Systematic review and meta‐analysis of racial survival disparities among oropharyngeal cancer cases by HPV status

Head & Neck ◽  
2020 ◽  
Vol 42 (10) ◽  
pp. 2985-3001 ◽  
Author(s):  
Eva Stein ◽  
Nicholas R. Lenze ◽  
Wendell G. Yarbrough ◽  
D. Neil Hayes ◽  
Angela Mazul ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oropharyngeal Cancer ◽  
Meta Analysis ◽  
Hpv Status

Racial disparities and human papillomavirus status in oropharyngeal cancer: A systematic review and meta-analysis

Head & Neck ◽  
2018 ◽  
Vol 41 (1) ◽  
pp. 256-261 ◽  
Author(s):  
Nicholas R. Lenze ◽  
Douglas R. Farquhar ◽  
Angela L. Mazul ◽  
Maheer M. Masood ◽  
Jose P. Zevallos
Keyword(s):  
Systematic Review ◽  
Human Papillomavirus ◽  
Racial Disparities ◽  
Oropharyngeal Cancer ◽  
Meta Analysis

Pathologic Markers in Surgically Treated HPV-Associated Oropharyngeal Cancer: Retrospective Study, Systematic Review, and Meta-analysis

2017 ◽  
Vol 126 (5) ◽  
pp. 365-374 ◽  
Author(s):  
Patrick Tassone ◽  
Meghan Crawley ◽  
Cory Bovenzi ◽  
Tingting Zhan ◽  
William Keane ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Retrospective Study ◽  
Head And Neck ◽  
Neck Cancer ◽  
Oropharyngeal Cancer ◽  
Meta Analysis ◽  
Cochrane Review ◽  
Extracapsular Extension ◽  
N Stage

Objective: Human papillomavirus–associated (HPV) oropharyngeal cancer is a unique clinical entity whose incidence is increasing. It is controversial whether traditional pathologic markers of aggressive head and neck cancer also apply in surgically treated HPV-associated disease. Study Design: Retrospective study, systematic review, and meta-analysis Data Sources: PubMed and Cochrane review. Review Methods: PubMed and Cochrane review were searched for published articles on surgically treated HPV-associated oropharyngeal cancer. Eligible studies were included in a meta-analysis of survival using several clinicopathologic markers as predictors. Surgically treated HPV-positive oropharyngeal cancer patients at our institution were studied retrospectively and added to the meta-analysis. Results: Eight published reports, plus our retrospective series, were included in the meta-analysis. This showed significant impact on event-free survival for T stage, nodal number, perineural invasion, and lymphovascular invasion (all P < .05) but not for N stage extracapsular extension ( P = ns). Conclusions: While many traditional clinico-pathologic markers of aggressive disease in head and neck cancer also impact survival in surgically treated HPV-associated oropharyngeal cancer, extracapsular extension may be less important.

HPV vaccine to end oropharyngeal cancer. A systematic review and meta-analysis

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Aikaterini Tsentemeidou ◽  
Georgios Fyrmpas ◽  
Marios Stavrakas ◽  
Konstantinos Vlachtsis ◽  
Elena Sotiriou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oropharyngeal Cancer ◽  
Hpv Vaccine ◽  
Meta Analysis

scholarly journals p53 Arg72Pro Polymorphism, HPV Status and Initiation, Progression, and Development of Cervical Cancer: A Systematic Review and Meta-Analysis

2012 ◽  
Vol 18 (23) ◽  
pp. 6407-6415 ◽  
Author(s):  
Steven Habbous ◽  
Vincent Pang ◽  
Lawson Eng ◽  
Wei Xu ◽  
Goldie Kurtz ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cervical Cancer ◽  
Meta Analysis ◽  
Hpv Status ◽  
P53 Arg72pro Polymorphism

scholarly journals 53: Utility of Post-Treatment Pet in Hpv Associated Oropharyngeal Cancer: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 150 ◽  
pp. S26
Author(s):  
Pencilla Lang ◽  
Sondos Zayed ◽  
Andrew Warner ◽  
Gabriel Boldt ◽  
Lucas Mendez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oropharyngeal Cancer ◽  
Meta Analysis ◽  
Post Treatment

Quality of life in survivors of oropharyngeal cancer: A systematic review and meta-analysis of 1366 patients

2017 ◽  
Vol 78 ◽  
pp. 91-102 ◽  
Author(s):  
Sanne Høxbroe Michaelsen ◽  
Christian Grønhøj ◽  
Jacob Høxbroe Michaelsen ◽  
Jeppe Friborg ◽  
Christian von Buchwald
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Oropharyngeal Cancer ◽  
Meta Analysis

scholarly journals Human Papillomavirus and Survival of Sinonasal Squamous Cell Carcinoma Patients: A Systematic Review and Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3677
Author(s):  
Anish Sharma ◽  
Alice L. Tang ◽  
Vinita Takiar ◽  
Trisha M. Wise-Draper ◽  
Scott M. Langevin
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Statistical Power ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Hpv Status ◽  
The Impact

Human papillomavirus (HPV) is detectable in a subset of sinonasal squamous cell carcinoma (SNSCC), but the impact on patient outcomes is presently unclear due to a modest number of studies with limited statistical power. Therefore, we conducted a systematic review and meta-analysis to better clarify this relationship. A PubMed search was conducted to identify all studies reporting on overall (OS) or disease-free survival (DFS) for SNSCC by HPV status. Hazard ratios (HR) and corresponding 95% confidence intervals (CI) were extracted or, when not provided, indirectly estimated from each manuscript. Summary survival curves for 5-year OS and estimating survival probability by HPV status at pre-specified time intervals from study-specific Kaplan-Meier curves generated 2-year DFS. Log HRs and log CIs were combined across studies to generate summary estimates and a corresponding 95% CIs for OS and DFS. We identified ten unique studies reporting on OS and four for DFS. We observed a significant association between HPV and OS (summary HR = 0.51, 95% CI: 0.38–0.70) with relatively low heterogeneity between studies. These results indicate that HPV is a significant predictor of more favorable survival for SNSCC, and thus may be a useful biomarker for prognostication and, potentially, treatment modulation.

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