The von Hippel-Lindau (VHL) disease tumor-suppressor gene is not mutated in nasopharyngeal carcinomas

1995 ◽  
Vol 61 (3) ◽  
pp. 437-438 ◽  
Author(s):  
Yi Sun ◽  
Allan Hildesheim ◽  
Hua Li ◽  
Anne P. Lanier ◽  
Ya Cao ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Von Hippel Lindau ◽  
Vhl Disease ◽  
Disease Tumor Suppressor Gene

Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene

1998 ◽  
Vol 12 (6) ◽  
pp. 417-423 ◽  
Author(s):  
Catherine Stolle ◽  
Gladys Glenn ◽  
Berton Zbar ◽  
Jeffrey S. Humphrey ◽  
Peter Choyke ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Germline Mutations ◽  
Suppressor Gene ◽  
Von Hippel Lindau ◽  
Von Hippel Lindau Disease ◽  
Disease Tumor Suppressor Gene

Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: Correlations with phenotype

1995 ◽  
Vol 5 (1) ◽  
pp. 66-75 ◽  
Author(s):  
Fan Chen ◽  
Takeshi Kishida ◽  
Masahiro Yao ◽  
Thomas Hustad ◽  
Damjan Glavac ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Germline Mutations ◽  
Suppressor Gene ◽  
Von Hippel Lindau ◽  
Von Hippel Lindau Disease ◽  
Disease Tumor Suppressor Gene

Identification of the von Hippel-Lindau disease tumor suppressor gene

Science ◽  
1993 ◽  
Vol 260 (5112) ◽  
pp. 1317-1320 ◽  
Author(s):  
F Latif ◽  
K Tory ◽  
J Gnarra ◽  
M Yao ◽  
F. Duh ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Von Hippel Lindau ◽  
Von Hippel Lindau Disease ◽  
Disease Tumor Suppressor Gene

The von-Hippel-Lindau (VHL) tumor suppressor gene is not mutated in sporadic ovarian carcinomas

1996 ◽  
Author(s):  
R Nakashima ◽  
T Enomoto ◽  
M Fujita ◽  
K Yoshino ◽  
H Wada ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Ovarian Carcinomas ◽  
Von Hippel Lindau

scholarly journals VHL tumor suppressor regulates Cl−/HCO3− exchange and Na+/H+ exchange activities in renal carcinoma cells

2001 ◽  
Vol 5 (3) ◽  
pp. 119-128 ◽  
Author(s):  
S. ANANTH KARUMANCHI ◽  
LIANWEI JIANG ◽  
BERTRAND KNEBELMANN ◽  
ALAN K. STUART-TILLEY ◽  
SETH L. ALPER ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Mrna Level ◽  
Critical Role ◽  
Suppressor Gene ◽  
Mrna Levels ◽  
Differential Display Pcr ◽  
Von Hippel Lindau ◽  
Acid Load ◽  
Vhl Disease ◽  
Exchange Activity

Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene are thought to play a critical role in the pathogenesis of both sporadic and VHL disease-associated clear-cell renal carcinomas (RCC). Differential display-PCR identified the AE2 anion exchanger as a candidate VHL target gene. AE2 mRNA and polypeptide levels were approximately threefold higher in 786-O VHL cells than in 786-O Neo cells. In contrast, Cl−/HCO3− exchange activity in 786-O VHL cells was 50% lower than in 786-O Neo cells. Since resting intracellular pH (pHi) values were indistinguishable, we postulated that Na+/H+ exchange activity (NHE) might be similarly reduced in 786-O VHL cells. NHE-mediated pHi recovery from acid load was less than 50% that in 786-O Neo cells, whereas hypertonicity-stimulated, amiloride-sensitive NHE was indistinguishable in the two cell lines. The NHE3 mRNA level was higher in 786-O VHL than 786-O Neo cells, but NHE1 mRNA levels did not differ. AE2 and NHE3 are the first transcripts reported to be upregulated by pVHL. Elucidation of mechanisms responsible for downregulation of both ion exchange activities will require further investigation.

Targeting the Loss of the von Hippel-Lindau Tumor Suppressor Gene in Renal Cell Carcinoma Cells

2007 ◽  
Vol 67 (12) ◽  
pp. 5896-5905 ◽  
Author(s):  
Patrick D. Sutphin ◽  
Denise A. Chan ◽  
James M. Li ◽  
Sandra Turcotte ◽  
Adam J. Krieg ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Tumor Suppressor Gene ◽  
Renal Cell ◽  
Suppressor Gene ◽  
Carcinoma Cells ◽  
Von Hippel Lindau
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