Clinical results of definitive chemoradiotherapy for cervical esophageal cancer: Comparison of failure pattern and toxicities between intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy

Head & Neck ◽  
2017 ◽  
Vol 39 (12) ◽  
pp. 2406-2415 ◽  
Author(s):  
Makoto Ito ◽  
Takeshi Kodaira ◽  
Hiroyuki Tachibana ◽  
Natsuo Tomita ◽  
Chiyoko Makita ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Intensity Modulated Radiotherapy ◽  
Conformal Radiotherapy ◽  
Clinical Results ◽  
Failure Pattern ◽  
Cervical Esophageal Cancer ◽  
Definitive Chemoradiotherapy ◽  
3 Dimensional ◽  
Intensity Modulated

scholarly journals Intensity-modulated radiotherapy reduces toxicity with similar biochemical control compared with 3-dimensional conformal radiotherapy for prostate cancer: A randomized clinical trial

Cancer ◽  
2016 ◽  
Vol 122 (13) ◽  
pp. 2004-2011 ◽  
Author(s):  
Gustavo Arruda Viani ◽  
Bruno Silveira Viana ◽  
Jose Eduardo Chicareli Martin ◽  
Bruno Tiago Rossi ◽  
Gisele Zuliani ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Intensity Modulated Radiotherapy ◽  
Conformal Radiotherapy ◽  
Biochemical Control ◽  
3 Dimensional ◽  
Intensity Modulated

scholarly journals Comparison between Intensity-Modulated Radiotherapy and Three-Dimensional Conformal Radiotherapy for Their Effectiveness in Esophageal Cancer Treatment: A Retrospective Single Institution Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Xing-hua Bai ◽  
Jun Dang ◽  
Zhi-qin Chen ◽  
Zheng He ◽  
Guang Li
Keyword(s):  
Esophageal Cancer ◽  
Radiation Therapy ◽  
Locally Advanced ◽  
Three Dimensional ◽  
Intensity Modulated Radiotherapy ◽  
Conformal Radiotherapy ◽  
Intensity Modulated ◽  
Three Dimensional Conformal Radiotherapy ◽  
3D Crt

Although a large number of influential studies that have been conducted worldwide on locally advanced esophageal cancer (EC) have employed the treatment modality of three-dimensional conformal radiotherapy (3D-CRT), an advanced as well as highly conformal technology known as intensity-modulated radiotherapy (IMRT) has attracted increasing attention from the radiotherapy research community. This is because of the clear advantages of IMRT, including decrease in radiation dose that reaches critical cardiopulmonary organs. These two treatment modalities need to be investigated with regard to their effect on local control rate and patient survival. In addition, related clinical factors also need to be explored. Data from a total of 431 patients with locally advanced EC, who underwent radiation therapy between January 1, 2010 and December 31, 2013, were included in the present study. Two hundred and ninety-three patients received 3D-CRT, while 138 patients received IMRT. We constructed propensity score matches to make the two groups be comparable (136 patients in 3D-CRT group and 138 patients in IMRT group. Kaplan–Meier analysis was conducted to evaluate the endpoint of overall survival (OS). A Cox proportional hazards model was employed to analyze the relationship between the associated factors and the outcomes via univariate and multivariate approaches. The mean follow-up period was 36.2 months, and the median follow-up period was 23 months. For the IMRT group, the median OS was 31 months, and the 1-, 3-, and 5-year OS rates were 70.3%, 50.0%, and 42.8%, respectively, while for the 3D-CRT group, the median OS was 22 months, and the 1-, 3-, and 5-year OS rates were 63.2%, 41.0%, and 35.4%, respectively (p<0.05). The univariate analysis revealed that quit drinking, chemotherapy, and concurrent chemotherapy were significant risk factors for the prognosis of EC (p<0.05), as well as the radiation therapy technique used (p=0.052). The multivariate analysis indicated that chemotherapy and quit drinking were independent predictive factors for OS. OS is found to be significantly better in the IMRT group, compared with that of the 3D-CRT group. Even though these outcomes need further validation, IMRT should be considered preferentially as a therapeutic option for EC, in combination with chemotherapy and persuading patients to quit drinking.

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