scholarly journals Hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma

2011 ◽  
Vol 2 (3) ◽  
pp. 129
Author(s):  
Camillo Porta
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
National Cancer Institute ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Common Variants ◽  
Virus Genotype ◽  
Hbv Genotypes ◽  
B Virus

In the August issue of the authoritative Journal of the National Cancer Institute, a research group from Taiwan reported the results of a huge study aimed at assessing a possible association between Hepatitis B virus (HBV) genotypes and common variants in the precore and basal core promoter (BP) regions and the risk of hepatocellular carcinoma (HCC)...

Precore and basal core promoter hepatitis B virus (HBV) variants are present from a young age and differ across HBV genotypes

Hepatology ◽  
2020 ◽  
Author(s):  
Daryl T.Y. Lau ◽  
Lilia Ganova‐Raeva ◽  
Junyao Wang ◽  
Douglas Mogul ◽  
Raymond T. Chung ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Young Age ◽  
Basal Core Promoter ◽  
Hbv Genotypes ◽  
B Virus ◽  
Hbv Variants

Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers

2003 ◽  
Vol 124 (2) ◽  
pp. 327-334 ◽  
Author(s):  
Jia–Horng Kao ◽  
Pei–Jer Chen ◽  
Ming–Yang Lai ◽  
Ding–Shinn Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
B Virus ◽  
Promoter Mutations

scholarly journals Genotyping Hepatitis B virus from whole- and sub-genomic fragments using position-specific scoring matrices in hbv star

2006 ◽  
Vol 87 (6) ◽  
pp. 1459-1464 ◽  
Author(s):  
Richard Myers ◽  
Caroline Clark ◽  
Arshad Khan ◽  
Paul Kellam ◽  
Richard Tedder
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Full Length ◽  
Basal Core Promoter ◽  
Hbv Genotype ◽  
Promoter Sequences ◽  
Hbv Genotypes ◽  
Scoring Matrices ◽  
B Virus

Hepatitis B virus (HBV) genomes have been classified into eight genotypes based on phylogenetic analysis of sequence variation. Identifying and tracking the movement of HBV genotypes is important in terms of both monitoring infection rates and predicting disease and treatment. An HBV genotyping tool has been developed that compares query sequences with position-specific scoring matrices representing the eight HBV genotypes. This tool (hbv star) is rapid, robust and accurate and assigns genotype based on a statistically defined scoring model. hbv star confidently assigned 90 % of 590 full-length HBV genomes to an HBV genotype (Z score >2.0). Thirty-two of the residual 48 sequences were identified as non-human primate viruses and 16 sequences were identified as recombinant or putative recombinants. Receiver-Operated Characteristic (ROC) analysis was used to compare the accuracy of genotype prediction using basal core promoter sequences and surface and core genes with the accuracy achieved by using full-length sequences. A web interface to hbv star is available at http://www.vgb.ucl.ac.uk/starn.shtml.

Characterization of Basal Core Promoter/Precore Gene Mutations in Chronically Infected Patients with Hepatitis B Virus Genotype D in Mersin Province, Turkey

2015 ◽  
Vol 49 (3) ◽  
pp. 377-392
Author(s):  
Seda TEZCAN ◽  
Mahmut ÜLGER ◽  
Enver ÜÇBİLEK ◽  
Gönül ASLAN ◽  
Mehmet Sami SERİN ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Gene Mutations ◽  
Basal Core Promoter ◽  
Virus Genotype ◽  
B Virus

scholarly journals Sequence Analysis of PreS2 Region of Hepatitis B Virus Genotype D Isolates

2021 ◽  
Vol 3 (1) ◽  
pp. 5-11
Author(s):  
Amania Anwar ◽  
Sheeba Murad ◽  
Hajra Sadia
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Point Mutations ◽  
Cell Permeability ◽  
Serum Samples ◽  
Virus Genotype ◽  
Hbv Genotype ◽  
Hbv Genotypes ◽  
B Virus

Hepatitis B virus (HBV) is a well known agent of liver diseases. HBV disease burden varies across theglobe with regions from low to high endemicity. Pakistan lies in the intermediate endemic zone, withhigh rate of mortality due to liver disease, cirrhosis and hepatocellular carcinoma. There is a wide rangeof heterogeneity in relation to HBV genotypes and sub-genotypes and in their patterns of pathogenesis,virulence and response to antiviral therapy. A large number of HBV genomic variations are associatedwith clinical outcomes such as hepatocellular carcinoma and liver cirrhosis. Thus, the present study aimsto analyze PreS2 gene sequences from HBV isolates and their phylogeny. To investigate this, a study wasconducted on twenty one HBV chronically infected individuals, serum samples were subjected to PCRwith specific primers for PreS2 region of HBV genotype D and then sequenced. Point mutations: A39V,P41H and L42I were found in cell permeability domain of PreS2 protein. However, MHC class I and IIepitopes were conserved in all sequences. Phylogenetic analysis was carried out by comparing thenucleotide sequence with 22 reference sequences of HBV sub-genotype D retrieved from the GeneBank.Phylogenetic analysis showed that two of our isolates, ASAB1 (2266) and ASAB3 (PIMS 7) sharedcluster 1 with China D1, Pakistan D1, Iran D1 and Turkey D1. Meanwhile, ASAB2 (HF2) was grouped incluster 2 with Lebanese D2 and Brazil D2.

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