Letter to Editor: Author’s Reply ‐ Serum alanine transaminase activity beyond 100 times the upper limit of normal value doesn’t fit with acute fatty liver of pregnancy alone

Hepatology ◽  
2021 ◽  
Author(s):  
Mimi Wong ◽  
Nirjhar Nandi
Keyword(s):  
Fatty Liver ◽  
Alanine Transaminase ◽  
Transaminase Activity ◽  
Normal Value ◽  
Upper Limit ◽  
Acute Fatty Liver

Letter to the Editor : serum aminotransferase activity beyond 100 times the upper limit of normal value doesn't suggest acute fatty liver of pregnancy alone

Hepatology ◽  
2021 ◽  
Author(s):  
Jacques Bernuau ◽  
Dominique Cazals‐Hatem ◽  
Valérie Vigrain ◽  
François Durand
Keyword(s):  
Fatty Liver ◽  
Aminotransferase Activity ◽  
Serum Aminotransferase ◽  
Normal Value ◽  
Upper Limit ◽  
Letter To The Editor ◽  
Acute Fatty Liver

Acute Fatty Liver of Pregnancy From 18 Weeks’ Gestation

Hepatology ◽  
2020 ◽  
Vol 71 (6) ◽  
pp. 2167-2169 ◽  
Author(s):  
Mimi Wong ◽  
Frances Hills ◽  
Katrina Vogler ◽  
Ibrahim Zardawi ◽  
Nirjhar Nandi
Keyword(s):  
Fatty Liver ◽  
Acute Fatty Liver

scholarly journals Direct Evidence for an Increase in Enzyme Level as the Basis for the Glucocorticoid-induced Increase in Glutamic-Alanine Transaminase Activity in Rat Liver

1962 ◽  
Vol 237 (10) ◽  
pp. PC3303-PC3305 ◽  
Author(s):  
Harold L. Segal ◽  
R.G. Rosso ◽  
Sarah Hopper ◽  
Morton M. Weber
Keyword(s):  
Rat Liver ◽  
Direct Evidence ◽  
Enzyme Level ◽  
Alanine Transaminase ◽  
Transaminase Activity

LIVER TRANSAMINASE ACTIVITY IN RIBOFLAVIN-DEFICIENT RATS

1962 ◽  
Vol 40 (8) ◽  
pp. 1065-1070 ◽  
Author(s):  
Sailen Mookerjea ◽  
S. C. Jamdar
Keyword(s):  
Protein Concentration ◽  
Flavin Adenine Dinucleotide ◽  
Alanine Transaminase ◽  
Transaminase Activity ◽  
Liver Transaminase ◽  
Liver Size ◽  
Riboflavin Deficient

Rats were deprived of riboflavin until there was established impairment of growth, hepatomegaly, and depletion of flavin–adenine dinucleotide and of catalase in the liver. Under these conditions there were increased concentrations of glutamic–aspartic and glutamic–alanine transaminases in the liver. With dietary depletion and repletion of protein the transaminase levels followed changes in liver size. Since the protein concentration in the liver was not affected, the level of transaminase was directly associated with the degree of anabolism. The changes in the glutamic–alanine transaminase were the more pronounced.

scholarly journals Diabetes Insipidus Accompanied with Acute Kidney Injury, which was Revealed by Acute Fatty Liver of Pregnancy.

2011 ◽  
Vol 100 (10) ◽  
pp. 3044-3047
Author(s):  
Hiroki Takimoto ◽  
Katsuyuki Nagatoya ◽  
Yoko Yamauchi ◽  
Hirohisa Matsuda ◽  
Tatsuhiko Mori ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Fatty Liver ◽  
Diabetes Insipidus ◽  
Kidney Injury ◽  
Acute Fatty Liver

Acute Fatty Liver

2018 ◽  
pp. 13-15
Author(s):  
Aiyuan Li ◽  
Weike Tao
Keyword(s):  
Fatty Liver ◽  
Acute Fatty Liver

Readiness, Recognition, Response, and Reporting in a Case of Acute Fatty Liver of Pregnancy

