scholarly journals Novel point mutations and mutational complexes in the enhancer II, core promoter and precore regions of hepatitis B virus genotype D1 associated with hepatocellular carcinoma in Saudi Arabia

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Anis Khan ◽  
Mohammed A. Al Balwi ◽  
Yasuhito Tanaka ◽  
Ali Hajeer ◽  
Faisal M. Sanai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Saudi Arabia ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Point Mutations ◽  
Virus Genotype ◽  
B Virus ◽  
Enhancer Ii

Clinical features and prognosis of hepatocellular carcinoma with respect to pre-S deletion and basal core promoter mutations of hepatitis B virus Genotype C2

2011 ◽  
Vol 83 (12) ◽  
pp. 2088-2095 ◽  
Author(s):  
Han Jak Ryu ◽  
Do Young Kim ◽  
Jun Yong Park ◽  
Hye Young Chang ◽  
Myoung Ha Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Features ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Virus Genotype ◽  
B Virus ◽  
Promoter Mutations

scholarly journals Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels

Gut ◽  
2007 ◽  
Vol 57 (1) ◽  
pp. 98-102 ◽  
Author(s):  
M-F Yuen ◽  
Y Tanaka ◽  
N Shinkai ◽  
R T Poon ◽  
D Y.-K. But ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Hbv Dna ◽  
B Virus ◽  
Virus Genotypes ◽  
Enhancer Ii

Specific mutations in the enhancer II/core promoter/precore regions of hepatitis B virus subgenotype C2 in Korean patients with hepatocellular carcinoma

2009 ◽  
Vol 81 (6) ◽  
pp. 1002-1008 ◽  
Author(s):  
Ja Kyung Kim ◽  
Hye Young Chang ◽  
Jung Min Lee ◽  
Oidov Baatarkhuu ◽  
Young Joon Yoon ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Korean Patients ◽  
B Virus ◽  
Enhancer Ii

scholarly journals Sequence Analysis of PreS2 Region of Hepatitis B Virus Genotype D Isolates

2021 ◽  
Vol 3 (1) ◽  
pp. 5-11
Author(s):  
Amania Anwar ◽  
Sheeba Murad ◽  
Hajra Sadia
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Point Mutations ◽  
Cell Permeability ◽  
Serum Samples ◽  
Virus Genotype ◽  
Hbv Genotype ◽  
Hbv Genotypes ◽  
B Virus

Hepatitis B virus (HBV) is a well known agent of liver diseases. HBV disease burden varies across theglobe with regions from low to high endemicity. Pakistan lies in the intermediate endemic zone, withhigh rate of mortality due to liver disease, cirrhosis and hepatocellular carcinoma. There is a wide rangeof heterogeneity in relation to HBV genotypes and sub-genotypes and in their patterns of pathogenesis,virulence and response to antiviral therapy. A large number of HBV genomic variations are associatedwith clinical outcomes such as hepatocellular carcinoma and liver cirrhosis. Thus, the present study aimsto analyze PreS2 gene sequences from HBV isolates and their phylogeny. To investigate this, a study wasconducted on twenty one HBV chronically infected individuals, serum samples were subjected to PCRwith specific primers for PreS2 region of HBV genotype D and then sequenced. Point mutations: A39V,P41H and L42I were found in cell permeability domain of PreS2 protein. However, MHC class I and IIepitopes were conserved in all sequences. Phylogenetic analysis was carried out by comparing thenucleotide sequence with 22 reference sequences of HBV sub-genotype D retrieved from the GeneBank.Phylogenetic analysis showed that two of our isolates, ASAB1 (2266) and ASAB3 (PIMS 7) sharedcluster 1 with China D1, Pakistan D1, Iran D1 and Turkey D1. Meanwhile, ASAB2 (HF2) was grouped incluster 2 with Lebanese D2 and Brazil D2.

scholarly journals A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular carcinoma patients in Taiwan

2009 ◽  
Vol 125 (3) ◽  
pp. 621-629 ◽  
Author(s):  
Chien-Hung Chen ◽  
Chi-Sin Changchien ◽  
Chuan-Mo Lee ◽  
Wei-Chih Tung ◽  
Chao-Hung Hung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Occult Hepatitis ◽  
Sequence Variations ◽  
B Virus ◽  
Occult Hepatitis B ◽  
Enhancer Ii

Effect of combined mutations in the enhancer II and basal core promoter of hepatitis B virus on development of hepatocellular carcinoma in Qidong, China

2014 ◽  
Vol 44 (12) ◽  
pp. 1186-1195 ◽  
Author(s):  
Li-Shuai Qu ◽  
Jing Zhu ◽  
Tao-Tao Liu ◽  
Xi-Zhong Shen ◽  
Tao-Yang Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
B Virus ◽  
Enhancer Ii

scholarly journals Erratum: Clinical features and prognosis of hepatocellular carcinoma with respect to pre-S deletion and basal core promoter mutations of hepatitis B virus Genotype C2

2011 ◽  
Vol 84 (1) ◽  
pp. 182-182
Author(s):  
Han Jak Ryu ◽  
Do Young Kim ◽  
Jun Yong Park ◽  
Hye Young Chang ◽  
Myoung Ha Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Features ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Virus Genotype ◽  
B Virus ◽  
Promoter Mutations

scholarly journals Hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma

2011 ◽  
Vol 2 (3) ◽  
pp. 129
Author(s):  
Camillo Porta
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
National Cancer Institute ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Common Variants ◽  
Virus Genotype ◽  
Hbv Genotypes ◽  
B Virus

In the August issue of the authoritative Journal of the National Cancer Institute, a research group from Taiwan reported the results of a huge study aimed at assessing a possible association between Hepatitis B virus (HBV) genotypes and common variants in the precore and basal core promoter (BP) regions and the risk of hepatocellular carcinoma (HCC)...

Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma

2006 ◽  
Vol 45 (5) ◽  
pp. 646-653 ◽  
Author(s):  
Yasuhito Tanaka ◽  
Motokazu Mukaide ◽  
Etsuro Orito ◽  
Man-Fung Yuen ◽  
Kiyoaki Ito ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
B Virus ◽  
Enhancer Ii

scholarly journals A case–control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma

2010 ◽  
Vol 4 (3) ◽  
pp. 577-584 ◽  
Author(s):  
Pisit Tangkijvanich ◽  
Pattaratida Sa-nguanmoo ◽  
Varocha Mahachai ◽  
Apiradee Theamboonlers ◽  
Yong Poovorawan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Core Promoter ◽  
Case Control ◽  
Sequence Variations ◽  
B Virus ◽  
Enhancer Ii ◽  
Control Study
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