAP-70 family of protein tyrosine kinases. Stimulation of the pre-TCR complex led to the tyrosine phosphorylation of the CD3 epsilon and TCR-zeta chains, as well as the phosphorylation and association of ZAP-70 and Syk with phosphorylated CD3 epsilon and TCR-zeta. These results demonstrate that the pre-TCR complex is functionally coupled to the TCR-zeta subunit and to the ZAP-70 and Syk protein tyrosine kinases.


1999 ◽  
Vol 274 (3) ◽  
pp. 1407-1414 ◽  
Author(s):  
Satoshi Motoya ◽  
Koichi Kitamura ◽  
Akio Matsuda ◽  
Abby L. Maizel ◽  
Hiroyuki Yamamoto ◽  
...  

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