2018 ◽  
Vol 22 (6) ◽  
pp. 481-488
Author(s):  
Jane Ciaramella
Keyword(s):  
Fatty Liver ◽  
Recognition Response ◽  
Acute Fatty Liver

scholarly journals ACUTE FATTY LIVER OF PREGNANCY MASQUERADING AS HELLP SYNDROME

2018 ◽  
Vol 5 (20) ◽  
pp. 1592-1595
Author(s):  
Santhosh Narayanan ◽  
Divya Prakash ◽  
Gomathy Subramaniam ◽  
Lakshminarayanan Lakshminarayanan
Keyword(s):  
Fatty Liver ◽  
Hellp Syndrome ◽  
Acute Fatty Liver

scholarly journals Comparison of Maternal and Neonatal Outcomes between Acute Fatty Liver of Pregnancy and Hemolysis, Elevated Liver Enzymes and Low Platelets Syndrome: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Sau Xiong Ang ◽  
Chie-Pein Chen ◽  
Fang-Ju Sun ◽  
Chen-Yu Chen
Keyword(s):  
Cohort Study ◽  
Fatty Liver ◽  
Retrospective Cohort Study ◽  
Hellp Syndrome ◽  
Retrospective Cohort ◽  
Liver Enzymes ◽  
Neonatal Outcomes ◽  
Elevated Liver Enzymes ◽  
Acute Fatty Liver ◽  
Maternal And Neonatal Outcomes

Abstract Background: Acute fatty liver of pregnancy (AFLP) and hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome are two uncommon disorders that mimic each other clinically, but are distinct pathophysiologically. This study aimed to compare maternal and neonatal outcomes between AFLP and HELLP syndrome.Methods: This retrospective cohort study was performed at a tertiary referral center in Taiwan between June 2004 and April 2020. We used the Swansea Criteria to diagnose AFLP, and the Tennessee Classification System to diagnose HELLP syndrome. Maternal characteristics, laboratory data, complications, and neonatal outcomes were analyzed.Results: During the study period, 21 women had AFLP and 80 women had HELLP syndrome. There was a higher rate of preeclampsia (95.0% versus 23.8%) in the HELLP syndrome group compared to the AFLP group. However, the AFLP group had more other maternal complications including jaundice (85.7% versus 13.8%), acute kidney injury (61.9% versus 15.0%), disseminated intravascular coagulopathy (66.7% versus 8.8%), and sepsis (47.6% versus 10.0%) compared to the HELLP syndrome group. Nevertheless, higher rates of small for gestational age neonates (57.1% versus 33.3%), neonatal respiratory distress syndrome (39.2% versus 8.3%) and neonatal sepsis (34.2% versus 12.5%) were noted in the HELLP syndrome group.Conclusions: AFLP is associated with a higher rate of multiple organ dysfunction in mothers, whereas HELLP syndrome is associated with a higher rate of neonatal morbidity.

scholarly journals Sickle cell anaemia in vaso-occlusive crisis and acute fatty liver of pregnancy: a case report

2020 ◽  
Vol 54 (3) ◽  
pp. 201-203
Author(s):  
Michael Ezeanochie ◽  
Oghenefegor Olokor ◽  
Ofure Yamah
Keyword(s):  
Case Report ◽  
Fatty Liver ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Elevated Serum ◽  
Simultaneous Occurrence ◽  
Published Data ◽  
Care Providers ◽  
Delay In Diagnosis ◽  
Acute Fatty Liver

Acute fatty liver of pregnancy (AFLP) is an uncommon condition that manifests in the third trimester of pregnancy.Its association with vaso-occlusive crisis from Sickle Cell Anaemia is not common. Published data on the simultaneous occurrence of these two conditions is rare, hence this case report. A 32-year-old gravida 3 para 1+1 lady, with Sickle Cell Anaemia, had a vaso-occlusive crisis in association with AFLP at 32 weeks’ gestation, and the outcome of her management was successful. AFLP is a rare late-gestational event affecting about 1 in 10,000 to 15,000 pregnancies. The exact aetiology is not known. Profound hypoglycaemia and jaundice with elevated serum transaminases are recognized features of AFLP.These features may also be seen in haemoglobinopathies. The simultaneous occurrence of AFLP and Sickle Cell Anaemia may result in overlap of symptoms and delay in diagnosis and treatment. Therefore, maintaining a high index of suspicion is key. The cornerstone for treatment remains prompt delivery and supportive care. AFLP can coexist with Sickle cell crises. It is important that care providers, especially in populations with high burden of Sickle Cell Anaemia, consider this as a differential diagnosis, especially when the jaundice is associated with profound or recurring episodes of hypoglycaemia. Prompt diagnosis and delivery in a multidisciplinary approach is important to avoid adverse maternal and foetal outcomes.Keywords: Vaso-occlusive crises, acute fatty liver of pregnancy, hypoglycaemia, Sickle-cell anaemiaFunding: No funding sources

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