Use of paroxetine for the treatment of depression and anxiety disorders in the elderly: a review

2003 ◽  
Vol 18 (3) ◽  
pp. 185-190 ◽  
Author(s):  
Michel Bourin
Author(s):  
Daniela Felice ◽  
Anand Gururajan ◽  
Olivia F O’Leary ◽  
John F Cryan

Depression and anxiety disorders cause the greatest global disability in terms of impact on the individual, family, and society at large. The etiology of these disorders is multifactorial and includes complex interactions between genetic and environmental risk factors. This chapter reviews preclinical studies assessing the importance of gene–environment (G×E) interaction. Specifically, we focus on G×E studies assessing the roles of the hypothalamic–pituitary–adrenal (HPA) axis, serotonergic system, GABAergic system, and brain-derived neurotrophic factor (BDNF) system. Finally, novel candidate target genes for the treatment of depression and anxiety disorders are considered.


2018 ◽  
Vol 23 (9) ◽  
pp. 1136-1147 ◽  
Author(s):  
Michael J Scott

Improving Access to Psychological Therapies is a UK government-funded initiative to widen access to the psychological treatment of depression and anxiety disorders. The author has had the opportunity to independently assess 90 Improving Access to Psychological Therapies clients, using a standardised semi-structured interview, the Structured Clinical Diagnostic Interview for DSM Disorders (SCID) and to listen to their account of interaction with the service. The results suggest that only the tip of the iceberg fully recovers from their disorder (9.2%) whether or not they were treated before or after a personal injury claim. There is a pressing need to re-examine the modus operandi of the service.


2021 ◽  
Vol 14 (2) ◽  
pp. 158-161
Author(s):  
Bartosz Sapilak ◽  
Anna Antosik-Wójcińska

Depressive and anxiety disorders are nowadays the most common chronic psychiatric disorders, its diagnosis and treatment is the competence of family doctors. The family doctors have the best chance to find the symptoms of the disease, make decision to initiate the therapy, and, in difficult cases, refer the patient to a specialist. Depression is a systemic disease affecting life of the patient and his family, including the symptomatology of somatic diseases (pain syndromes, stenocardia, arrhythmias and gastric ailments). This disease should be treated at an early stage. It is a serious mistake both to ignore the symptoms and conservatively refer all patients for specialist consultation, without first attempting to start therapy. A large group of patients will simply not take advantage of this option and will be left without treatment.


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