Platinum Anticancer Coordination Compounds: Study of DNA Binding Inspires New Drug Design

The development of a few worldwide routinely used Pt(II) coordination compounds is described from a mechanistic point of view and related to the molecular aspects of Pt-DNA binding. Mechanistic knowledge developed from these studies is applied nowadays for the design and synthesis of new bifunctional and trifunctional compounds, aimed for use as improved anticancer drugs.

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Minimizing the risk of chemically reactive metabolite formation of new drug candidates: implications for preclinical drug design

Drug Discovery Today ◽

10.1016/j.drudis.2016.11.018 ◽

2017 ◽

Vol 22 (5) ◽

pp. 751-756 ◽

Cited By ~ 18

Author(s):

Andreas Brink ◽

Axel Pähler ◽

Christoph Funk ◽

Franz Schuler ◽

Simone Schadt

Keyword(s):

Drug Design ◽

Reactive Metabolite ◽

Metabolite Formation ◽

Drug Candidates ◽

New Drug

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Bio-sensitive activities of coordination compounds containing 1,10-phenanthroline as co-ligand: Synthesis, structural elucidation and DNA binding properties of metal(II) complexes

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ◽

10.1016/j.saa.2014.04.114 ◽

2014 ◽

Vol 131 ◽

pp. 355-364 ◽

Cited By ~ 19

Author(s):

Natarajan Raman ◽

Rajkumar Mahalakshmi ◽

Liviu Mitu

Keyword(s):

Dna Binding ◽

Coordination Compounds ◽

Structural Elucidation ◽

Binding Properties ◽

Ligand Synthesis ◽

Dna Binding Properties

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New Drug Design for IgE Mediated Allergic Inflammation

Ensho ◽

10.2492/jsir1981.8.5 ◽

1988 ◽

Vol 8 (1) ◽

pp. 5-6

Author(s):

Nobuhiko Katsunuma

Keyword(s):

Drug Design ◽

Allergic Inflammation ◽

New Drug ◽

Ige Mediated

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Triptolide: reflections on two decades of research and prospects for the future

Natural Product Reports ◽

10.1039/d0np00054j ◽

2020 ◽

Author(s):

Lu Tong ◽

Qunfei Zhao ◽

Emmanuel Datan ◽

Guo-Qiang Lin ◽

Il Minn ◽

...

Keyword(s):

Drug Design ◽

Molecular Mechanisms ◽

Medicinal Herb ◽

Design Strategies ◽

Chinese Medicinal Herb ◽

New Drug ◽

The Future

This review highlights advances in material sourcing, molecular mechanisms, clinical progress and new drug design strategies for triptolide from a Chinese medicinal herb, along with some prospects for the future course of development of triptolide.

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