Functional expression of constitutive nitric oxide synthases regulated by voltage-gated Na+ and Ca2+ channels in cultured human astrocytes

Glia ◽  
2004 ◽  
Vol 46 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Michiko Oka ◽  
Miyuki Wada ◽  
Akira Yamamoto ◽  
Yoshinori Itoh ◽  
Takuya Fujita
Keyword(s):  
Nitric Oxide ◽  
Functional Expression ◽  
Nitric Oxide Synthases ◽  
Voltage Gated ◽  
Human Astrocytes ◽  
Ca2 Channels

Nitric oxide augments voltage-gated P/Q-type Ca2+ channels constituting a putative positive feedback loop

2002 ◽  
Vol 32 (7) ◽  
pp. 638-649 ◽  
Author(s):  
Jianguo Chen ◽  
Heather Daggett ◽  
Michel De Waard ◽  
S.H Heinemann ◽  
Toshinori Hoshi
Keyword(s):  
Nitric Oxide ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Positive Feedback Loop ◽  
Voltage Gated ◽  
Ca2 Channels

scholarly journals The life cycle of voltage-gated Ca2+ channels in neurons: an update on the trafficking of neuronal calcium channels

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Laurent Ferron ◽  
Saloni Koshti ◽  
Gerald W. Zamponi
Keyword(s):  
Plasma Membrane ◽  
Intracellular Signaling ◽  
Critical Role ◽  
Functional Expression ◽  
Current Evidence ◽  
Precise Control ◽  
Channel Trafficking ◽  
Voltage Gated ◽  
Cellular Excitability ◽  
Ca2 Channels

Abstract Neuronal voltage-gated Ca2+ (CaV) channels play a critical role in cellular excitability, synaptic transmission, excitation–transcription coupling and activation of intracellular signaling pathways. CaV channels are multiprotein complexes and their functional expression in the plasma membrane involves finely tuned mechanisms, including forward trafficking from the endoplasmic reticulum (ER) to the plasma membrane, endocytosis and recycling. Whether genetic or acquired, alterations and defects in the trafficking of neuronal CaV channels can have severe physiological consequences. In this review, we address the current evidence concerning the regulatory mechanisms which underlie precise control of neuronal CaV channel trafficking and we discuss their potential as therapeutic targets.

Nitric oxide reduces Ca2+ and Zn2+ influx through voltage-gated Ca2+ channels and reduces Zn2+ neurotoxicity

Neuroscience ◽  
2000 ◽  
Vol 100 (3) ◽  
pp. 651-661 ◽  
Author(s):  
B.J Snider ◽  
J Choi ◽  
D.M Turetsky ◽  
L.M.T Canzoniero ◽  
S.L Sensi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Voltage Gated ◽  
Ca2 Channels

Nitric Oxide and Voltage-Gated Ca2+ Channels

2004 ◽  
pp. 137-155 ◽  
Author(s):  
Claudio Grassi ◽  
Marcello D’Ascenzo ◽  
Gian Battista Azzena
Keyword(s):  
Nitric Oxide ◽  
Voltage Gated ◽  
Ca2 Channels
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