Gene expression meta-analysis identifies chromosomal regions involved in ovarian cancer survival

Background: A number of observational studies examined the association between metformin therapy and ovarian cancer survival outcomes, but the results are inconsistent. Objective: The study aimed to investigate the effect of metformin on survival for ovarian cancer patients. Methods: PubMed, Embase and Web of Science databases were searched for relevant studies from the inception to June 11, 2019. The strength of the relationship was assessed using summary of hazard ratios (HRs) with corresponding 95% confidence intervals (CI). Statistical analyses were carried out using the random-effects model. Results: Totally, 6 retrospective cohort studies involving 2,638 ovarian cancer patients were included. Metformin was not associated with improved overall survival (HR=0.78, 95% CI 0.54-1.12, P=0.175, I2= 61.6%) and disease- free survival (HR=0.49, 95% CI 0.20-1.17, P=0.106, I2=82.1%) in ovarian cancer patients compared to nonmetformin users. Conclusion: The current study provides preliminary evidence that metformin may not be associated with a survival benefit for ovarian cancer patients. More studies with rigorous designs are needed.

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Sarcopenia and ovarian cancer survival: a systematic review and meta‐analysis

Journal of Cachexia Sarcopenia and Muscle ◽

10.1002/jcsm.12468 ◽

2019 ◽

Vol 10 (6) ◽

pp. 1165-1174 ◽

Cited By ~ 16

Author(s):

Jorne Ubachs ◽

Janine Ziemons ◽

Iris J.G. Minis‐Rutten ◽

Roy F.P.M. Kruitwagen ◽

Jos Kleijnen ◽

...

Keyword(s):

Systematic Review ◽

Ovarian Cancer ◽

Cancer Survival ◽

Meta Analysis ◽

Ovarian Cancer Survival

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Obesity and Ovarian Cancer Survival: A Systematic Review and Meta-analysis

Cancer Prevention Research ◽

10.1158/1940-6207.capr-12-0048 ◽

2012 ◽

Vol 5 (7) ◽

pp. 901-910 ◽

Cited By ~ 84

Author(s):

Melinda M. Protani ◽

Christina M. Nagle ◽

Penelope M. Webb

Keyword(s):

Systematic Review ◽

Ovarian Cancer ◽

Cancer Survival ◽

Meta Analysis ◽

Ovarian Cancer Survival

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Obesity and epithelial ovarian cancer survival: a systematic review and meta-analysis

Journal of Ovarian Research ◽

10.1186/1757-2215-7-41 ◽

2014 ◽

Vol 7 (1) ◽

pp. 41 ◽

Cited By ~ 35

Author(s):

Hyo Bae ◽

Hyun Kim ◽

Jin Hong ◽

Jae Lee ◽

Nak Lee ◽

...

Keyword(s):

Systematic Review ◽

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Cancer Survival ◽

Meta Analysis ◽

Ovarian Cancer Survival

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Vaginal hysterectomy with or without bilateral salpingo-oophorectomy may be an alternative treatment for endometrial cancer patients with medical co-morbidities precluding standard surgical procedures: a systematic review

International Journal of Gynecological Cancer ◽

10.1136/ijgc-2018-000015 ◽

2019 ◽

Vol 29 (2) ◽

pp. 299-304 ◽

Cited By ~ 1

Author(s):

Arnold-Jan Kruse ◽

Henk G ter Brugge ◽

Harm H de Haan ◽

Hugo W Van Eyndhoven ◽

Hans W Nijman

Keyword(s):

Ovarian Cancer ◽

Endometrial Cancer ◽

Vaginal Hysterectomy ◽

Cancer Survival ◽

Survival Rates ◽

Survival Outcomes ◽

Ovarian Malignancy ◽

Post Menopausal ◽

Ovarian Cancer Survival ◽

Overall Survival Rates

ObjectiveVaginal hysterectomy with bilateral salpingo-oophorectomy may be an alternative strategy for patients with low-risk endometrial cancer and medical co-morbidities precluding laparoscopic or abdominal procedures. The current study evaluates the prevalence of co-existent ovarian malignancy in patients with endometrial cancer and the influence of bilateral salpingo-oophorectomy on survival outcomes in these patients.MethodsMedline and EMBASE were searched for studies published between January 1, 2000 and November 20, 2017 that investigated (1) the prevalence of co-existing ovarian malignancy (either metastases or primary synchronous ovarian cancer in women with endometrial cancer, and (2) the influence of bilateral salpingo-oophorectomy on recurrence and/or survival rates.ResultsOf the pre-menopausal and post-menopausal patients (n=6059), 373 were identified with metastases and 106 were identified with primary synchronous ovarian cancer. Of the post-menopausal patients (n=6016), 362 were identified with metastases and 44 were identified with primary synchronous ovarian cancer. Survival outcomes did not differ for pre-menopausal patients with endometrial cancer with and without bilateral salpingo-oophorectomy (5-year overall survival rates were 89–94.5% and 86–97.8%, respectively).ConclusionBilateral salpingo-oophorectomy during vaginal hysterectomy seems to have a limited impact on disease outcome in patients with endometrial cancer. These results support the view that vaginal hysterectomy alone or with bilateral salpingo-oophorectomy may be an option for patients with endometrial cancer who are not ideal surgical candidates.

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