Fertility preservation and survival among young women with early ovarian cancer living in US counties with gynecologic oncologist services

AbstractFertility preservation is an important option to consider for young women with low-grade early ovarian cancer. Fertility-sparing surgery (“FSS”) permits the conservation of the uterus and one of the ovaries. This technique is considered safe for stages IA G1, G2 and probably safe for IC G1 epithelial and non-epithelial ovarian cancers. There are still uncertainties and FSS is not fully accepted for stage IC G1, G2 and clear cell carcinoma. The difficulty in choosing the best option lies in the fact that there is a lack of prospective randomized studies, due to ethical and organizational issues. Retrospective studies and reviews showed reassuring results for FSS in terms of relapse and long term survival. The spontaneous pregnancy rate seems to decrease after FSS, but chemotherapy does not seem to have an impact on fertility rates. Compared with the general population, assisted reproductive techniques are considered safe and with similar fertility results.

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FERTILITY PRESERVATION WITH IN VIVO OOCYTE RETRIEVAL AMONG YOUNG WOMEN WITH OVARIAN CANCER: A CASE SERIES

Fertility and Sterility ◽

10.1016/j.fertnstert.2020.10.024 ◽

2020 ◽

Vol 114 (3) ◽

pp. e257

Author(s):

Alex Robles ◽

Brittany Noel Robles ◽

Laura C. Gemmell ◽

Paula C. Brady

Keyword(s):

Ovarian Cancer ◽

Fertility Preservation ◽

Young Women ◽

Case Series ◽

Oocyte Retrieval

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Fertility preservation in young women with epithelial ovarian cancer

Cancer ◽

10.1002/cncr.24461 ◽

2009 ◽

Vol 115 (18) ◽

pp. 4118-4126 ◽

Cited By ~ 88

Author(s):

Jason D. Wright ◽

Monjri Shah ◽

Leny Mathew ◽

William M. Burke ◽

Jennifer Culhane ◽

...

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Fertility Preservation ◽

Young Women

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Update on fertility preservation in young women undergoing breast cancer and ovarian cancer therapy

Current Opinion in Obstetrics & Gynecology ◽

10.1097/gco.0000000000000138 ◽

2015 ◽

Vol 27 (1) ◽

pp. 98-107 ◽

Cited By ~ 31

Author(s):

Matteo Lambertini ◽

Elizabeth S. Ginsburg ◽

Ann H. Partridge

Keyword(s):

Breast Cancer ◽

Ovarian Cancer ◽

Cancer Therapy ◽

Fertility Preservation ◽

Young Women

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Fertility preservation option in young women with ovarian cancer

Future Oncology ◽

10.2217/fon-2016-0181 ◽

2016 ◽

Vol 12 (14) ◽

pp. 1695-1698 ◽

Cited By ~ 5

Author(s):

So-Youn Kim ◽

Jung Ryeol Lee

Keyword(s):

Ovarian Cancer ◽

Fertility Preservation ◽

Young Women

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Clinico-pathological characterstics of epithelial ovarian malignancy in young female

10.1055/s-0039-1685298 ◽

2016 ◽

Author(s):

Dhananjay Ghuge ◽

Alok Tiwari ◽

Subraharsh Singh ◽

Satinder Kaur

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Fertility Preservation ◽

Young Women ◽

Maximum Diameter ◽

Ca 125 ◽

Serous Adenocarcinoma ◽

Average Maximum ◽

The Common ◽

Well Differentiated

Background and Objective: Epithelial ovarian cancer mostly appears in aged women, but rarely in young women. Little is known about the clinical characteristics and prognosis of epithelial ovarian cancer in women aged below 40 years. This study was to evaluate the clinical and histopathological characteristics of young patients with epithelial ovarian cancer. Methods: A total of 31 patients with confirmed epithelial ovarian cancer under the age of 40 years between 2007 to 2015 were retrospectively analyzed. Results: Mean age of the patient is 32 years. The common symptoms included abdominal pain (21 patient 67%), self detected pelvic mass (9 patient 29%) and 1 patient with bleeding per vaginum. The average maximum diameter of tumour is 10.7 cm. Family history positive in 8 patient (5 ca.breast and 3 ca.ovary). Mean level of CA. 125 is 883.36 u/ml. CA 125 level lowest is of 6 u/ml and highest is of 7557 u/ml. Tumour located bilaterally in 14 patient (45%). Ascitis present in 18 patient (58%). Pleural effusion seen in 6 patient (19%). Twenty six cases underwent optimal cytoreduction out of them 7 taken NACT. Two patient underwent fertility preservation surgery. Three patient underwent palliative chemotherapy due to unwillingness. Eleven patient classified as stage III and stage IV each (35% of each), six patient is of stage I (19%) and three patient of stage II (9.6%). Serous adenocarcinoma (80.6%) and mucinous adenocarcinoma (19%) are the common histopathological findings. Thirteen patient (41.9%) has well differentiated tumour, eight (25.8%) has moderately differentiated and ten (32.25%) has poorely differentiated tumour. Twenty eight patient received platinum and paclitaxel-based chemotherapy before or after operation. Conclusion: Young women with epithelial ovarian cancer under the age of 40 years mostly have serous adenocarcinoma; well differentiated and tumors are normally bilateral. The ovarian function can be preserved (fertility preservation) in part of stage Ia and Grade I patients.

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Fertility preservation surgeries and reproductive technologies in patients with early ovarian cancer and borderline tumors

Problems in oncology ◽

10.37469/0507-3758-2021-67-4-547-553 ◽

2021 ◽

Vol 67 (4) ◽

pp. 547-553

Author(s):

Olga Lavrinovich ◽

Mariia Iakovleva ◽

Igor Berlev ◽

Adel Urmancheeva

Keyword(s):

Ovarian Cancer ◽

Fertility Preservation ◽

Scientific Community ◽

High Efficiency ◽

Reproductive Technologies ◽

Reliable Data ◽

International Scientific Community ◽

Borderline Tumors ◽

Oncological Safety ◽

Early Ovarian Cancer

Currently, available data indicate the oncological safety and high efficiency of fertility preservation surgeries and reproductive technologies in patients with early ovarian cancer. The international scientific community is increasingly discussing the importance of timely patient information and the implementation of fertility preservation strategies in patients with early ovarian cancer. Research in this area should be continued due to the lack of reliable data.

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