Faculty Opinions recommendation of Fertility preservation in young women with epithelial ovarian cancer.

2009 ◽  
Author(s):  
Philippe Van Trappen
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fertility Preservation ◽  
Young Women

Fertility preservation in young women with epithelial ovarian cancer

Cancer ◽  
2009 ◽  
Vol 115 (18) ◽  
pp. 4118-4126 ◽  
Author(s):  
Jason D. Wright ◽  
Monjri Shah ◽  
Leny Mathew ◽  
William M. Burke ◽  
Jennifer Culhane ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fertility Preservation ◽  
Young Women

scholarly journals Clinico-pathological characterstics of epithelial ovarian malignancy in young female

2016 ◽  
Author(s):  
Dhananjay Ghuge ◽  
Alok Tiwari ◽  
Subraharsh Singh ◽  
Satinder Kaur
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fertility Preservation ◽  
Young Women ◽  
Maximum Diameter ◽  
Ca 125 ◽  
Serous Adenocarcinoma ◽  
Average Maximum ◽  
The Common ◽  
Well Differentiated

Background and Objective: Epithelial ovarian cancer mostly appears in aged women, but rarely in young women. Little is known about the clinical characteristics and prognosis of epithelial ovarian cancer in women aged below 40 years. This study was to evaluate the clinical and histopathological characteristics of young patients with epithelial ovarian cancer. Methods: A total of 31 patients with confirmed epithelial ovarian cancer under the age of 40 years between 2007 to 2015 were retrospectively analyzed. Results: Mean age of the patient is 32 years. The common symptoms included abdominal pain (21 patient 67%), self detected pelvic mass (9 patient 29%) and 1 patient with bleeding per vaginum. The average maximum diameter of tumour is 10.7 cm. Family history positive in 8 patient (5 ca.breast and 3 ca.ovary). Mean level of CA. 125 is 883.36 u/ml. CA 125 level lowest is of 6 u/ml and highest is of 7557 u/ml. Tumour located bilaterally in 14 patient (45%). Ascitis present in 18 patient (58%). Pleural effusion seen in 6 patient (19%). Twenty six cases underwent optimal cytoreduction out of them 7 taken NACT. Two patient underwent fertility preservation surgery. Three patient underwent palliative chemotherapy due to unwillingness. Eleven patient classified as stage III and stage IV each (35% of each), six patient is of stage I (19%) and three patient of stage II (9.6%). Serous adenocarcinoma (80.6%) and mucinous adenocarcinoma (19%) are the common histopathological findings. Thirteen patient (41.9%) has well differentiated tumour, eight (25.8%) has moderately differentiated and ten (32.25%) has poorely differentiated tumour. Twenty eight patient received platinum and paclitaxel-based chemotherapy before or after operation. Conclusion: Young women with epithelial ovarian cancer under the age of 40 years mostly have serous adenocarcinoma; well differentiated and tumors are normally bilateral. The ovarian function can be preserved (fertility preservation) in part of stage Ia and Grade I patients.

scholarly journals FERTILITY PRESERVATION WITH IN VIVO OOCYTE RETRIEVAL AMONG YOUNG WOMEN WITH OVARIAN CANCER: A CASE SERIES

2020 ◽  
Vol 114 (3) ◽  
pp. e257
Author(s):  
Alex Robles ◽  
Brittany Noel Robles ◽  
Laura C. Gemmell ◽  
Paula C. Brady
Keyword(s):  
Ovarian Cancer ◽  
Fertility Preservation ◽  
Young Women ◽  
Case Series ◽  
Oocyte Retrieval

scholarly journals Fertility preservation in patients with early epithelial ovarian cancer

2009 ◽  
Vol 20 (1) ◽  
pp. 44 ◽  
Author(s):  
Yong-Soon Kwon ◽  
Ho-Suap Hahn ◽  
Tae-Jin Kim ◽  
In-Ho Lee ◽  
Kyung-Taek Lim ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fertility Preservation

scholarly journals A Swedish Nationwide prospective study of oncological and reproductive outcome following fertility-sparing surgery for treatment of early stage epithelial ovarian cancer in young women

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Gry Johansen ◽  
Pernilla Dahm-Kähler ◽  
Christian Staf ◽  
Angelique Flöter Rådestad ◽  
Kenny A. Rodriguez-Wallberg
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Young Women ◽  
Gynecological Cancer ◽  
Population Based ◽  
Prognostic Impact ◽  
Fertility Sparing Surgery ◽  
Quality Register ◽  
Fertility Sparing ◽  
Histologic Subtypes

