scholarly journals Inhibition of matrix metalloproteinase-2 enhances radiosensitivity by abrogating radiation-induced FoxM1-mediated G2/M arrest in A549 lung cancer cells

2009 ◽  
Vol 124 (10) ◽  
pp. 2468-2477 ◽  
Author(s):  
Chandramu Chetty ◽  
Praveen Bhoopathi ◽  
Jasti S. Rao ◽  
Sajani S. Lakka
Keyword(s):  
Lung Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Matrix Metalloproteinase 2 ◽  
Radiation Induced ◽  
A549 Lung

Inhibitory Effect of Poria cocos Polysaccharides on Proliferation, Migration, and Invasion of Lung Cancer Cells, A549

2021 ◽  
Vol 20 (1) ◽  
pp. 147-152
Author(s):  
Hongyan Jiang ◽  
Zhong Duanmu
Keyword(s):  
Lung Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Inhibitory Effect ◽  
Lung Cancer Cells ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Inhibition Of Proliferation ◽  
Poria Cocos

We have investigated the inhibitory effect of polysaccharides of Poria cocos on the proliferation, migration, and invasion of A549 lung cancer cells. The results showed that compared to the control group, the proliferation, migration, and invasion ability of all the treatment groups were inhibited, and the expression levels of ki-67 protein, matrix metalloproteinase-2, and matrix metalloproteinase-9 were also inhibited (P < 0.05). Moreover, polysaccharides of P. cocos significantly inhibited the expression of nuclear factor-kappa B (NF-κB) signaling pathway related genes p-p65 and p-IκB (P < 0.05). In conclusion, the mechanism of the inhibition of proliferation, migration, and invasion of lung cancer A549 cells by the polysaccharides of P. cocos may involve the inhibition of the NF-κB signaling pathway.

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