Distant metastases from cutaneous squamous cell carcinoma-analysis of AJCC stage IV

Head & Neck ◽  
2012 ◽  
Vol 35 (1) ◽  
pp. 72-75 ◽  
Author(s):  
Markus Brunner ◽  
Michael J. Veness ◽  
Sydney Ch'ng ◽  
Michael Elliott ◽  
Jonathan R. Clark
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Stage Iv ◽  
Distant Metastases ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Ajcc Stage

Chemoradiotherapy could improve overall survival of patients with stage IV cutaneous squamous cell carcinoma: analysis of 34 cases

2019 ◽  
Vol 180 (6) ◽  
pp. 1557-1558 ◽  
Author(s):  
A. Hiura ◽  
K. Yoshino ◽  
T. Maeda ◽  
K. Nagai ◽  
S. Oaku ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Stage Iv ◽  
Cutaneous Squamous Cell Carcinoma

Incidence of brain metastasis from esophageal cancer.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 165-165
Author(s):  
Jonathan Ben Ashman ◽  
Gabrielle Welch ◽  
Naresh P. Patel ◽  
Dawn E. Jaroszewski ◽  
David Fleischer ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Cell Carcinoma ◽  
Surgical Resection ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Stage Iv ◽  
Distant Metastases ◽  
Primary Diagnosis ◽  
Histologic Subtype

165 Background: Distant metastases are common in primary esophageal cancer, but data conflict regarding the rates of brain metastases (BM) ranging from 0% to 13%. We sought to investigate whether the incidence of BM from esophageal malignancies is increasing in the modern era. Methods: After IRB approval, a single institution retrospective review identified 583 patients (pts) treated between 1/1997 and 1/2016 for stage I-IV cancer of the esophagus/esophagogastric junction with at least 3 months follow-up. Data collected included demographic information, primary diagnosis date and staging, histologic subtype, treatment regimens for primary and BM, date of BM diagnosis, status of neurologic symptoms and extracranial disease at BM diagnosis, and date of death. Data were analyzed by Fischer’s exact test and Kaplan-Meier analysis. Results: The overall cohort was comprised of 495 pts (85%) with adenocarcinoma and 82 pts (14%) with squamous cell carcinoma. 492 pts (84%) were male; the median age was 68 years (range 26-90). BM were identified in 22 pts (3.8%) with a median latency of 11 months from the primary diagnosis. Of the pts with BM, the primary histology was adenocarcinoma in 21 pts and squamous cell carcinoma in 1 pt ( P = 0.3). BM developed in 12 pts who were initially treated for locally advanced disease and in 10 pts who presented with distant metastases. Diagnosis of BM was at the time of initial presentation in 4 of these 10 stage IV pts. A solitary BM was identified in 9 pts. Initial treatments of BM were surgical resection followed by stereotactic radiosurgery (SRS; n = 5); surgical resection followed by whole brain radiotherapy (WBRT; n = 1); WBRT alone (n = 13); SRS alone (n = 3). Overall survival (OS) following diagnosis of BM was 18% at 1 year with a median of 4 months. OS was superior for pts who had surgical resection as initial treatment of BM compared to pts treated with WBRT or SRS alone (1-year OS 67 vs. 0%; median OS 13.5 vs. 3 months; P = 0.003). Conclusions: The incidence of BM is low in esophageal cancer with no statistically significant increased rate of BM developing in patients with adenocarcinoma compared with squamous cell carcinoma. Outcomes were poor overall for pts who developed BM, but pts who were appropriate for neurosurgical resection had improved survival.

Stage IV cutaneous squamous cell carcinoma: treatment outcomes in a series of 42 patients

2019 ◽  
Vol 34 (6) ◽  
pp. 1202-1209 ◽  
Author(s):  
M. Chapalain ◽  
B. Baroudjian ◽  
A. Dupont ◽  
R. Lhote ◽  
J. Lambert ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Treatment Outcomes ◽  
Squamous Cell ◽  
Stage Iv ◽  
Cutaneous Squamous Cell Carcinoma

A favorable subset of AJCC stage IV squamous cell carcinoma of the head and neck

1984 ◽  
Vol 10 (10) ◽  
pp. 1841-1843 ◽  
Author(s):  
William M. Mendenhall ◽  
James T. Parsons ◽  
Rodney R. Million ◽  
Nicholas J. Cassisi ◽  
John W. Devine ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Stage Iv ◽  
Ajcc Stage

scholarly journals Case Report: Cetuximab and nivolumab use in advanced cutaneous squamous cell carcinoma resistant to chemotherapy

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 933
Author(s):  
Alvise Sernicola ◽  
Salvatore Lampitelli ◽  
Federica Marraffa ◽  
Patrizia Maddalena ◽  
Sara Grassi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Single Agent ◽  
Growth Factor Receptor ◽  
Stage Iv ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Whole Body ◽  
Combination Regimen ◽  
Whole Body Ct

We present the case of a 60-year-old man with unresectable cutaneous squamous cell carcinoma (cSCC) of the sternal area, which was not amenable to radiation therapy (stage III, T3N0M0). The treatment history of this patient is remarkable as the disease had progressed through all lines of conventional therapy established in the literature. The patient was treated with epidermal growth factor receptor (EGFR) inhibitor cetuximab for 35 cycles and restaged after 12 months of therapy with a whole body CT scan, documenting stage IV disease (T3N2bM1). The use of cetuximab as a single agent was effective for a limited time and we decided to initiate combination therapy with cetuximab and nivolumab. Restaging after six months of this combination regimen documented stable disease.

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