Abstract Background Epithelial ovarian cancer (EOC) is rare in women of reproductive age and fertility-sparing surgery (FSS) may be applied in early stages. The purpose of this study was to investigate the safety and efficacy of FSS for treatment of EOC. Methods The Swedish nationwide population-based Quality Register for Gynecological Cancer was used to identify all women 18–40 years of age diagnosed with stage I EOC between 2008 and 2015. Detailed data on surgery, staging, histopathology, and follow-up were extracted and reviewed. Cross-linking of individuals to population-based registries allowed retrieval of data on obstetrical and reproductive outcomes after FSS. Disease-free survival (DFS) and overall survival (OS) rates were compared (Kaplan-Meier method) between women who underwent FSS vs. radical surgery (RS). Results In total 83 women were identified; 36 who had FSS performed and 47 RS. The 5-year OS rate was 92% and no statistical differences between DFS or OS were found between women treated by FSS or RS. The recurrence rate after RS was 13% compared to 6% after FSS. Recurrences were more frequently found in women with stage IC tumor or with histologic subtypes with more aggressive behavior. In the FSS cohort, nine women gave birth to 12 healthy children, all delivered at fullterm. Only one women had received assisted reproductive technology treatment. Conclusion In this nationwide population-based cohort study natural fertility was maintained after FSS. Specific histologic subtypes showed greater prognostic impact on the oncological outcome than the use of FSS. Recurrences occurred after FSS, but none in the uterus, which questions the need of hysterectomy in young women with EOC. Trial registration This article reports the results of a healthcare intervention using the data prospectively registered in the Swedish population-based registries including the Quality Register for Gynecological Cancer, the National Death Register, the Swedish Medical Birth Register, and the National Quality Register for Assisted Reproduction.

scholarly journals Fertility preservation option in young women with ovarian cancer

2016 ◽  
Vol 12 (14) ◽  
pp. 1695-1698 ◽  
Author(s):  
So-Youn Kim ◽  
Jung Ryeol Lee
Keyword(s):  
Ovarian Cancer ◽  
Fertility Preservation ◽  
Young Women

scholarly journals The value of fertility-sparing surgery for young females with epithelial ovarian cancer: a comparative study

2021 ◽  
Vol 19 (1) ◽  
pp. e16-e21
Author(s):  
Waleed M. Etman ◽  
◽  
Mohamed Fathy Abohashim ◽  
Ramadan M. Ali ◽  
Osama Abd-Elaziz ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fertility Preservation ◽  
Radical Surgery ◽  
Survival Rates ◽  
Stage I ◽  
Young Females ◽  
Fertility Sparing Surgery ◽  
Surgery Group ◽  
Fertility Sparing

Background: Epithelial ovarian cancer is increasingly often diagnosed in young females who wish to preserve their fertility. Fertilitypreserving surgeries, where conservation of the uterus and contralateral ovary was performed, might be beneficial for patients with stage I epithelial ovarian cancer, but their safety is still controversial. In the present study, we aimed to compare radical surgery and fertility-saving surgery in females with stage IA–C epithelial ovarian cancer for recurrence and survival rates, as well as to evaluate reproductive and obstetric outcomes for stage I epithelial ovarian cancer females who were managed with fertility-saving surgery. Materials and methods: We prospectively identified 60 patients aged ≤40 years who were diagnosed with stage I epithelial ovarian cancer. The patients in the fertility-preservation group underwent salpingo-oophorectomy on the side of the affected ovary in addition to incisional biopsy or wedge excision of the ovary on the other side. The patients in the radical surgery group underwent total hysterectomy and bilateral salpingo-oophorectomy. We followed up all patients for 5 years to assess their reproductive and oncological outcomes. Results: Patients in the fertility preservation surgery group were significantly younger (30 ± 4 versus 35 ± 5 years) (p < 0.001), their tumor sizes were smaller (3.4 ± 1.3 versus 6.0 ± 2.6 cm) (p < 0.001), of lower grade (p = 0.011), earlier stage (p < 0.001) and had more mucinous histology than patients in the radical surgery group. There were no statistically significant differences between both groups regarding tumor recurrence or survival rates. Of 25 patients who underwent fertility preservation surgery, 18 (72%) attempted to conceive. A total of 15/18 (83%) pregnancies were recorded, including 13 live births, 1 miscarriage, and 1 intrauterine fetal death. Conclusion: Fertility-sparing surgery could be an adequate alternative to radical surgery for young females with stage I epithelial ovarian cancer.

Sign in / Sign up

Export Citation Format

Share Document