Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers

2008 ◽  
Vol 123 (2) ◽  
pp. 457-463 ◽  
Author(s):  
Patrick Danoy ◽  
Stefan Michiels ◽  
Philippe Dessen ◽  
Cécile Pignat ◽  
Thomas Boulet ◽  
...  
Keyword(s):  
Dna Damage ◽  
Head And Neck ◽  
Dna Damage Response ◽  
Strand Break ◽  
Double Strand Break ◽  
Head And Neck Cancers ◽  
Double Strand Break Repair ◽  
Dna Double Strand Break ◽  
Damage Response ◽  
Break Repair

scholarly journals The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response

Oncogene ◽  
2012 ◽  
Vol 31 (45) ◽  
pp. 4803-4809 ◽  
Author(s):  
C Lemaître ◽  
B Fischer ◽  
A Kalousi ◽  
A-S Hoffbeck ◽  
J Guirouilh-Barbat ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Damage Response ◽  
Break Repair

scholarly journals MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair

2010 ◽  
Vol 30 (14) ◽  
pp. 3582-3595 ◽  
Author(s):  
Girdhar G. Sharma ◽  
Sairei So ◽  
Arun Gupta ◽  
Rakesh Kumar ◽  
Christelle Cayrou ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Histone H4 ◽  
Dsb Repair ◽  
Altered Expression ◽  
Damage Response ◽  
Break Repair

ABSTRACT The human MOF gene encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac). Here we show that reduced levels of H4K16ac correlate with a defective DNA damage response (DDR) and double-strand break (DSB) repair to ionizing radiation (IR). The defect, however, is not due to altered expression of proteins involved in DDR. Abrogation of IR-induced DDR by MOF depletion is inhibited by blocking H4K16ac deacetylation. MOF was found to be associated with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a protein involved in nonhomologous end-joining (NHEJ) repair. ATM-dependent IR-induced phosphorylation of DNA-PKcs was also abrogated in MOF-depleted cells. Our data indicate that MOF depletion greatly decreased DNA double-strand break repair by both NHEJ and homologous recombination (HR). In addition, MOF activity was associated with general chromatin upon DNA damage and colocalized with the synaptonemal complex in male meiocytes. We propose that MOF, through H4K16ac (histone code), has a critical role at multiple stages in the cellular DNA damage response and DSB repair.

scholarly journals Phenothiazine Inhibitors of TLKs Affect Double-Strand Break Repair and DNA Damage Response Recovery and Potentiate Tumor Killing with Radiomimetic Therapy

2013 ◽  
Vol 4 (1-2) ◽  
pp. 39-53 ◽  
Author(s):  
S. Ronald ◽  
S. Awate ◽  
A. Rath ◽  
J. Carroll ◽  
F. Galiano ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Response Recovery ◽  
Damage Response ◽  
Tumor Killing ◽  
Break Repair

scholarly journals The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Cell ◽  
1998 ◽  
Vol 93 (3) ◽  
pp. 477-486 ◽  
Author(s):  
James P Carney ◽  
Richard S Maser ◽  
Heidi Olivares ◽  
Elizabeth M Davis ◽  
Michelle Le Beau ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Protein Complex ◽  
Nijmegen Breakage Syndrome ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Damage Response ◽  
Break Repair ◽  
Cellular Dna

Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice

2016 ◽  
Vol 119 (2) ◽  
pp. 276-281 ◽  
Author(s):  
Ali Bakr ◽  
Sabrina Köcher ◽  
Jennifer Volquardsen ◽  
Rudolph Reimer ◽  
Kerstin Borgmann ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Damage Response ◽  
Break Repair

scholarly journals Schizosaccharomyces pombe KAT5 contributes to resection and repair of a DNA double strand break

Genetics ◽  
2021 ◽  
Author(s):  
Tingting Li ◽  
Ruben C Petreaca ◽  
Susan L Forsburg
Keyword(s):  
Dna Damage ◽  
Homologous Recombination ◽  
Chromatin Remodeling ◽  
Dna Damage Response ◽  
Histone Acetyltransferase ◽  
Strand Break ◽  
Double Strand Break ◽  
Dna Damage Checkpoint ◽  
Dna Double Strand Break ◽  
Damage Response

Abstract Chromatin remodeling is essential for effective repair of a DNA double strand break. KAT5 (S. pombe Mst1, human TIP60) is a MYST family histone acetyltransferase conserved from yeast to humans that coordinates various DNA damage response activities at a DNA double strand break (DSB), including histone remodeling and activation of the DNA damage checkpoint. In S. pombe, mutations in mst1+ causes sensitivity to DNA damaging drugs. Here we show that Mst1 is recruited to DSBs. Mutation of mst1+ disrupts recruitment of repair proteins and delays resection. These defects are partially rescued by deletion of pku70, which has been previously shown to antagonize repair by homologous recombination. These phenotypes of mst1 are similar to pht1-4KR, a non-acetylatable form of histone variant H2A.Z, which has been proposed to affect resection. Our data suggest that Mst1 functions to direct repair of DSBs towards homologous recombination pathways by modulating resection at the double strand break.

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