Exploring the Ribose Sub-Pocket of the Substrate-Binding Site in Escherichia coli IspE: Structure-Based Design, Synthesis, and Biological Evaluation of Cytosines and Cytosine Analogues

Andri P. Schütz; Sho Osawa; Jennifer Mathis; Anna K. H. Hirsch; Bruno Bernet; Boris Illarionov; Markus Fischer; Adelbert Bacher; François Diederich

doi:10.1002/ejoc.201200296

Exploring the Ribose Sub-Pocket of the Substrate-Binding Site in Escherichia coli IspE: Structure-Based Design, Synthesis, and Biological Evaluation of Cytosines and Cytosine Analogues

European Journal of Organic Chemistry ◽

10.1002/ejoc.201200296 ◽

2012 ◽

Vol 2012 (17) ◽

pp. 3278-3287 ◽

Cited By ~ 6

Author(s):

Andri P. Schütz ◽

Sho Osawa ◽

Jennifer Mathis ◽

Anna K. H. Hirsch ◽

Bruno Bernet ◽

...

Keyword(s):

Escherichia Coli ◽

Binding Site ◽

Substrate Binding ◽

Biological Evaluation ◽

Design Synthesis ◽

Substrate Binding Site ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of new carbazole-coumarin hybrids as dual binding site inhibitors of acetylcholinesterase

Journal of Molecular Structure ◽

10.1016/j.molstruc.2020.129784 ◽

2021 ◽

Vol 1229 ◽

pp. 129784

Author(s):

Meng-qiu Song ◽

Wei Min ◽

Jing Wang ◽

Xi-Xi Si ◽

Xiu-Jun Wang ◽

...

Keyword(s):

Binding Site ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00715 ◽

2021 ◽

Author(s):

Hao Chen ◽

Shanshan Deng ◽

Najah Albadari ◽

Mi-Kyung Yun ◽

Sicheng Zhang ◽

...

Keyword(s):

Binding Site ◽

Anticancer Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Tubulin Inhibitors ◽

Colchicine Binding Site ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of 7H-Thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives as Dual Binding Site Acetylcholinesterase Inhibitors

Heterocycles ◽

10.3987/com-18-12820 ◽

2013 ◽

Vol 87 (12) ◽

Author(s):

Chun Hu ◽

Si-Jie Liu ◽

Li-Bo Cui ◽

Hiu-Lan Xu ◽

Tie-Ying Wang ◽

...

Keyword(s):

Binding Site ◽

Acetylcholinesterase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease-Modifying Agents for Alzheimer's Disease

Journal of Medicinal Chemistry ◽

10.1021/jm0503289 ◽

2005 ◽

Vol 48 (23) ◽

pp. 7223-7233 ◽

Cited By ~ 143

Author(s):

Pilar Muñoz-Ruiz ◽

Laura Rubio ◽

Esther García-Palomero ◽

Isabel Dorronsoro ◽

María del Monte-Millán ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Binding Site ◽

Acetylcholinesterase Inhibitors ◽

Biological Evaluation ◽

New Disease ◽

Design Synthesis ◽

Disease Modifying ◽

Disease Modifying Agents ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of resveratrol-cinnamoyl derivates as tubulin polymerization inhibitors targeting the colchicine binding site

Bioorganic Chemistry ◽

10.1016/j.bioorg.2019.103319 ◽

2019 ◽

Vol 93 ◽

pp. 103319 ◽

Cited By ~ 3

Author(s):

Yong Yin ◽

Bao-Ping Lian ◽

Yuan-Zheng Xia ◽

Yu-Ying Shao ◽

Ling-Yi Kong

Keyword(s):

Binding Site ◽

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

Colchicine Binding Site ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b00706 ◽

2019 ◽

Vol 62 (14) ◽

pp. 6734-6750 ◽

Cited By ~ 8

Author(s):

Qinghui Wang ◽

Kinsie E. Arnst ◽

Yuxi Wang ◽

Gyanendra Kumar ◽

Dejian Ma ◽

...

Keyword(s):

Binding Site ◽

Biological Evaluation ◽

Design Synthesis ◽

Colchicine Binding Site ◽

Synthesis And Biological Evaluation

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Expression in Escherichia coli of UDP-glucose pyrophosphorylase cDNA from potato tuber and functional assessment of the five lysyl residues located at the substrate-binding site

Biochemistry ◽

10.1021/bi00099a008 ◽

1991 ◽

Vol 30 (35) ◽

pp. 8546-8551 ◽

Cited By ~ 32

Author(s):

Takuya Katsube ◽

Yasuaki Kazuta ◽

Katsuyuki Tanizawa ◽

Toshio Fukui

Keyword(s):

Escherichia Coli ◽

Potato Tuber ◽

Binding Site ◽

Functional Assessment ◽

Substrate Binding ◽

Substrate Binding Site ◽

Expression In Escherichia Coli

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Cysteine 148 in the Lactose Permease of Escherichia coli Is a Component of a Substrate Binding Site. 1. Site-Directed Mutagenesis Studies

Biochemistry ◽

10.1021/bi00206a019 ◽

1994 ◽

Vol 33 (40) ◽

pp. 12160-12165 ◽

Cited By ~ 33

Author(s):

Heinrich Jung ◽

Kirsten Jung ◽

H. Ronald Kaback

Keyword(s):

Escherichia Coli ◽

Binding Site ◽

Substrate Binding ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Lactose Permease ◽

Substrate Binding Site

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Conformational flexibility at the substrate binding site in the lactose permease of Escherichia coli

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.96.20.11178 ◽

1999 ◽

Vol 96 (20) ◽

pp. 11178-11182 ◽

Cited By ~ 16

Author(s):

A. B. Weinglass ◽

H. R. Kaback

Keyword(s):

Escherichia Coli ◽

Binding Site ◽

Substrate Binding ◽

Conformational Flexibility ◽

Lactose Permease ◽

Substrate Binding Site

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Design, synthesis and biological evaluation of novel 2-methylpyrimidine-4-ylamine derivatives as inhibitors of Escherichia coli pyruvate dehydrogenase complex E1

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.01.019 ◽

2012 ◽

Vol 20 (5) ◽

pp. 1665-1670 ◽

Cited By ~ 24

Author(s):

Junbo He ◽

Lingling Feng ◽

Jing Li ◽

Ruijuan Tao ◽

Fang Wang ◽

...

Keyword(s):

Escherichia Coli ◽

Pyruvate Dehydrogenase ◽

Pyruvate Dehydrogenase Complex ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Dehydrogenase Complex

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