Integrating micro metal‐air batteries in lateral flow test for point‐of‐care applications

2020 ◽  
Author(s):  
Yifei Wang ◽  
Wending Pan ◽  
Shijing Luo ◽  
Xiaolong Zhao ◽  
Holly Y. H. Kwok ◽  
...  
Keyword(s):  
Point Of Care ◽  
Lateral Flow ◽  
Flow Test ◽  
Lateral Flow Test

Diagnostic ability of salivary matrix metalloproteinase‐9 lateral flow test point‐of‐care test for periodontitis

2020 ◽  
Vol 47 (11) ◽  
pp. 1354-1361
Author(s):  
Hyun‐Duck Kim ◽  
Chang‐Soo Lee ◽  
Hyun‐Jae Cho ◽  
Sumin Jeon ◽  
Young‐Nim Choi ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Point Of Care ◽  
Test Point ◽  
Matrix Metalloproteinase 9 ◽  
Lateral Flow ◽  
Diagnostic Ability ◽  
Point Of Care Test ◽  
Flow Test ◽  
Lateral Flow Test ◽  
Metalloproteinase 9

scholarly journals Eliminating viscosity bias in lateral flow tests

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Daniel M. Kainz ◽  
Bastian J. Breiner ◽  
Susanna M. Früh ◽  
Tobias Hutzenlaub ◽  
Roland Zengerle ◽  
...  
Keyword(s):  
Point Of Care ◽  
Lateral Flow ◽  
Nitrocellulose Membrane ◽  
Widespread Application ◽  
Significant Challenge ◽  
Microfluidic Flow ◽  
Flow Test ◽  
Lateral Flow Test ◽  
Lateral Flow Tests ◽  
Viscosity Dependence

AbstractDespite the widespread application of point-of-care lateral flow tests, the viscosity dependence of these assay results remains a significant challenge. Here, we employ centrifugal microfluidic flow control through the nitrocellulose membrane of the strip to eliminate the viscosity bias. The key feature is the balancing of the sample flow into the cassette of the lateral flow test with the air flow out of the cassette. A viscosity-independent flow rate of 3.01 ± 0.18 µl/min (±6%) is demonstrated for samples with viscosities ranging from 1.1 mPas to 24 mPas, a factor greater than 20. In a model human IgG lateral flow assay, signal-intensity shifts caused by varying the sample viscosity from 1.1 mPas to 2.3 mPas could be reduced by more than 84%.

scholarly journals A low-cost smartphone-based platform for highly sensitive point-of-care testing with persistent luminescent phosphors

Lab on a Chip ◽  
2017 ◽  
Vol 17 (6) ◽  
pp. 1051-1059 ◽  
Author(s):  
Andrew S. Paterson ◽  
Balakrishnan Raja ◽  
Vinay Mandadi ◽  
Blane Townsend ◽  
Miles Lee ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Test Strip ◽  
Lateral Flow ◽  
Point Of Care Testing ◽  
Flow Test ◽  
Highly Sensitive ◽  
Lateral Flow Test ◽  
Gated Imaging

Time-gated imaging on a smartphone of a lateral flow test strip run with persistent luminescent nanophosphors.

scholarly journals Point-of-Care Diagnoses and Assays Based on Lateral Flow Test

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Miroslav Pohanka
Keyword(s):  
Quality Of Life ◽  
Point Of Care ◽  
Lateral Flow ◽  
Improve Quality ◽  
New Materials ◽  
Flow Test ◽  
Lateral Flow Test ◽  
Lateral Flow Tests

Analytical devices for point-of-care diagnoses are highly desired and would improve quality of life when first diagnoses are made early and pathologies are recognized soon. Lateral flow tests (LFTs) are such tools that can be easily performed without specific equipment, skills, or experiences. This review is focused on the use of LFT in point-of-care diagnoses. The principle of the assay is explained, and new materials like nanoparticles for labeling, new recognition molecules for interaction with an analyte, and new additional instrumentation like signal scaling by a smartphone camera are described and discussed. Advantages of the LFT devices as well as their limitations are described and discussed here considering actual papers that are properly cited.

scholarly journals Diagnostic validation of a rapid and field-applicable PCR-lateral flow test system for point-of-care detection of cyprinid herpesvirus 3 (CyHV-3)

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0241420
Author(s):  
Finn N. Loose ◽  
André Breitbach ◽  
Ivo Bertalan ◽  
Dana Rüster ◽  
Uwe Truyen ◽  
...  
Keyword(s):  
Point Of Care ◽  
Test System ◽  
Lateral Flow ◽  
Cyprinid Herpesvirus 3 ◽  
Flow Test ◽  
Diagnostic Validation ◽  
Lateral Flow Test ◽  
Point Of Care Detection

scholarly journals Evaluation of Production Lots of a Rapid Point-of-Care Lateral Flow Serological Test Intended for Identification of IgM and IgG against the N-Terminal Part of the Spike Protein (S1) of SARS-CoV-2

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1043
Author(s):  
Tove Hoffman ◽  
Linda Kolstad ◽  
Bengt Rönnberg ◽  
Åke Lundkvist
Keyword(s):  
Predictive Value ◽  
Serological Test ◽  
Point Of Care ◽  
External Validation ◽  
High Sensitivity ◽  
Lateral Flow ◽  
Spike Protein ◽  
Individual Level ◽  
Lateral Flow Test ◽  
Production Errors

The potential of rapid point-of-care (POC) tests has been subject of doubt due to an eventual risk of production errors. The aim was therefore to evaluate the two separate production lots of a commercial POC lateral flow test, intended for the detection of IgM and IgG against the SARS-CoV-2 spike protein (S1). Control samples consisted of serum from individuals with confirmed SARS-CoV-2 infection and pre-COVID-19 negative sera gathered from a biobank. The presence of anti-S1 IgM/IgG in the sera was verified by an in-house Luminex-based serological assay (COVID-19 SIA). One hundred samples were verified as positive for anti-S1 IgG and 74 for anti-S1 IgM. Two hundred samples were verified as negative for anti-S1 IgM/IgG. For the two lots of the POC-test, the sensitivities were 93.2% and 87.8% for IgM and 93.0% and 100% for IgG. The specificities were 100% for IgM and 99.5% for IgG. The positive predictive value was 100% for IgM and 98.9% and 99.0% for IgG. The negative predictive value was 97.6% and 95.7% for IgM, and 96.6% and 100% for IgG. The evaluated POC-test is suitable to assess anti-SARS-CoV-2 S1 IgM and IgG, as a measure of previous virus exposure on an individual level. The external validation of separate lots of rapid POC-tests is encouraged to ensure high sensitivity before market introduction.

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