Effects of corn syrup solids containing maltobionic acid (maltobionic acid calcium salt) on bone resorption in healthy Japanese adult women: A randomized double‐blind placebo‐controlled crossover study

Background: Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk, with a higher incidence in post-menopausal women. This study aimed to evaluate the safety and efficacy of long-term ingestion of corn syrup solids containing maltobionic acid on BMD in healthy Japanese women.Methods: A randomized, double-blind, placebo-controlled, parallel-group study was conducted from February to December 2018. Thirty-eight healthy Japanese women aged 50–69 years who were at least 1 year past the onset of natural menopause were allocated to two groups (19 in each group) using a computerized random-number generator: one in which participants ingested 7 g of corn syrup containing maltobionic acid and another in which participants ingested 7 g of placebo (maltose syrup) group per day for 24 weeks. BMD and bone metabolism parameters were measured by DEXA (dual-energy X-ray absorptiometry method) and a peripheral blood test, respectively, while safety was evaluated via a physical examination, peripheral blood test, urinalysis, assessment of subjective symptoms, and a medical questionnaire.Results: Thirty-three subjects completed the study, except for one subject who discontinued the study halfway, and there were no adverse events related to consumption of the test food. Fourteen subjects were excluded before the efficacy analysis because of conflict with control criteria; the remaining 23 subjects were studied (10 in the Test food group and 13 in the Placebo group). Consumption of corn syrup solids containing maltobionic acid was maintained during the intervention period, and BMD, bone mineral content (BMC), and YAM (young adult mean) values were found to be improved (P < 0.05). No safety concerns were observed during the intervention period.Conclusion: These results indicate that the consumption of corn syrup solids containing maltobionic acid may contribute to the prevention of osteoporosis.

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Acute Epigallocatechin 3 Gallate (EGCG) Supplementation Delays Gastric Emptying in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

Nutrients ◽

10.3390/nu10081122 ◽

2018 ◽

Vol 10 (8) ◽

pp. 1122 ◽

Cited By ~ 5

Author(s):

Renata Fernandes ◽

Vanessa Araújo ◽

Bruna Giglio ◽

Ana Marini ◽

João Mota ◽

...

Keyword(s):

Gastric Emptying ◽

Crossover Study ◽

Corn Starch ◽

Gastric Volume ◽

Adult Women ◽

Appetite Control ◽

Double Blind ◽

Double Blind Placebo ◽

Healthy Women ◽

Hormonal Modulation

Background: Epigallocatechin 3 Gallate (EGCG) appears to act in appetite control through hormonal modulation. However, there is a lack of elucidation of EGCG’s action mechanisms, especially in humans. The aim of this study was to evaluate the effects of acute EGCG supplementation on gastric emptying and its relation to blood hormones, glucose and appetite perceptions in healthy women. Methods: 22 healthy adult women were included in a randomized, double-blind, placebo-controlled crossover study. On two separate occasions, 1 week apart from each other, we offered 800 mg of corn starch (placebo) or 752 mg of EGCG. Appetite was assessed through gastric emptying; perceptions of hunger, desire to eat and satiation; and plasma insulin, adiponectin, leptin and glucose concentrations. The evaluations were carried out in fasting, 30, 90 and 150 min after supplementation. Results: EGCG supplementation induced higher relative gastric volume at 30 and 90 min. Satiation at 90 min was higher in the EGCG group. Adiponectin concentrations at 150 min were higher with EGCG, but no difference was found for glucose, insulin and leptin concentrations. Conclusions: Acute EGCG supplementation is able to delay gastric emptying in healthy women to a small, but statistically significant extent. This study was registered at the Brazilian Registry of Clinical Trials (ReBEC) as RBR-9svwrv.

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Caffeine Improves Endurance in 75-Yr-Old Citizens: A Randomized, Double-blind, Placebo-controlled, Crossover Study

Yearbook of Sports Medicine ◽

10.1016/s0162-0908(08)70479-3 ◽

2006 ◽

Vol 2006 ◽

pp. 342-344

Author(s):

R.J. Shephard

Keyword(s):

Crossover Study ◽

Double Blind ◽

Double Blind Placebo

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Luteal Phase Sertraline Treatment for Premenstrual Dysphoric Disorder: Results of a Double-blind, Placebo-Controlled, Crossover Study

Archives of Family Medicine ◽

10.1001/archfami.8.4.328 ◽

1999 ◽

Vol 8 (4) ◽

pp. 328-332 ◽

Cited By ~ 68

Author(s):

D. M. Jermain

Keyword(s):

Crossover Study ◽

Luteal Phase ◽

Premenstrual Dysphoric Disorder ◽

Double Blind ◽

Double Blind Placebo

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Effect of Stevia on Glycemic and Insulin Responses in Obese Patients—A Randomized, Double-Blind, Placebo-Controlled Crossover Study

Diabetes ◽

10.2337/db18-790-p ◽

2018 ◽

Vol 67 (Supplement 1) ◽

pp. 790-P

Author(s):

PARINYA SAMAKKARNTHAI ◽

MANAPORN PAYANUNDANA ◽

NATTAPOL SATHAVARODOM ◽

CHONPITI SIRIWAN ◽

APUSSANEE BOONYAVARAKUL

Keyword(s):

Crossover Study ◽

Obese Patients ◽

Double Blind ◽

Double Blind Placebo ◽

Insulin Responses

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Faculty of 1000 evaluation for Randomized double-blind placebo-controlled crossover study of efficacy of pollen blocker cream for perennial allergic rhinitis.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718056094.793482414 ◽

2013 ◽

Author(s):

Phillip Lieberman ◽

Jay Lieberman

Keyword(s):

Allergic Rhinitis ◽

Crossover Study ◽

Perennial Allergic Rhinitis ◽

Double Blind ◽

Double Blind Placebo

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Acute and Short-term Chronic Testosterone Fluctuation Effects on Glucose Homeostasis, Insulin Sensitivity, and Adiponectin: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2013-2807 ◽

2014 ◽

Vol 99 (6) ◽

pp. E1088-E1096 ◽

Cited By ~ 14

Author(s):

Christian Høst ◽

Lars C. Gormsen ◽

David M. Hougaard ◽

Jens S. Christiansen ◽

Steen B. Pedersen ◽

...

Keyword(s):

Molecular Weight ◽

Glucose Metabolism ◽

Crossover Study ◽

High Molecular Weight ◽

Glucose Disposal ◽

Short Term ◽

High Molecular Weight Adiponectin ◽

Double Blind ◽

Double Blind Placebo ◽

Total Glucose

Context: Low levels of adiponectin and T in men have been shown to predict development of the metabolic syndrome, but the effects of T on glucose metabolism are incompletely understood and may be influenced either directly or indirectly through changes in body composition or in levels of adiponectin. Objective: The aim of the study was to test whether T exerts its effects on glucose metabolism directly or indirectly. Design, Setting, and Participants: In a randomized, double-blind, placebo-controlled, crossover study, 12 healthy young males were studied on four separate occasions. They received GnRH agonist treatment 1 month before 3 of 4 trial days to induce castrate levels of T. On trial days, T gel containing either high or low physiological T dose or placebo was applied to the body. On a fourth trial day, participants constituted their own eugonadal controls. Intervention: Each study comprised a 5-hour basal period and a 3-hour hyperinsulinemic euglycemic clamp. Main Outcome Measures: We measured the effect of acute T on peripheral glucose disposal, total adiponectin and subforms, and other indices of glucose metabolism. Results: Short-term hypogonadism was associated with increased high molecular weight adiponectin levels (P < .03) and increased oxidative glucose disposal (P = .03) but not total glucose disposal (P = .07). Acute T treatment was an independent suppressor of high molecular weight adiponectin levels (P = .04) but did not affect total glucose disposal (P = .17). Conclusions: These data show that T can act through putative fast nongenomic pathways to affect adiponectin levels in humans. The early hypogonadal state is characterized by a marked shift in fuel oxidation from lipids toward glucose, which may rely partly on buffering capabilities of adiponectin.

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